2017
An engineered cell-imprinted substrate directs osteogenic differentiation in stem cells
Kamguyan K, Katbab A, Mahmoudi M, Thormann E, Zajforoushan Moghaddam S, Moradi L, Bonakdar S. An engineered cell-imprinted substrate directs osteogenic differentiation in stem cells. Biomaterials Science 2017, 6: 189-199. PMID: 29189838, DOI: 10.1039/c7bm00733g.Peer-Reviewed Original ResearchMeSH KeywordsBone and BonesCell DifferentiationCells, CulturedHumansMesenchymal Stem CellsMicroscopy, Atomic ForceOsteoblastsOsteogenesisConceptsStem cell osteogenic differentiationNanocomposite substrateCell osteogenic differentiationCell-imprinted substratesAtomic force microscopyWater contact angle measurementsOsteogenic differentiationNanoscale resolutionCultured stem cellsHydroxyapatite nanoparticlesContact angle measurementsDynamic mechanical thermal analysisForce microscopyStem cellsStem cell differentiationMechanical thermal analysisGene expression analysisElectron microscopyAngle measurementsChemical signalingExpression analysisOsteogenic differentiation capacityAlizarin red stainingChemical signalsCell differentiation
2016
Epidermal growth factor receptor targeting alters gene expression and restores the adhesion function of cancerous cells as measured by single cell force spectroscopy
Azadi S, Tafazzoli-Shadpour M, Omidvar R, Moradi L, Habibi-Anbouhi M. Epidermal growth factor receptor targeting alters gene expression and restores the adhesion function of cancerous cells as measured by single cell force spectroscopy. Molecular And Cellular Biochemistry 2016, 423: 129-139. PMID: 27696309, DOI: 10.1007/s11010-016-2831-x.Peer-Reviewed Original ResearchConceptsCell-cell adhesionE-cadherin expressionEpidermal growth factor receptorGrowth factor receptorAdhesion functionCell-cell adhesion forcesCell-cell adhesion functionSingle-cell force spectroscopyFactor receptorAlters gene expressionCell force spectroscopyE-cadherin geneTime PCR analysisBlockade of EGFRTreatment of cellsForce spectroscopy techniquesHuman epithelial cancer cell linesEpithelial cancer cell linesCancerous cellsCell mechanical propertiesEGFR activityGene expressionCell behaviorInhibition of metastasisCancer progression