2024
Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Wang P, Yang X, Zhang L, Sha S, Huang J, Peng J, Gu J, Pearson J, Hu Y, Zhao H, Wong F, Wang Q, Wen L. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 2024, 15: 4232. PMID: 38762479, PMCID: PMC11102548, DOI: 10.1038/s41467-024-48611-8.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Gut microbiotaGut microbial communityTransferred to germ-free miceB cellsGerm-free miceTLR9 deficiencyKO miceGene sequencesGerminal center B cellsMicrobial communitiesMarginal zone B cellsGut dysbiosisFollicular helper cellsSelf-DNAMetabolic homeostasisAssociated with increased frequencyPro-inflammatory stateFat tissue inflammationGutHigh-fat dietMicrobiotaHelper cellsT cellsControl mice
2020
Crosstalk between circadian rhythms and the microbiota
Pearson JA, Wong FS, Wen L. Crosstalk between circadian rhythms and the microbiota. Immunology 2020, 161: 278-290. PMID: 33090484, PMCID: PMC7692254, DOI: 10.1111/imm.13278.Peer-Reviewed Original ResearchConceptsHost circadian rhythmsMicrobial oscillationsGene/protein expressionAspects of biologyCircadian rhythmMicrobial associationsMolecular oscillationsCircadian oscillationsMicrobial compositionMicrobial influenceCause diseaseMolecular techniquesHost metabolismDisease susceptibilityMicrobial changesProtein expressionPeripheral rhythmsMain inducerMicrobiotaSleep-wake cycleHost immunityCrosstalkClinical successPotential connectionMicrobes