2024
External Disruption of Ocular Development in Utero
Kim H, Sarrafpour S, Teng C, Liu J. External Disruption of Ocular Development in Utero. The Yale Journal Of Biology And Medicine 2024, 97: 41-48. PMID: 38559457, PMCID: PMC10964818, DOI: 10.59249/rrmm8911.Peer-Reviewed Original ResearchConceptsOcular developmentOcular embryologyEnglish-language articlesIntrauterine infectionMaternal nutritionClinical significanceGenetic signaling pathwaysWeb of ScienceAnimal modelsHormonal factorsHuman studiesMultifactorial naturePregnancySignaling pathwayGoogle ScholarReviewIntrauterineEmbryologyLimited resourcesGestationUteroPathophysiologyFactorsInfectionPubMed
2020
Herbal Medicines in Glaucoma Treatment.
Ige M, Liu J. Herbal Medicines in Glaucoma Treatment. The Yale Journal Of Biology And Medicine 2020, 93: 347-353. PMID: 32607093, PMCID: PMC7309662.Peer-Reviewed Original ResearchConceptsCourse of glaucomaIntraocular pressureGlaucoma patientsGlaucoma treatmentRetinal ganglion cell deathHerbal medicineMedical marijuanaGanglion cell deathStandard therapeutic agentsSignificant adverse effectsCurrent standardGinkgo bilobaSurgical therapyGlaucoma managementIrreversible blindnessGlaucomaAlternative medicineLarger studyHerbal remediesTherapeutic agentsAddictive potentialAdverse effectsLonger durationPatientsShort duration
2018
Educational and Scholarly Opportunities for Medical Students and Residents in Professional Ophthalmology Organizations.
Yang A, Zhang X, Liu J, Chow J, Adelman R, Forster S. Educational and Scholarly Opportunities for Medical Students and Residents in Professional Ophthalmology Organizations. JAMA Ophthalmology 2018, 136: 1417-1419. PMID: 30326048, PMCID: PMC6594420, DOI: 10.1001/jamaophthalmol.2018.3963.Peer-Reviewed Original ResearchDelayed cystoid macular oedema after uncomplicated laser peripheral iridotomy
Yang AY, Kempton J, Liu J. Delayed cystoid macular oedema after uncomplicated laser peripheral iridotomy. Clinical And Experimental Ophthalmology 2018, 46: 823-824. PMID: 29468783, DOI: 10.1111/ceo.13180.Peer-Reviewed Original ResearchSequential cataract surgeries in a patient with a left ventricular assist device (LVAD)
Yang A, Liu J. Sequential cataract surgeries in a patient with a left ventricular assist device (LVAD). BMJ Case Reports 2018, 2018: bcr-2018-224238. PMID: 29549136, PMCID: PMC5878276, DOI: 10.1136/bcr-2018-224238.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceSequential cataract surgeryVentricular assist deviceQuality of lifeCataract surgeryElective surgeryAssist deviceNon-cardiac elective surgeryPopulation of patientsCardiology evaluationDisease courseHeart failureIntravenous sedationLVAD supportVisual acuityIntraoperative monitoringPoor visionCommon causeHigh riskPatientsSurgeryLVAD deviceSignificant improvementPotential benefitsSedation
2017
Irreversible Blindness Following Periocular Autologous Platelet-Rich Plasma Skin Rejuvenation Treatment
Kalyam K, Kavoussi SC, Ehrlich M, Teng CC, Chadha N, Khodadadeh S, Liu J. Irreversible Blindness Following Periocular Autologous Platelet-Rich Plasma Skin Rejuvenation Treatment. Ophthalmic Plastic And Reconstructive Surgery 2017, 33: s12-s16. PMID: 27015236, DOI: 10.1097/iop.0000000000000680.Peer-Reviewed Original ResearchConceptsAutologous platelet-rich plasma therapyPlatelet-rich plasma injectionPlatelet-rich plasma therapyOptic nerve infarctionAcute visual lossOccipital lobe infarctionOphthalmic artery occlusionNerve infarctionFundus examArtery occlusionExtensive ischemiaSkin necrosisSkin rejuvenation treatmentVascular etiologyVisual lossMuscle ischemiaOcular motilityRight eyePlasma therapyIrreversible blindnessGlabellar regionIschemiaInfarctionFirst casePlasma injectionNovel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma.
Lu LJ, Tsai JC, Liu J. Novel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma. The Yale Journal Of Biology And Medicine 2017, 90: 111-118. PMID: 28356898, PMCID: PMC5369028.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaOpen-angle glaucomaIntraocular pressureProstaglandin analoguesDrug-related side effectsCurrent medical treatment optionsLowering of IOPTarget intraocular pressureMedical treatment optionsVisual field lossAlpha-adrenergic agonistsNew pharmacologic optionsLower intraocular pressureMultiple daily administrationBeta-adrenergic antagonistsAdenosine receptor agonistsLow patient complianceAqueous humor outflowRho-kinase inhibitorTrabecular meshwork outflow pathwaysLatanoprostene bunodPharmacologic optionsPharmacologic treatmentTopical medicationsDaily administrationNovel therapeutics for Stargardt disease
Lu LJ, Liu J, Adelman RA. Novel therapeutics for Stargardt disease. Graefe's Archive For Clinical And Experimental Ophthalmology 2017, 255: 1057-1062. PMID: 28285324, DOI: 10.1007/s00417-017-3619-8.Peer-Reviewed Original ResearchConceptsStargardt diseaseVision lossABCA4 geneStem cell transplantationSevere vision lossPromising treatment candidateNovel therapeutic strategiesRetinal pigment epitheliumStem cell therapyVisual acuityStandard treatmentMacular degenerationTreatment candidatesHESC-RPE cellsStargardt patientsTherapeutic strategiesPharmacological agentsPigment epitheliumMacular dystrophyNovel therapeuticsPatientsDiseaseVisual cyclePrevalent formSecond decadeEpigenetics and Signaling Pathways in Glaucoma
Gauthier AC, Liu J. Epigenetics and Signaling Pathways in Glaucoma. BioMed Research International 2017, 2017: 5712341. PMID: 28210622, PMCID: PMC5292191, DOI: 10.1155/2017/5712341.Peer-Reviewed Original ResearchConceptsPotential new therapeutic targetGeneration of fibrosisNovel therapeutic agentsNew therapeutic targetsAqueous humor drainageProapoptotic gene expressionRetinal neuronsIrreversible blindnessCommon causeHuman trialsTherapeutic targetAnimal modelsTrabecular meshworkTherapeutic agentsNeurodegenerative diseasesProsurvival factorBcl-2Rho-kinaseGlaucomaSignaling pathwaysPathway membersMAP kinaseGene expressionPathwayPreliminary success
2016
Effect of supine body position on central corneal thickness
Maslin JS, Teng CC, Chadha N, Liu J. Effect of supine body position on central corneal thickness. Clinical And Experimental Ophthalmology 2016, 44: 678-683. PMID: 26991869, DOI: 10.1111/ceo.12742.Peer-Reviewed Original ResearchConceptsCentral corneal thicknessOpen-angle glaucoma patientsSupine body positionHealthy subjectsGlaucoma patientsSupine positioningMin supineCorneal thicknessBody positionLaterality of eyeAngle glaucoma patientsUniversity Eye ClinicCross-sectional studyGlaucoma groupEye clinicSupine positionSitting positionUltrasound pachymeterPatientsSignificant differencesSupineSimilar ratesSubjectsConsecutive measurementsEyesNeurodegeneration and Neuroprotection in Glaucoma.
Gauthier AC, Liu J. Neurodegeneration and Neuroprotection in Glaucoma. The Yale Journal Of Biology And Medicine 2016, 89: 73-9. PMID: 27505018, PMCID: PMC4797839.Peer-Reviewed Original ResearchConceptsCentral nervous system degenerative disorderOptic nerve degenerationRetinal ganglion cellsLateral geniculate nucleusAdenosine receptor antagonistIntraocular pressureNerve degenerationNeurotrophic factorReceptor antagonistGanglion cellsGlaucoma progressionDisease progressionIrreversible blindnessGeniculate nucleusNew therapiesVisual cortexDegenerative disordersAxonal transportCell therapyGlaucomaOxidative stressTherapyDiseaseNeuroprotectionNeurodegeneration
2015
Marijuana for Glaucoma: A Recipe for Disaster or Treatment?
Sun X, Xu CS, Chadha N, Chen A, Liu J. Marijuana for Glaucoma: A Recipe for Disaster or Treatment? The Yale Journal Of Biology And Medicine 2015, 88: 265-9. PMID: 26339209, PMCID: PMC4553646.Peer-Reviewed Original ResearchConceptsCannabis use disorderIntraocular pressureGlaucoma patientsGlaucoma treatmentAdverse effectsMost glaucoma patientsLower intraocular pressurePsychological adverse effectsTreatment of glaucomaNumerous adverse effectsSignificant adverse effectsWithdrawal symptomsPossible progressionUse disordersUse of marijuanaSubstance abuseMedical marijuanaRare circumstancesFurther studiesTreatmentPatientsGlaucomaCannabinoid moleculesMarijuanaDeleterious effectsResident and Fellow Glaucoma Surgical Experience Following the Tube Versus Trabeculectomy Study
Chadha N, Liu J, Teng CC. Resident and Fellow Glaucoma Surgical Experience Following the Tube Versus Trabeculectomy Study. Ophthalmology 2015, 122: 1953-1954. PMID: 25911055, DOI: 10.1016/j.ophtha.2015.03.009.Peer-Reviewed Original Research
2012
Focused ultrasound facilitated thermo-chemotherapy for targeted retinoblastoma treatment: A modeling study
Wang S, Mahesh SP, Liu J, Geist C, Zderic V. Focused ultrasound facilitated thermo-chemotherapy for targeted retinoblastoma treatment: A modeling study. Experimental Eye Research 2012, 100: 17-25. PMID: 22564972, DOI: 10.1016/j.exer.2012.04.009.Peer-Reviewed Original ResearchConceptsFocused ultrasoundType of treatmentVision preservationRetinoblastoma treatmentIntraocular tumorsTreatment paradigmRabbit eyesTumor areaEarly detectionTumorsVivo studiesRetinoblastomaHyperthermic temperature rangeCommon typeTreatmentDrug deliveryFUS parametersUltrasoundEye structuresHyperthermiaViable optionThermo-chemotherapyDeliveryTherapy