2017
Folate-mediated chemotherapy and diagnostics: An updated review and outlook
Xu L, Bai Q, Zhang X, Yang H. Folate-mediated chemotherapy and diagnostics: An updated review and outlook. Journal Of Controlled Release 2017, 252: 73-82. PMID: 28235591, PMCID: PMC5479736, DOI: 10.1016/j.jconrel.2017.02.023.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFolate receptorCellular uptake mechanismVivo applicationsDiagnostic agentsNanomedicineNanoprobeTremendous effortsNanoparticlesMajor challengeClinical applicationAdministration routeDiagnosticsChemotherapyApplicationsHuman cancersLatest developmentsUptake mechanismPharmacokineticsConcise reviewRouteReview
2016
Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells
Xu L, Kittrell S, Yeudall WA, Yang H. Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells. Nanomedicine 2016, 11: 2959-2973. PMID: 27781559, PMCID: PMC5144492, DOI: 10.2217/nnm-2016-0244.Peer-Reviewed Original ResearchConceptsNeck cancer cellsCancer cellsFR-dependent mannerEnhanced gene expressionGene expressionSame binding siteCellular uptakeGenesDelivery of genesBinding sitesHigh expressionFree FASuitable vectorPlasmidDNA plasmidsCellsTransfection resultsExpressionTransfection efficiencySelective uptakeUptakeFolate receptorHigh levelsVectorFA