Clinical Presentation, Response to Therapy, and Outcome of Gastroparesis in Children
Rodriguez L, Irani K, Jiang H, Goldstein AM. Clinical Presentation, Response to Therapy, and Outcome of Gastroparesis in Children. Journal Of Pediatric Gastroenterology And Nutrition 2012, 55: 185-190. PMID: 22228004, DOI: 10.1097/mpg.0b013e318248ed3f.Peer-Reviewed Original ResearchConceptsPediatric gastroparesisPostviral gastroparesisPromotility therapySymptom resolutionClinical featuresMitochondrial dysfunctionYounger ageOutcomes of gastroparesisMore vomitingPromotility drugsAbdominal painClinical presentationMedian timeRetrospective reviewMale sexMean ageEffective therapyGastroparesisVariable symptomatologyMultivariate analysisTherapySymptomsMonthsLonger durationOverall rateEndoscopic intrapyloric injection of botulinum toxin A in the treatment of children with gastroparesis: a retrospective, open-label study
Rodriguez L, Rosen R, Manfredi M, Nurko S. Endoscopic intrapyloric injection of botulinum toxin A in the treatment of children with gastroparesis: a retrospective, open-label study. Gastrointestinal Endoscopy 2012, 75: 302-309. PMID: 22248598, PMCID: PMC3260460, DOI: 10.1016/j.gie.2011.09.042.Peer-Reviewed Original ResearchConceptsOpen-label studyBotulinum toxin APredictive factorsToxin ASingle tertiary care centerLong-term clinical outcomesRefractory gastroparesis symptomsSymptoms of gastroparesisPlacebo-controlled trialTertiary care centerManagement of childrenSingle case reportsTreatment of childrenGastroparesis refractoryGastroparesis symptomsIntrapyloric injectionReported exacerbationsSpastic disordersClinical improvementMedian durationOlder patientsBotulinum injectionMale patientsMedical therapyRetrospective review