2024
SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5
Qi J, Yan L, Sun J, Huang C, Su B, Cheng J, Shen L. SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2314619121. PMID: 38776375, PMCID: PMC11145296, DOI: 10.1073/pnas.2314619121.Peer-Reviewed Original ResearchConceptsPaired box protein 5GC B cellsSUMO-specific protease 1Activation-induced cytidine deaminaseProtein SUMOylationClass switch recombinationProtein stabilityB cellsProtease 1B cell responsesProtein 5Cytidine deaminaseSENP1Up-regulatedGC B cell responsesSomatic hypermutationSUMOylationDeSUMOylationGerminal centersHigher affinityProduction of class-switched antibodiesGerminal center B cell responsesGC reactionMemory B cellsClass-switched antibodies
2019
Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc
Li M, Lazorchak AS, Ouyang X, Zhang H, Liu H, Arojo OA, Yan L, Jin J, Han Y, Qu G, Fu Y, Xu X, Liu X, Zhang W, Yang Z, Ruan C, Wang Q, Liu D, Huang C, Lu L, Jiang S, Li F, Su B. Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc. Cellular & Molecular Immunology 2019, 16: 757-769. PMID: 30705387, PMCID: PMC6804816, DOI: 10.1038/s41423-018-0185-x.Peer-Reviewed Original ResearchConceptsCell growthActivation of mTORC2MTOR complex 2B cell growthAkt-dependent inactivationC-myc proteinMolecular mechanismsSIN1Molecular levelGenetic ablationB cell-mediated immunitySpecific roleCell sizeMetabolismB cell proliferationComplexes 2GrowthAnti-viral immunityMTORC2GSK3B cellsMYCKey componentProteinTransitional stage