2020
Stage-dependent Increase in Expression of miR-155 and Ki-67 and Number of Tumour-associated Inflammatory Cells in Folliculotropic Mycosis Fungoides
ATZMONY L, MOYAL L, FEINMESSER M, GOROVITZ B, HIRSHBERG A, AMITAY-LAISH I, PRAG-NAVEH H, BARZILAI A, HODAK E. Stage-dependent Increase in Expression of miR-155 and Ki-67 and Number of Tumour-associated Inflammatory Cells in Folliculotropic Mycosis Fungoides. Acta Dermato Venereologica 2020, 100: 5828. PMID: 32556361, PMCID: PMC9207631, DOI: 10.2340/00015555-3578.Peer-Reviewed Original ResearchConceptsFolliculotropic mycosis fungoidesMycosis fungoidesKi-67Inflammatory cellsCD20+ B cellsTumor-associated inflammatory cellsTumor-infiltrating inflammatory cellsVariant of mycosis fungoidesEarly-stage MFTumour cell immunoreactivityCD68+ macrophagesMiR-155 expressionTumor-stage MFStage-dependent increaseStatistically significant differenceIndolent stageMiR-155Clinicopathological stageCell immunoreactivityB cellsInflammatory dermatosesImmunohistochemical analysisProliferating lymphocytesFungoidesSignificant difference
2019
Phenotypic expansion of POFUT1 loss of function mutations in a disorder featuring segmental dyspigmentation with eczematous and folliculo‐centric lesions
Atzmony L, Zaki TD, Antaya RJ, Choate KA. Phenotypic expansion of POFUT1 loss of function mutations in a disorder featuring segmental dyspigmentation with eczematous and folliculo‐centric lesions. American Journal Of Medical Genetics Part A 2019, 179: 2469-2473. PMID: 31566882, PMCID: PMC7914397, DOI: 10.1002/ajmg.a.61362.Peer-Reviewed Original ResearchConceptsDowling-Degos diseasePhenotypic expansionMosaic disordersFunction mutationsDistinct clinical presentationsSomatic copy-neutral lossGermline heterozygous mutationsWhole-exome sequencingClinical presentationEczematous plaquesFollicular papulesAffected skinSkin diseasesBlaschko's linesCopy-neutral lossHeterozygous mutationsReticulated hyperpigmentationExome sequencingNormal keratinocytesPostzygotic mutationDisordersExpression levelsSomatic mutationsLesionsKeratinocytes