2009
Children with Tourette's Syndrome May Suffer Immunoglobulin A Dysgammaglobulinemia: Preliminary Report
Kawikova I, Grady BP, Tobiasova Z, Zhang Y, Vojdani A, Katsovich L, Richmand BJ, Park TW, Bothwell AL, Leckman JF. Children with Tourette's Syndrome May Suffer Immunoglobulin A Dysgammaglobulinemia: Preliminary Report. Biological Psychiatry 2009, 67: 679-683. PMID: 20006327, PMCID: PMC3974615, DOI: 10.1016/j.biopsych.2009.09.034.Peer-Reviewed Original ResearchMeSH KeywordsChildDysgammaglobulinemiaEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MMaleTourette SyndromeConceptsUpper respiratory tract infectionEnzyme-linked immunosorbent assayControl subjectsOCD patientsSex-matched control subjectsRespiratory tract infectionsAntineuronal antibodiesSpecific IgATract infectionsHealthy ageSydenham's choreaTotal IgAMultiple sclerosisObsessive-compulsive disorderSpecific IgGTotal immunoglobulinImmune deficiencyPostinfectious autoimmunityTourette syndromePatientsImmunosorbent assayIgAChoreaSyndromeAntigen
2005
Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome
Leckman JF, Katsovich L, Kawikova I, Lin H, Zhang H, Krönig H, Morshed S, Parveen S, Grantz H, Lombroso PJ, King RA. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome. Biological Psychiatry 2005, 57: 667-673. PMID: 15780855, DOI: 10.1016/j.biopsych.2004.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCase-Control StudiesChildCytokinesEnzyme-Linked Immunosorbent AssayFemaleHumansInterleukin-12Longitudinal StudiesMaleProspective StudiesTourette SyndromeTumor Necrosis Factor-alphaConceptsEarly-onset obsessive-compulsive disorderObsessive-compulsive disorderSymptom exacerbationInterleukin-12Control subjectsImmune responseTourette syndromeTumor necrosis factor-alpha concentrationsNecrosis factor-alpha concentrationsAge-matched control subjectsInvolvement of innateLocal cytokine synthesisT cell immunityHumoral immune responseCentral nervous systemInnate immune responseLongitudinal studyProspective longitudinal studyT cell activationCell immunitySerum levelsPediatric populationCommon infectionsSerum concentrationsInflammatory process