2022
The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States
Katz D, Bateman B, Kjaer K, Turner D, Spence N, Habib A, George R, Toledano R, Grant G, Madden H, Butwick A, Lynde G, Minehart R, Beilin Y, Houle T, Sharpe E, Kodali B, Bharadwaj S, Farber M, Palanisamy A, Prabhu M, Gonzales N, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States. Obstetric Anesthesia Digest 2022, 42: 27-28. DOI: 10.1097/01.aoa.0000816828.87126.61.Peer-Reviewed Original ResearchThe relationship between INTEM/HEPTEM coagulation time ratio and heparin plasma concentration in obstetric patients: an exploratory in vitro investigation
Katz D, Leffert L, Getrajdman C, Sison M, Shin DW, Lin HM, Butwick A. The relationship between INTEM/HEPTEM coagulation time ratio and heparin plasma concentration in obstetric patients: an exploratory in vitro investigation. Journal Canadien D'anesthésie 2022, 69: 597-604. PMID: 35102496, DOI: 10.1007/s12630-022-02193-5.Peer-Reviewed Original ResearchConceptsObstetric patientsUnfractionated heparinConcentration of heparinHeparin activityHeparin concentrationPartial thromboplastin time (aPTT) testingCT ratioCare coagulation testsHeparin plasma concentrationsResultsSeventy-seven patientsPartial thromboplastin timeUncomplicated pregnanciesThird trimesterNeuraxial anestheticPlasma concentrationsCoagulation testsThromboplastin timeBlood samplesPatientsHeparinAPTTHematocrit rangeVitro investigationBloodTime ratio
2021
Pragmatic Approach to Neuraxial Anesthesia in Obstetric Patients With Disorders of the Vertebral Column, Spinal Cord, and Neuromuscular System
Walsh E, Zhang Y, Madden H, Lehrich J, Leffert L. Pragmatic Approach to Neuraxial Anesthesia in Obstetric Patients With Disorders of the Vertebral Column, Spinal Cord, and Neuromuscular System. Obstetric Anesthesia Digest 2021, 41: 164-165. DOI: 10.1097/01.aoa.0000796068.53863.3d.Peer-Reviewed Original Research
2020
Pragmatic approach to neuraxial anesthesia in obstetric patients with disorders of the vertebral column, spinal cord and neuromuscular system
Walsh E, Zhang Y, Madden H, Lehrich J, Leffert L. Pragmatic approach to neuraxial anesthesia in obstetric patients with disorders of the vertebral column, spinal cord and neuromuscular system. Regional Anesthesia & Pain Medicine 2020, 46: 258-267. PMID: 33115718, DOI: 10.1136/rapm-2020-101792.Peer-Reviewed Original ResearchConceptsNeuraxial anesthesiaObstetric patientsSpinal cordCesarean delivery anesthesiaCesarean deliveryLabor analgesiaNeuraxial analgesiaVertebral columnCase seriesGeneral anesthesiaObstetrical patientsRetrospective studyDelivery anesthesiaPatient injuryAnesthesiaPatient harmPatientsNarrative reviewAvailable evidenceUnwarranted fearsNeuromuscular systemAdditional riskPresent unique challengesAnalgesiaCordLumbar Neuraxial Procedures in Thrombocytopenic Patients Across Populations: A Systematic Review and Meta-analysis
Bauer M, Toledano R, Houle T, Beilin Y, MacEachern M, McCabe M, Rector D, Cooper J, Gernsheimer T, Landau R, Leffert L. Lumbar Neuraxial Procedures in Thrombocytopenic Patients Across Populations: A Systematic Review and Meta-analysis. Obstetric Anesthesia Digest 2020, 40: 118-118. DOI: 10.1097/01.aoa.0000693644.32975.42.Peer-Reviewed Original ResearchNeuraxial anesthetic proceduresSpinal epidural hematomaEpidural hematomaThrombocytopenic patientsNeuraxial proceduresAnesthetic proceduresSystematic reviewThreshold platelet countCesarean deliveryFetal factorsNeuraxial anesthesiaGeneral anesthesiaPlatelet countSide effectsMeta-AnalysisHematomaPatientsAnesthesiaReviewPopulation
2019
Acute Fatty Liver of Pregnancy: Pathophysiology, Anesthetic Implications, and Obstetrical Management.
Naoum EE, Leffert LR, Chitilian HV, Gray KJ, Bateman BT. Acute Fatty Liver of Pregnancy: Pathophysiology, Anesthetic Implications, and Obstetrical Management. Anesthesiology 2019, 130: 446-461. PMID: 30707120, PMCID: PMC7037575, DOI: 10.1097/aln.0000000000002597.Peer-Reviewed Original Research
2018
The Role of the Anesthesiologist in Preventing Severe Maternal Morbidity and Mortality
McQUAID E, Leffert LR, Bateman BT. The Role of the Anesthesiologist in Preventing Severe Maternal Morbidity and Mortality. Clinical Obstetrics & Gynecology 2018, 61: 372-386. PMID: 29319586, DOI: 10.1097/grf.0000000000000350.Peer-Reviewed Original ResearchMeSH KeywordsAirway ManagementAnesthesia, EpiduralAnesthesia, GeneralAnesthesiologistsAnesthetics, LocalBlood TransfusionEchocardiographyEpidural AbscessFemaleHeadacheHematoma, Epidural, SpinalHumansIntubation, IntratrachealMaternal DeathMeningitisMonitoring, PhysiologicObstetric Labor ComplicationsPhysician's RolePregnancyPuerperal DisordersRespiratory AspirationRisk FactorsConceptsObstetric anesthesiologistSevere maternal morbidityLife-saving interventionsMaternal morbidityCesarean deliveryUnstable patientsGeneral anesthesiaObstetric suiteObstetric proceduresBedside managementClinical scenariosAnesthesiologistsIntensivistsAnesthesiaGreater experienceDeliveryAnalgesiaMorbidityPatientsUnique roleMortalityCliniciansNeuraxial Anesthesia in Obstetric Patients Receiving Thromboprophylaxis With Unfractionated or Low–Molecular-Weight Heparin
Leffert L, Dubois H, Butwick A, Carvalho B, Houle T, Landau R. Neuraxial Anesthesia in Obstetric Patients Receiving Thromboprophylaxis With Unfractionated or Low–Molecular-Weight Heparin. Obstetric Anesthesia Digest 2018, 38: 3-4. DOI: 10.1097/01.aoa.0000529964.63597.d5.Peer-Reviewed Original ResearchSpinal epidural hematomaObstetric patientsNeuraxial anesthesiaWeight heparinVenous thromboembolismCesarean deliveryEpidural hematomaPregnant womenNeuraxial blockadeNational guidelinesPatientsThromboprophylaxisHeparinAnesthesiaSafe useWomenLow-MolecularThromboembolismHematomaBlockadeReview reportsPresent review reports
2017
Integrating the New Thromboprophylaxis Guidelines Into Obstetric Anesthesia Practice
Leffert L, Landau R. Integrating the New Thromboprophylaxis Guidelines Into Obstetric Anesthesia Practice. Survey Of Anesthesiology 2017, 61: 14. DOI: 10.1097/01.sa.0000513496.39516.43.Peer-Reviewed Original ResearchVenous thromboembolismPatient care recommendationsObstetric anesthesia practiceConsensus BundleThromboprophylaxis guidelinesVTE ratesMaternal deathsNeuraxial anesthesiaObstetric patientsObstetric anesthesiaCare recommendationsAnesthesia practiceAnesthesiaNational PartnershipRiskThromboembolismPatients
2015
What’s new in obstetric anesthesia? Focus on preeclampsia
Leffert L. What’s new in obstetric anesthesia? Focus on preeclampsia. International Journal Of Obstetric Anesthesia 2015, 24: 264-271. PMID: 25936785, DOI: 10.1016/j.ijoa.2015.03.008.Peer-Reviewed Original ResearchConceptsMulti-organ systemsHigh-risk patientsPrevalence of preeclampsiaDefinition of preeclampsiaObstetric care teamPregnant patientsFetal effectsObstetric anesthesiaClinical managementCare teamPreeclampsiaTherapeutic interventionsPatientsContemporary dataRecent updatesComorbiditiesMorbidityPregnancyAnesthesiaPathogenesisEtiologyFetusesPrevalenceDiagnosisCare
2014
Cardiac Arrest during Hospitalization for Delivery in the United States, 1998–2011
Mhyre JM, Tsen LC, Einav S, Kuklina EV, Leffert LR, Bateman BT. Cardiac Arrest during Hospitalization for Delivery in the United States, 1998–2011. Anesthesiology 2014, 120: 810-818. PMID: 24694844, PMCID: PMC4445354, DOI: 10.1097/aln.0000000000000159.Peer-Reviewed Original ResearchConceptsAmniotic fluid embolismCardiac arrestPotential etiologiesHeart failureCommon potential etiologyMaternal cardiac arrestNationwide Inpatient SampleDemographic risk factorsMaternal cardiopulmonary arrestHospital dischargeCardiopulmonary arrestU.S. hospitalizationsUnderlying etiologyInpatient SampleMaternal arrestRisk factorsHospitalizationSurvival rateEtiologySepsisEmbolismHemorrhageArrestPatientsSurvival
2008
833: Non-invasive cardiovascular profiling: Differences between patients with preeclampsia and those with gestational hypertension
Katz D, Ecker J, Leffert L, Pian-Smith M. 833: Non-invasive cardiovascular profiling: Differences between patients with preeclampsia and those with gestational hypertension. American Journal Of Obstetrics And Gynecology 2008, 199: s235. DOI: 10.1016/j.ajog.2008.09.864.Peer-Reviewed Original Research