Modulatory Role of SIRT1 and Resistin as Therapeutic Targets in Patients with Aortic Valve Stenosis
Samiei N, Hosseini S, Maleki M, Moradi L, Joghataei M, Arabian M. Modulatory Role of SIRT1 and Resistin as Therapeutic Targets in Patients with Aortic Valve Stenosis. Archives Of Medical Research 2019, 50: 333-341. PMID: 31677538, DOI: 10.1016/j.arcmed.2019.10.001.Peer-Reviewed Original ResearchConceptsSilent information regulator 1Aortic valve stenosisPeripheral blood mononuclear cellsResistin levelsValve stenosisAS groupExpression of SIRT1Modulatory roleAortic valve replacementLevels of resistinBlood mononuclear cellsInformation regulator 1Effects of resveratrolAS preventionValve replacementPharmacological therapyMononuclear cellsResistin expressionSIRT1 expressionTargeted therapySIRT1 levelsTherapeutic effectHealthy subjectsNovel biomarkersTherapeutic target