2022
CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary.
Melero I, Sanmamed M, Glez-Vaz J, Luri-Rey C, Wang J, Chen L. CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary. Cancer Discovery 2022, 13: 552-569. PMID: 36576322, DOI: 10.1158/2159-8290.cd-22-1029.Peer-Reviewed Original ResearchConceptsAnti-CD137 monoclonal antibodiesT cell antitumor immunitySevere liver inflammationTolerable safety profileCancer immunotherapy strategiesNatural killer lymphocytesSingle-agent activityNon-Hodgkin lymphomaEarly phase trialsChimeric antigen receptorCD137 agonistsEnhanced CD8Unacceptable toxicityAntitumor immunityLiver inflammationImmunotherapy strategiesSafety profileCancer immunotherapyKiller lymphocytesClinical activityAgonist antibodyPharmacodynamic activityMouse modelCD137Costimulatory receptors
2019
PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus
Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, Kim TK, Moeckel GW, McNiff JM, Chen L. PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus. Science Translational Medicine 2019, 11 PMID: 31826980, DOI: 10.1126/scitranslmed.aax1159.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArthritisAutoantibodiesAutoimmunityDendritic CellsHumansInflammationInterferon Type ILupus Erythematosus, CutaneousLupus Erythematosus, SystemicMembrane ProteinsMice, Inbred BALB CMice, Inbred MRL lprMyeloid CellsNeutrophilsReceptors, Antigen, T-CellSignal TransductionTerpenesUp-RegulationConceptsPlasmacytoid dendritic cellsDiscoid lupus erythematosusSystemic lupus erythematosusCutaneous lupus lesionsPD-1HLupus erythematosusLupus lesionsAutoimmune diseasesKO miceT cellsMyeloid cellsHuman systemic lupus erythematosusBALB/c backgroundCutaneous lupus erythematosusInappropriate immune responseProgression of lupusSystemic autoimmune diseaseImmune cell expansionSuppression of autoimmunityAgonistic monoclonal antibodyDeath-1 homologCutaneous lupusProinflammatory neutrophilsDendritic cellsDLE lesions