2020
Utility of Colon Manometry in Guiding Therapy and Predicting Need for Surgery in Children With Defecation Disorders
Rodriguez L, Heinz N, Nurko S. Utility of Colon Manometry in Guiding Therapy and Predicting Need for Surgery in Children With Defecation Disorders. Journal Of Pediatric Gastroenterology And Nutrition 2020, 70: 232-237. PMID: 31978023, DOI: 10.1097/mpg.0000000000002504.Peer-Reviewed Original ResearchConceptsColon manometryChange of therapyGastrocolonic responseHigh response rateDefecation disordersResponse rateMedical interventionsLogistic regression analysisPresence/numberPediatric constipationFecal incontinenceSuccessful medical interventionDefecation problemsRetrospective reviewPredicting NeedPostsurgical evaluationSurgical interventionStimulant laxativesStudy indicationSurgeryTherapyFirst interventionInterventionConstipationManometry
2017
Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation
Arbizu RA, Nurko S, Heinz N, Amicangelo M, Rodriguez L. Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation. Neurogastroenterology & Motility 2017, 29 PMID: 28317231, PMCID: PMC5466533, DOI: 10.1111/nmo.13050.Peer-Reviewed Original ResearchConceptsDay 1Day 2Normal studiesAbnormal studiesProportion of patientsSame dayStudy interpretationColon manometryGastrocolonic responseRefractory constipationProspective evaluationManometry parametersMotility indexPatientsChallenge phaseAbstractTextAnesthesiaCatheterStudy parametersColonoscopyDaysConstipationHAPCsManometryStudy
2015
618 Effect of Anesthesia in Colon Motility: Prospective Study of Children With Intractable Constipation Undergoing Colon Manometry
Arbizu R, Heinz N, Amicangelo M, Nurko S, Rodriguez L. 618 Effect of Anesthesia in Colon Motility: Prospective Study of Children With Intractable Constipation Undergoing Colon Manometry. Gastroenterology 2015, 148: s-121. DOI: 10.1016/s0016-5085(15)30421-2.Peer-Reviewed Original Research
2013
Relationship between postprandial metabolomics and colon motility in children with constipation
Rodriguez L, Roberts LD, LaRosa J, Heinz N, Gerszten R, Nurko S, Goldstein AM. Relationship between postprandial metabolomics and colon motility in children with constipation. Neurogastroenterology & Motility 2013, 25: 420-e299. PMID: 23421516, PMCID: PMC3877617, DOI: 10.1111/nmo.12086.Peer-Reviewed Original ResearchConceptsTreatment of constipationColonic motilityMotility indexMotility patternsNormal postprandial increasePostprandial motility patternCohort of childrenPostprandial metabolic changesSignificant metabolite changesColon manometryColon motilityConstipated childrenProspective studyStandardized mealKynurenic acidMeal challengePostprandial increasePostprandial changesMultiple time pointsConstipationLipid metabolitesPotential metabolic targetsAbstractTextSpecific metabolitesMetabolic changes
2012
Factors associated with successful decrease and discontinuation of antegrade continence enemas (ACE) in children with defecation disorders: a study evaluating the effect of ACE on colon motility
Rodriguez L, Nurko S, Flores A. Factors associated with successful decrease and discontinuation of antegrade continence enemas (ACE) in children with defecation disorders: a study evaluating the effect of ACE on colon motility. Neurogastroenterology & Motility 2012, 25: 140-e81. PMID: 23035840, PMCID: PMC3546133, DOI: 10.1111/nmo.12018.Peer-Reviewed Original ResearchConceptsAntegrade continence enemaColon manometryACE decreaseContinence enemaColon motilityDefecation disordersOlder ageReview of childrenGastrocolonic responseMotility indexOnly predictorMultivariate analysisDiscontinuationAbstractTextEnemaOutcomesPatientsSignificant increaseChildrenSuccessful decreaseDisordersAgeHAPCsMotilityCM changes