2024
Testing in functional constipation—What's new and what works
Rodriguez L. Testing in functional constipation—What's new and what works. Alimentary Pharmacology & Therapeutics 2024, 60: s30-s41. PMID: 38940015, DOI: 10.1111/apt.17857.Peer-Reviewed Original ResearchColonic manometryFecal incontinenceConventional therapyRadiopaque markersFunctional constipationNon-retentive fecal incontinenceDiagnostic studiesFailed medical therapyLumbar spine MRIRecto-anal inhibitory reflexAnal resting pressureAbdominal X-raySpine MRIAnorectal manometryMedical therapyPaediatric constipationSurgical interventionClinical findingsInhibitory reflexEvaluate anatomySpinal abnormalitiesColonic transitMedical historyPaediatric gastroenterologistsConstipation
2023
Clinical utility of colonic low‐amplitude propagating contractions in children with functional constipation
Colliard K, Patel D, Nurko S, Rodriguez L. Clinical utility of colonic low‐amplitude propagating contractions in children with functional constipation. Neurogastroenterology & Motility 2023, 35: e14543. PMID: 37096634, DOI: 10.1111/nmo.14543.Peer-Reviewed Original ResearchConceptsFunctional constipationLogistic regressionClinical utilityPediatric functional constipationConstipation groupRetrospective reviewColonic enemaClinical significanceLAPCConstipationNeuromuscular integrityLarger studyPatientsOutcomesChildrenAssociationContractionHigher proportionHAPCsGroupRegressionIleostomyEnema
2022
Diverting Ileostomy in Children With Functional Constipation
Rodriguez L, Colliard K, Nurko S, Flores A, Buchmiller TL. Diverting Ileostomy in Children With Functional Constipation. Journal Of Pediatric Gastroenterology And Nutrition 2022, 75: 578-583. PMID: 35897140, DOI: 10.1097/mpg.0000000000003579.Peer-Reviewed Original ResearchConceptsFunctional constipationOstomy closurePediatric functional constipationInstitutional review board approvalReview board approvalEnema failureColon motilityFurther surgeryInvasive evaluationRetrospective studySurgical interventionOstomyBoard approvalUseful interventionLarger studyConstipationSuccessful responsePatientsSurgeryChildrenRole of CMDemographicsAssociationInterventionIndications
2021
Can Propofol Be Used to Assess the Presence of the Rectoanal Inhibitory Reflex During Anorectal Manometry Studies?
Arbizu RA, Amicangelo M, Rodriguez L, Nurko S. Can Propofol Be Used to Assess the Presence of the Rectoanal Inhibitory Reflex During Anorectal Manometry Studies? Journal Of Pediatric Gastroenterology And Nutrition 2021, 74: 33-37. PMID: 34478251, DOI: 10.1097/mpg.0000000000003283.Peer-Reviewed Original ResearchConceptsIntra-anal pressuresRectoanal inhibitory reflexAnorectal manometryInhibitory reflexAbsent rectoanal inhibitory reflexInternal anal sphincter relaxationNormal rectoanal inhibitory reflexAnal sphincter relaxationAnorectal manometry studyBalloon distentionIAS relaxationSpinal neuropathyIntractable constipationObstructive symptomsSphincter relaxationProspective studyAnesthesia inductionManometry studiesPatientsPropofolDisease repairLatency timeConstipationAnesthesiaReflexMelanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation
Chen JJ, Kitzia Colliard RN, Nurko S, Rodriguez L. Melanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation. Digestive Diseases And Sciences 2021, 67: 3922-3928. PMID: 34379221, DOI: 10.1007/s10620-021-07191-z.Peer-Reviewed Original ResearchConceptsPediatric functional constipationMelanosis coliFunctional constipationColonic manometryColonic motilityMarker of severityTreatment of constipationRate of surgeryColonic dysmotilityColonic biopsiesMedian agePediatric patientsManometry resultsMedication historyMethodsProspective studyPatient groupResultsA totalSurgical historyPathologic resultsConstipationPatientsCatheter positionDemographic dataSubsequent needSignificant differences
2020
Evaluation of Fecal Incontinence in Pediatric Functional Constipation
Morera C, Nurko S, Rodriguez L. Evaluation of Fecal Incontinence in Pediatric Functional Constipation. Journal Of Pediatric Gastroenterology And Nutrition 2020, 72: 361-365. PMID: 33560756, DOI: 10.1097/mpg.0000000000002978.Peer-Reviewed Original ResearchConceptsPediatric functional constipationFecal incontinenceFunctional constipationColonic manometryMedian anal resting pressureAnal resting pressureMore patientsResting pressureAbnormal studiesConventional therapyMale genderTreatment outcomesClinical dataConstipationNormal studiesTherapy responseMeal responseIncontinencePatientsMultivariate analysisMotility studiesTherapyNormal armLow responseManometryLong‐term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy
Bonilla S, Nurko S, Rodriguez L. Long‐term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy. Journal Of Pediatric Gastroenterology And Nutrition 2020, 71: 288-291. PMID: 32459741, DOI: 10.1097/mpg.0000000000002795.Peer-Reviewed Original ResearchConceptsConventional therapyLong-term usePediatric constipationFunctional constipationSide effectsTertiary care children's hospitalFrequency of BMPediatric functional constipationBowel movement frequencyLong-term followLong-term treatmentMedian doseRescue therapyMedian durationStandard therapyOsmotic laxativesRetrospective reviewPediatric populationChildren's HospitalStimulant laxativesMedian numberConstipationPatientsTreatment durationFavorable responseUtility of Colon Manometry in Guiding Therapy and Predicting Need for Surgery in Children With Defecation Disorders
Rodriguez L, Heinz N, Nurko S. Utility of Colon Manometry in Guiding Therapy and Predicting Need for Surgery in Children With Defecation Disorders. Journal Of Pediatric Gastroenterology And Nutrition 2020, 70: 232-237. PMID: 31978023, DOI: 10.1097/mpg.0000000000002504.Peer-Reviewed Original ResearchConceptsColon manometryChange of therapyGastrocolonic responseHigh response rateDefecation disordersResponse rateMedical interventionsLogistic regression analysisPresence/numberPediatric constipationFecal incontinenceSuccessful medical interventionDefecation problemsRetrospective reviewPredicting NeedPostsurgical evaluationSurgical interventionStimulant laxativesStudy indicationSurgeryTherapyFirst interventionInterventionConstipationManometry
2017
Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation
Arbizu RA, Nurko S, Heinz N, Amicangelo M, Rodriguez L. Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation. Neurogastroenterology & Motility 2017, 29 PMID: 28317231, PMCID: PMC5466533, DOI: 10.1111/nmo.13050.Peer-Reviewed Original ResearchConceptsDay 1Day 2Normal studiesAbnormal studiesProportion of patientsSame dayStudy interpretationColon manometryGastrocolonic responseRefractory constipationProspective evaluationManometry parametersMotility indexPatientsChallenge phaseAbstractTextAnesthesiaCatheterStudy parametersColonoscopyDaysConstipationHAPCsManometryStudy
2015
618 Effect of Anesthesia in Colon Motility: Prospective Study of Children With Intractable Constipation Undergoing Colon Manometry
Arbizu R, Heinz N, Amicangelo M, Nurko S, Rodriguez L. 618 Effect of Anesthesia in Colon Motility: Prospective Study of Children With Intractable Constipation Undergoing Colon Manometry. Gastroenterology 2015, 148: s-121. DOI: 10.1016/s0016-5085(15)30421-2.Peer-Reviewed Original Research
2014
Gastrointestinal motility disorders in children.
Ambartsumyan L, Rodriguez L. Gastrointestinal motility disorders in children. Gastroenterology & Hepatology 2014, 10: 16-26. PMID: 24799835, PMCID: PMC4008955.Peer-Reviewed Original ResearchGastrointestinal motility disordersGastroesophageal reflux diseaseCommon gastrointestinal motility disordersMotility disordersEsophageal achalasiaSignificant morbidityPneumatic balloon dilationPediatric patient populationNew diagnostic techniquesReflux diseaseBalloon dilationPatient populationCommon complaintClinical trialsCommon disorderSecretion blockadeDisordersConstipationGastroparesisAchalasiaMorbidityChildrenDiagnostic techniquesPoor qualityEsophagomyotomy
2013
Relationship between postprandial metabolomics and colon motility in children with constipation
Rodriguez L, Roberts LD, LaRosa J, Heinz N, Gerszten R, Nurko S, Goldstein AM. Relationship between postprandial metabolomics and colon motility in children with constipation. Neurogastroenterology & Motility 2013, 25: 420-e299. PMID: 23421516, PMCID: PMC3877617, DOI: 10.1111/nmo.12086.Peer-Reviewed Original ResearchConceptsTreatment of constipationColonic motilityMotility indexMotility patternsNormal postprandial increasePostprandial motility patternCohort of childrenPostprandial metabolic changesSignificant metabolite changesColon manometryColon motilityConstipated childrenProspective studyStandardized mealKynurenic acidMeal challengePostprandial increasePostprandial changesMultiple time pointsConstipationLipid metabolitesPotential metabolic targetsAbstractTextSpecific metabolitesMetabolic changes
2012
Internal anal sphincter relaxation associated with bisacodyl‐induced colonic high amplitude propagating contractions in children with constipation: a colo‐anal reflex?
Rodriguez L, Siddiqui A, Nurko S. Internal anal sphincter relaxation associated with bisacodyl‐induced colonic high amplitude propagating contractions in children with constipation: a colo‐anal reflex? Neurogastroenterology & Motility 2012, 24: 1023-e545. PMID: 22757618, PMCID: PMC3465462, DOI: 10.1111/j.1365-2982.2012.01965.x.Peer-Reviewed Original ResearchConceptsHigh-amplitude peristaltic contractionsInternal anal sphincter relaxationAnal sphincter relaxationIAS relaxationSphincter relaxationAnal residual pressureManometry tracingsDefecation disordersConstipated childrenAnal relaxationHepatic flexureResting pressureDistal colonPeristaltic contractionsColonAbstractTextConstipationContraction propagationReflexChildrenImportant proportionContractionMost casesPatientsBisacodyl
2008
Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction
Irani K, Rodriguez L, Doody DP, Goldstein AM. Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction. Pediatric Surgery International 2008, 24: 779-783. PMID: 18443801, DOI: 10.1007/s00383-008-2171-3.Peer-Reviewed Original ResearchConceptsInternal anal sphincter dysfunctionAnal sphincter dysfunctionIntrasphincteric injectionSphincter dysfunctionIntractable constipationPediatric patientsBotulinum toxinIAS dysfunctionAbnormal anorectal manometryRectoanal inhibitory reflexTreatment of constipationDuration of effectChronic constipationPostoperative incontinenceRefractory constipationInhibitory reflexAnorectal manometryResting pressureRetrospective reviewBotox injectionHirschsprung's diseaseConstipationEffective treatmentPatientsDysfunction
2006
Evaluation and Management of Intractable Constipation in Children
Rodriguez L, Flores A, Doody D. Evaluation and Management of Intractable Constipation in Children. Seminars In Colon And Rectal Surgery 2006, 17: 29-37. DOI: 10.1053/j.scrs.2006.02.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIntractable constipationPediatric age groupAdditional surgical interventionUse of laxativesSevere intractable constipationRefractory constipationStool softenersYounger patientsPediatric gastroenterologistsPossible surgerySurgical interventionConstipationDaily livingSmall percentageSevere formDiet managementDays of schoolGastroenterologists' officesAge groupsNormal activityChildren's qualityBehavioral modificationFrequent visitsPatientsChildren