2023
Clinical Utility of Ileal Motility in Children With Defecation Disorders and Children With Chronic Intestinal Pseudo‐Obstruction
Colliard K, Nurko S, Flores A, Rodriguez L. Clinical Utility of Ileal Motility in Children With Defecation Disorders and Children With Chronic Intestinal Pseudo‐Obstruction. Journal Of Pediatric Gastroenterology And Nutrition 2023, 77: 327-331. PMID: 37229777, DOI: 10.1097/mpg.0000000000003841.Peer-Reviewed Original ResearchConceptsAntroduodenal manometryDefecation disordersPostprandial responseGroup BChronic Intestinal Pseudo-ObstructionIntestinal Pseudo-ObstructionNormal postprandial responseModerate agreementSmall bowel motilityLogistic regression analysisOstomy closurePseudo-ObstructionBowel motilityRetrospective reviewIleal motilityIndication groupGroup AClinical utilityYounger agePatientsMotility patternsPhase IIIMotor complexDisordersManometry
2022
Diverting Ileostomy in Children With Functional Constipation
Rodriguez L, Colliard K, Nurko S, Flores A, Buchmiller TL. Diverting Ileostomy in Children With Functional Constipation. Journal Of Pediatric Gastroenterology And Nutrition 2022, 75: 578-583. PMID: 35897140, DOI: 10.1097/mpg.0000000000003579.Peer-Reviewed Original ResearchConceptsFunctional constipationOstomy closurePediatric functional constipationInstitutional review board approvalReview board approvalEnema failureColon motilityFurther surgeryInvasive evaluationRetrospective studySurgical interventionOstomyBoard approvalUseful interventionLarger studyConstipationSuccessful responsePatientsSurgeryChildrenRole of CMDemographicsAssociationInterventionIndications
2021
Upper Gastrointestinal Functional and Motility Disorders in Children
Miller J, Khlevner J, Rodriguez L. Upper Gastrointestinal Functional and Motility Disorders in Children. Pediatric Clinics Of North America 2021, 68: 1237-1253. PMID: 34736587, DOI: 10.1016/j.pcl.2021.07.009.Peer-Reviewed Original ResearchConceptsMotility disordersNew diagnostic studiesUpper gastrointestinal tractAbdominal painChest painMechanisms of diseaseClinical presentationMotor functionGastrointestinal tractGastrointestinal physiologyTherapeutic interventionsDiagnostic studiesDisordersNormal functionPainChildrenDysphagiaNauseaVomitingDysfunctionEsophagusSymptomsStomachDiseaseDiagnosisLower Gastrointestinal Functional and Motility Disorders in Children
Arbizu R, Freiberg B, Rodriguez L. Lower Gastrointestinal Functional and Motility Disorders in Children. Pediatric Clinics Of North America 2021, 68: 1255-1271. PMID: 34736588, DOI: 10.1016/j.pcl.2021.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnorectal MalformationsBiopsyChildChild, PreschoolColonic DiseasesConstipationErythromycinFemaleGastrointestinal DiseasesGastrointestinal MotilityHirschsprung DiseaseHumansInfantIntestinal Pseudo-ObstructionIntestine, SmallLower Gastrointestinal TractMaleManometryNutritional StatusQuality of LifeConceptsMotility disordersSignificant morbidityTherapeutic interventionsColorectal disordersPediatric gastroenterologistsClinical presentationSmall bowelGastrointestinal disordersCommon complaintDiagnostic evaluationSmall intestineDisordersMorbidityComplicationsSuch interventionsInterventionSocial stigmaPoor qualityBowelAnorectumGastroenterologistsColonMortalityComplaintsIntestineMelanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation
Chen JJ, Kitzia Colliard RN, Nurko S, Rodriguez L. Melanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation. Digestive Diseases And Sciences 2021, 67: 3922-3928. PMID: 34379221, DOI: 10.1007/s10620-021-07191-z.Peer-Reviewed Original ResearchConceptsPediatric functional constipationMelanosis coliFunctional constipationColonic manometryColonic motilityMarker of severityTreatment of constipationRate of surgeryColonic dysmotilityColonic biopsiesMedian agePediatric patientsManometry resultsMedication historyMethodsProspective studyPatient groupResultsA totalSurgical historyPathologic resultsConstipationPatientsCatheter positionDemographic dataSubsequent needSignificant differences
2020
Diagnostic and clinical utility of the wireless motility capsule in children: A study in patients with functional gastrointestinal disorders
Rodriguez L, Heinz N, Colliard K, Amicangelo M, Nurko S. Diagnostic and clinical utility of the wireless motility capsule in children: A study in patients with functional gastrointestinal disorders. Neurogastroenterology & Motility 2020, 33: e14032. PMID: 33184926, DOI: 10.1111/nmo.14032.Peer-Reviewed Original ResearchConceptsWireless motility capsuleColon transitGastrointestinal symptomsCapsule retentionMotility capsuleLower gastrointestinal symptomsRadiopaque marker studiesFunctional gastrointestinal symptomsFunctional gastrointestinal disordersNuclear medicine gastricGastrointestinal motilityGastrointestinal disordersTransit abnormalitiesClinical utilityGastric transitSymptomsLarger studyPatientsInterpretation agreementMarker studiesMotility parametersStudy interpretationCROMSignificant correlationChildren
2018
Same day versus next day antroduodenal manometry results in children with upper gastrointestinal symptoms: A prospective study
Arbizu RA, Nurko S, Heinz N, Amicangelo M, Rodriguez L. Same day versus next day antroduodenal manometry results in children with upper gastrointestinal symptoms: A prospective study. Neurogastroenterology & Motility 2018, 31: e13521. PMID: 30537362, DOI: 10.1111/nmo.13521.Peer-Reviewed Original ResearchConceptsSmall bowel motility indexDay 1Day 2Motility indexAbnormal studiesCatheter placementNormal studiesPhase IIIStudy interpretationChallenge phaseUpper gastrointestinal symptomsProportion of patientsGastrointestinal symptomsManometry resultsPostprandial responseProspective studyManometry parametersPatientsStudy parametersMotor complexSame dayAntrumDaysAnesthesiaCatheterThoracoscopic esophagomyotomy for achalasia in the pediatric population: A retrospective cohort study
Duggan EM, Nurko S, Smithers CJ, Rodriguez L, Fox VL, Fishman SJ. Thoracoscopic esophagomyotomy for achalasia in the pediatric population: A retrospective cohort study. Journal Of Pediatric Surgery 2018, 54: 572-576. PMID: 30121126, DOI: 10.1016/j.jpedsurg.2018.07.013.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyThoracoscopic esophagomyotomyPneumatic dilationCohort studyPediatric populationLength of stayInitial symptom reliefInvasive esophagomyotomyPreoperative dilationPostoperative painRecurrent symptomsMucosal injuryLaparoscopic approachSymptom reliefMedian lengthStandard treatmentEndoscopic guidanceOpen procedureEsophagomyotomyRare diseasePatientsAchalasiaEffective procedureDilationFundoplication
2017
Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation
Arbizu RA, Nurko S, Heinz N, Amicangelo M, Rodriguez L. Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation. Neurogastroenterology & Motility 2017, 29 PMID: 28317231, PMCID: PMC5466533, DOI: 10.1111/nmo.13050.Peer-Reviewed Original ResearchConceptsDay 1Day 2Normal studiesAbnormal studiesProportion of patientsSame dayStudy interpretationColon manometryGastrocolonic responseRefractory constipationProspective evaluationManometry parametersMotility indexPatientsChallenge phaseAbstractTextAnesthesiaCatheterStudy parametersColonoscopyDaysConstipationHAPCsManometryStudy
2016
Pediatric rumination subtypes: A study using high‐resolution esophageal manometry with impedance
Rosen R, Rodriguez L, Nurko S. Pediatric rumination subtypes: A study using high‐resolution esophageal manometry with impedance. Neurogastroenterology & Motility 2016, 29 PMID: 28002887, PMCID: PMC5393952, DOI: 10.1111/nmo.12998.Peer-Reviewed Original ResearchUtility of Octreotide in Advancing Enteral Feeds in Children with Chronic Intestinal Pseudo-Obstruction
Ambartsumyan L, Flores A, Nurko S, Rodriguez L. Utility of Octreotide in Advancing Enteral Feeds in Children with Chronic Intestinal Pseudo-Obstruction. Pediatric Drugs 2016, 18: 387-392. PMID: 27520652, DOI: 10.1007/s40272-016-0189-x.Peer-Reviewed Original ResearchConceptsOctreotide responseEnteral toleranceAntroduodenal manometryChronic Intestinal Pseudo-ObstructionEfficacy of octreotideIntestinal phase IIIIntestinal Pseudo-ObstructionPresence of ileostomyTPN-dependent childrenTertiary care centerTotal parenteral nutritionMethodsThe study populationLimited effective therapiesHigher median increasePseudo-ObstructionParenteral nutritionEnteral feedsHigh morbidityProspective studyResultsA totalCare centerEffective therapyChallenging disorderAllergic reactionsStudy population
2015
Effect of anesthesia on gastroesophageal reflux in children: a study using BRAVO wireless pH study measurements
Rodriguez L, Morley-Fletcher A, Souza A, Rosengaus L, Nurko S. Effect of anesthesia on gastroesophageal reflux in children: a study using BRAVO wireless pH study measurements. Neurogastroenterology & Motility 2015, 27: 1553-1558. PMID: 26264213, PMCID: PMC4624481, DOI: 10.1111/nmo.12652.Peer-Reviewed Original ResearchConceptsEffects of anesthesiaGastroesophageal refluxBravo wirelessStudy interpretationAnesthesia effectProportion of studiesRole of anesthesiaGER parametersCapsule placementAnesthesiaCutoff valueStudy durationAbstractTextSignificant increaseChildrenRefluxSignificant changesStudy measurementsDaysHoursBlock timePatientsStudyProportionHigh-resolution manometry combined with impedance measurements discriminates the cause of dysphagia in children
Rommel N, Omari TI, Selleslagh M, Kritas S, Cock C, Rosan R, Rodriguez L, Nurko S. High-resolution manometry combined with impedance measurements discriminates the cause of dysphagia in children. European Journal Of Pediatrics 2015, 174: 1629-1637. PMID: 26105773, DOI: 10.1007/s00431-015-2582-9.Peer-Reviewed Original ResearchConceptsPressure-flow analysisPressure-flow indexGastroesophageal reflux diseaseCause of dysphagiaWeak peristalsisPost-fundoplication dysphagiaHigh-resolution manometryPediatric patientsEsophageal dysfunctionDysphagia symptomsEndoscopic therapyNormal peristalsisOptimal treatmentEsophageal functionClinical practiceTrachea-esophageal fistulaDifferentiation of patientsNon-obstructive dysphagiaPressure flow parametersPediatric clinical practicePressure-flow metricsAdult patientsReflux diseaseEsophageal motilityEsophageal bolus transport
2013
Longitudinal and Radial Characteristics of Intra-Anal Pressures in Children Using 3D High-Definition Anorectal Manometry: New Observations
Ambartsumyan L, Rodriguez L, Morera C, Nurko S. Longitudinal and Radial Characteristics of Intra-Anal Pressures in Children Using 3D High-Definition Anorectal Manometry: New Observations. The American Journal Of Gastroenterology 2013, 108: 1918. PMID: 24169274, DOI: 10.1038/ajg.2013.361.Peer-Reviewed Original ResearchRelationship between postprandial metabolomics and colon motility in children with constipation
Rodriguez L, Roberts LD, LaRosa J, Heinz N, Gerszten R, Nurko S, Goldstein AM. Relationship between postprandial metabolomics and colon motility in children with constipation. Neurogastroenterology & Motility 2013, 25: 420-e299. PMID: 23421516, PMCID: PMC3877617, DOI: 10.1111/nmo.12086.Peer-Reviewed Original ResearchConceptsTreatment of constipationColonic motilityMotility indexMotility patternsNormal postprandial increasePostprandial motility patternCohort of childrenPostprandial metabolic changesSignificant metabolite changesColon manometryColon motilityConstipated childrenProspective studyStandardized mealKynurenic acidMeal challengePostprandial increasePostprandial changesMultiple time pointsConstipationLipid metabolitesPotential metabolic targetsAbstractTextSpecific metabolitesMetabolic changesSafety and Efficacy of Cyproheptadine for Treating Dyspeptic Symptoms in Children
Rodriguez L, Diaz J, Nurko S. Safety and Efficacy of Cyproheptadine for Treating Dyspeptic Symptoms in Children. The Journal Of Pediatrics 2013, 163: 261-267. PMID: 23419589, PMCID: PMC3661691, DOI: 10.1016/j.jpeds.2012.12.096.Peer-Reviewed Original ResearchConceptsEfficacy of cyproheptadineDyspeptic symptomsEarly vomitingSide effectsMultivariate analysisRetrospective open-label studyOpen-label studyUpper gastrointestinal symptomsPotent serotonin antagonistUse of cyproheptadineLack of responseLate vomitingAbdominal painGastrointestinal symptomsAntroduodenal manometryFunctional dyspepsiaNissen fundoplicationSerotonin antagonistsFirst therapyGastric emptyingFurther interventionTherapy responseVomitingCyproheptadineResponse rate
2012
Clinical Presentation, Response to Therapy, and Outcome of Gastroparesis in Children
Rodriguez L, Irani K, Jiang H, Goldstein AM. Clinical Presentation, Response to Therapy, and Outcome of Gastroparesis in Children. Journal Of Pediatric Gastroenterology And Nutrition 2012, 55: 185-190. PMID: 22228004, DOI: 10.1097/mpg.0b013e318248ed3f.Peer-Reviewed Original ResearchConceptsPediatric gastroparesisPostviral gastroparesisPromotility therapySymptom resolutionClinical featuresMitochondrial dysfunctionYounger ageOutcomes of gastroparesisMore vomitingPromotility drugsAbdominal painClinical presentationMedian timeRetrospective reviewMale sexMean ageEffective therapyGastroparesisVariable symptomatologyMultivariate analysisTherapySymptomsMonthsLonger durationOverall rateEndoscopic intrapyloric injection of botulinum toxin A in the treatment of children with gastroparesis: a retrospective, open-label study
Rodriguez L, Rosen R, Manfredi M, Nurko S. Endoscopic intrapyloric injection of botulinum toxin A in the treatment of children with gastroparesis: a retrospective, open-label study. Gastrointestinal Endoscopy 2012, 75: 302-309. PMID: 22248598, PMCID: PMC3260460, DOI: 10.1016/j.gie.2011.09.042.Peer-Reviewed Original ResearchConceptsOpen-label studyBotulinum toxin APredictive factorsToxin ASingle tertiary care centerLong-term clinical outcomesRefractory gastroparesis symptomsSymptoms of gastroparesisPlacebo-controlled trialTertiary care centerManagement of childrenSingle case reportsTreatment of childrenGastroparesis refractoryGastroparesis symptomsIntrapyloric injectionReported exacerbationsSpastic disordersClinical improvementMedian durationOlder patientsBotulinum injectionMale patientsMedical therapyRetrospective review
2010
Antegrade colonic enemas and intestinal diversion are highly effective in the management of children with intractable constipation
Christison-Lagay ER, Rodriguez L, Kurtz M, St. Pierre K, Doody DP, Goldstein AM. Antegrade colonic enemas and intestinal diversion are highly effective in the management of children with intractable constipation. Journal Of Pediatric Surgery 2010, 45: 213-219. PMID: 20105606, DOI: 10.1016/j.jpedsurg.2009.10.034.Peer-Reviewed Original ResearchConceptsAntegrade continence enemaIntractable constipationSatisfactory outcomeContinence enemaIntestinal continuityRetrospective reviewSurgical approachPredictors of successColonic manometry studiesPassage of stoolPrimary colonic resectionManagement of childrenOptimal surgical approachAntegrade colonic enemaInitial therapyAbdominal distensionIdiopathic constipationPrimary resectionColonic resectionAdditional surgeryColonic manometryMedical therapyPediatric patientsACE procedureColonic enema
2008
Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction
Irani K, Rodriguez L, Doody DP, Goldstein AM. Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction. Pediatric Surgery International 2008, 24: 779-783. PMID: 18443801, DOI: 10.1007/s00383-008-2171-3.Peer-Reviewed Original ResearchConceptsInternal anal sphincter dysfunctionAnal sphincter dysfunctionIntrasphincteric injectionSphincter dysfunctionIntractable constipationPediatric patientsBotulinum toxinIAS dysfunctionAbnormal anorectal manometryRectoanal inhibitory reflexTreatment of constipationDuration of effectChronic constipationPostoperative incontinenceRefractory constipationInhibitory reflexAnorectal manometryResting pressureRetrospective reviewBotox injectionHirschsprung's diseaseConstipationEffective treatmentPatientsDysfunction