2006
Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis
Rakoff-Nahoum S, Hao L, Medzhitov R. Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis. Immunity 2006, 25: 319-329. PMID: 16879997, DOI: 10.1016/j.immuni.2006.06.010.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseToll-like receptorsAbsence of TLRDevelopment of IBDEtiology of IBDImmune systemIL-10-deficient miceImmune suppressive mechanismsInnate immune recognitionHost immune systemBowel diseaseIntestinal inflammationColitisCommensal microfloraImmune recognitionMiceMultiple mechanismsDisease susceptibilityDifferential rolesReceptorsInflammationInterleukinMicrofloraEtiologyDisease
2002
Murine model of gastrointestinal ischemia associated with complement-dependent injury
Zhao H, Montalto MC, Pfeiffer KJ, Hao L, Stahl GL. Murine model of gastrointestinal ischemia associated with complement-dependent injury. Journal Of Applied Physiology 2002, 93: 338-345. PMID: 12070223, DOI: 10.1152/japplphysiol.00159.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsColoring AgentsComplement C5Complement System ProteinsDigestive SystemGastrointestinal DiseasesImmunohistochemistryIntercellular Adhesion Molecule-1IntestinesL-Lactate DehydrogenaseLungMaleMiceMice, Inbred C57BLMice, KnockoutPeroxidaseRegional Blood FlowReperfusion InjuryReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionConceptsRemote tissue injuryTissue injuryGastrointestinal ischemiaMurine modelComplement-mediated tissue injuryIntercellular adhesion molecule-1 mRNAAnti-C5 treatmentComplement-dependent injuryInflammatory protein-2 mRNAIschemia-reperfusion injuryAttenuates tissue injuryNew murine modelC5 monoclonal antibodyNeutrophil accumulationNeutrophil infiltrationNeutrophil recruitmentProtein-2 mRNAChemokine expressionActivate complementInjuryAdherence moleculesComplement activationMonoclonal antibodiesProtein expressionLactate dehydrogenase