2014
Randomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome
Landeros-Weisenberger A, Mantovani A, Motlagh MG, de Alvarenga PG, Katsovich L, Leckman JF, Lisanby SH. Randomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome. Brain Stimulation 2014, 8: 574-581. PMID: 25912296, PMCID: PMC4454615, DOI: 10.1016/j.brs.2014.11.015.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationSham repetitive transcranial magnetic stimulationSupplementary motor areaLow-frequency repetitive transcranial magnetic stimulationFrequency repetitive transcranial magnetic stimulationActive repetitive transcranial magnetic stimulationSevere Tourette syndromeTranscranial magnetic stimulationTourette syndromeTic severityMagnetic stimulationDouble-blind sham-controlled trialEfficacy of rTMSOpen-label active treatmentYGTSS total tic scoreAlternative stimulation protocolsDouble-blind trialOpen-label studySham-controlled trialTotal tic scoreActive rTMS treatmentRandomized ShamRTMS treatmentActive treatmentMotor threshold
2012
Tourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder
Lebowitz ER, Motlagh MG, Katsovich L, King RA, Lombroso PJ, Grantz H, Lin H, Bentley MJ, Gilbert DL, Singer HS, Coffey BJ, the Tourette Syndrome Study Group, Kurlan RM, Leckman JF. Tourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 2012, 21: 451-457. PMID: 22543961, PMCID: PMC3722559, DOI: 10.1007/s00787-012-0278-5.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderComorbid tic disordersObsessive-compulsive disorderSeverity of ticsChronic tic disorderTic disordersPsychosocial stressDeficit hyperactivity disorderGlobal functioningComorbid diagnosesHyperactivity disorderMore severe ticsComorbid attention deficit hyperactivity disorderDiagnosis of OCDComorbid obsessive-compulsive disorderAdditional comorbid diagnosesSymptoms of anxietyHigh psychosocial stressMore internalizing disordersGreater psychosocial stressSevere ticsOppositional defiant disorderSevere subtypeTic severityTourette syndrome
2006
Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder
Lin H, Katsovich L, Ghebremichael M, Findley DB, Grantz H, Lombroso PJ, King RA, Zhang H, Leckman JF. Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder. Journal Of Child Psychology And Psychiatry 2006, 48: 157-166. PMID: 17300554, PMCID: PMC3073143, DOI: 10.1111/j.1469-7610.2006.01687.x.Peer-Reviewed Original ResearchConceptsDepressive symptom severityFuture depressive symptomsHealthy control subjectsObsessive-compulsive disorderDepressive symptomsPsychosocial stressTourette syndromeSymptom severityControl subjectsLong-term contextual threatSeverity of ticsProspective longitudinal studyChronological ageIndependent predictorsOC symptomsTic severityOC symptom severityPsychosocial adversitySymptomsFuture symptom severityClinician ratingsSeverityParental reportsSignificant predictorsLongitudinal study