2020
Maternal Stroke
Miller E, Leffert L. Maternal Stroke. 2020, 343-361. DOI: 10.1007/978-3-030-43477-9_25.Peer-Reviewed Original ResearchPregnancy-related strokeCerebral venous sinus thrombosisPosterior reversible encephalopathy syndromeReversible cerebral vasoconstriction syndromeArterial ischemic strokeCerebral vasoconstriction syndromeReversible encephalopathy syndromeVenous sinus thrombosisSetting of pregnancyCNS morbidityEncephalopathy syndromeHyperacute managementMaternal strokeHypertensive disordersSinus thrombosisIschemic strokePoststroke careHemorrhagic strokeSubarachnoid hemorrhageMaternal mortalityPostpartum womenHeart diseaseRisk factorsLeading causeStroke mechanism
2019
National Partnership for Maternal Safety: Consensus Bundle on Obstetric Care for Women With Opioid Use Disorder.
Krans EE, Campopiano M, Cleveland LM, Goodman D, Kilday D, Kendig S, Leffert LR, Main EK, Mitchell KT, O'Gurek DT, D'Oria R, McDaniel D, Terplan M. National Partnership for Maternal Safety: Consensus Bundle on Obstetric Care for Women With Opioid Use Disorder. Obstetrics And Gynecology 2019, 134: 365-375. PMID: 31306323, DOI: 10.1097/aog.0000000000003381.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersConsensus BundleMaternal safetySubstance useObstetric careMajor patient safety issuePatient safety bundlePerinatal Quality CollaborativesNeonatal health outcomesHealth carePregnancy-associated morbidityEvidence-based recommendationsWomen's health careHealth care providersMaternity care settingsQuality improvement initiativesPatient safety issuesHealth care servicesNational PartnershipPublic health crisisSafety bundleFetal safetyEvidence-based practicePostpartum women
2018
The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants
Leffert L, Butwick A, Carvalho B, Arendt K, Bates SM, Friedman A, Horlocker T, Houle T, Landau R, Dubois H, Fernando R, Houle T, Kopp S, Montgomery D, Pellegrini J, Smiley R, Toledo P. The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants. Anesthesia & Analgesia 2018, 126: 928-944. PMID: 29099429, DOI: 10.1213/ane.0000000000002530.Peer-Reviewed Original ResearchConceptsHigh-dose anticoagulantsConsensus statementMaternal deathsObstetric anesthesiaNeuraxial proceduresPerinatology Consensus StatementPharmacodynamics of anticoagulantsUse of thromboprophylaxisRisk-benefit discussionsKey preventive measuresObstetric populationObstetric surgeryCesarean deliveryNeuraxial analgesiaVenous thromboembolismAnesthetic managementObstetric patientsDifficult airwayNeuraxial anesthesiaGeneral anesthesiaPostpartum womenPregnant womenFetal harmPostpartum periodLeading cause
2016
Risk of Pregnancy-Associated Stroke Across Age Groups in New York State
Miller EC, Gatollari HJ, Too G, Boehme AK, Leffert L, Elkind MS, Willey JZ. Risk of Pregnancy-Associated Stroke Across Age Groups in New York State. JAMA Neurology 2016, 73: 1461-1467. PMID: 27775757, DOI: 10.1001/jamaneurol.2016.3774.Peer-Reviewed Original ResearchConceptsPregnancy-associated strokePregnant/postpartum womenRisk of strokeIncidence risk ratioRisk factorsPostpartum womenAge groupsNonpregnant womenStroke riskOlder womenCumulative riskAge-specific incidence ratiosPost partumCalendar year 2003Cerebral venous thrombosisStroke risk factorsTransient ischemic attackVascular risk factorsOverall median ageLogistic regression modelsActive smokingChronic hypertensionIschemic attackNPAS groupCerebrovascular events
2015
Treatment patterns and short-term outcomes in ischemic stroke in pregnancy or postpartum period
Leffert LR, Clancy CR, Bateman BT, Cox M, Schulte PJ, Smith EE, Fonarow GC, Kuklina EV, George MG, Schwamm LH. Treatment patterns and short-term outcomes in ischemic stroke in pregnancy or postpartum period. American Journal Of Obstetrics And Gynecology 2015, 214: 723.e1-723.e11. PMID: 26709084, DOI: 10.1016/j.ajog.2015.12.016.Peer-Reviewed Original ResearchConceptsAcute stroke reperfusion therapyStroke reperfusion therapyShort-term outcomesTissue plasminogen activatorGuidelines-Stroke registryPregnancy-related strokeReperfusion therapyIschemic stroke patientsIschemic strokeNonpregnant womenPostpartum womenStroke patientsPlasminogen activatorPostpartum periodIntravenous tissue plasminogen activator useIntravenous tissue plasminogen activatorFavorable short-term outcomesTissue plasminogen activator useAcute reperfusion therapyCatheter-based thrombolysisGreater stroke severityMajor systemic bleedingNonpregnant women 18Symptomatic intracranial hemorrhageHistory of hypertension
2013
Clinical care for opioid-using pregnant and postpartum women: the role of obstetric providers
Jones HE, Deppen K, Hudak ML, Leffert L, McClelland C, Sahin L, Starer J, Terplan M, Thorp JM, Walsh J, Creanga AA. Clinical care for opioid-using pregnant and postpartum women: the role of obstetric providers. American Journal Of Obstetrics And Gynecology 2013, 210: 302-310. PMID: 24120973, PMCID: PMC7213596, DOI: 10.1016/j.ajog.2013.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineConfidentialityDose-Response Relationship, DrugEmergency Service, HospitalFemaleHumansLabor PainLabor, ObstetricMental DisordersMethadoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPain, PostoperativePhysician-Patient RelationsPostnatal CarePregnancyPregnancy ComplicationsPrenatal CareReferral and ConsultationTriageConceptsPregnant womenObstetric providersPostpartum periodPregnant patientsMixed opioid agonist/antagonistOpioid-dependent pregnant patientsOpioid-dependent pregnant womenOpioid agonist/antagonistHigh-quality obstetric careMedication-assisted withdrawalTherapeutic opioid useAcute pain managementHigh relapse rateDrug use disordersClinical care issuesIntense medical careBest possible outcomeOpioid withdrawalOpioid usePain managementRelapse rateObstetric carePostpartum womenComprehensive careClinical care