Epigenetics and Signaling Pathways in Glaucoma
Gauthier AC, Liu J. Epigenetics and Signaling Pathways in Glaucoma. BioMed Research International 2017, 2017: 5712341. PMID: 28210622, PMCID: PMC5292191, DOI: 10.1155/2017/5712341.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEpigenesis, GeneticGene Expression RegulationGlaucomaHumansMolecular Targeted TherapyRetinal NeuronsSignal TransductionTrabecular MeshworkVision, OcularConceptsPotential new therapeutic targetGeneration of fibrosisNovel therapeutic agentsNew therapeutic targetsAqueous humor drainageProapoptotic gene expressionRetinal neuronsIrreversible blindnessCommon causeHuman trialsTherapeutic targetAnimal modelsTrabecular meshworkTherapeutic agentsNeurodegenerative diseasesProsurvival factorBcl-2Rho-kinaseGlaucomaSignaling pathwaysPathway membersMAP kinaseGene expressionPathwayPreliminary success