2022
Comparative Effectiveness and Safety of Seizure Prophylaxis Among Adults After Acute Ischemic Stroke
Moura L, Donahue M, Yan Z, Smith L, Hsu J, Newhouse J, Schwamm L, Haneuse S, Hernandez-Diaz S, Blacker D. Comparative Effectiveness and Safety of Seizure Prophylaxis Among Adults After Acute Ischemic Stroke. Stroke 2022, 54: 527-536. PMID: 36544249, PMCID: PMC9870933, DOI: 10.1161/strokeaha.122.039946.Peer-Reviewed Original ResearchConceptsSeizure prophylaxisRisk differenceAntiseizure drugsEarly seizure prophylaxisSevere AIS patientsAcute ischemic strokePrespecified subgroup analysisHealth care factorsInverse probability weightsElectronic health recordsAIS admissionsPoststroke mortalityStroke RegistryIschemic strokeAIS patientsStroke settingsCare factorsSubgroup analysisProphylaxisMortality riskHigh riskPatientsComparative effectivenessExcess deathsTrial data
2020
Patterns of anticonvulsant use and adverse drug events in older adults
Moura L, Smith J, Yan Z, Blacker D, Schwamm L, Newhouse J, Hernandez‐Diaz S, Hsu J. Patterns of anticonvulsant use and adverse drug events in older adults. Pharmacoepidemiology And Drug Safety 2020, 30: 28-36. PMID: 33009718, PMCID: PMC7849867, DOI: 10.1002/pds.5139.Peer-Reviewed Original ResearchConceptsAdverse drug eventsElectronic health recordsIncident usersAnticonvulsant useDrug eventsMedicare beneficiariesRate of ADEsSeverity of ADEsSignificant adverse drug eventsEligible beneficiariesOlder adultsCohort of communityDuration of useRange of indicationsTraditional Medicare beneficiariesInverse probability weightsADE ratesMonotherapy usersSingle anticonvulsantAnticonvulsant therapyPain reliefCommon indicationOriginal cohortNervous systemOlder adult community
2019
Epilepsy Among Elderly Medicare Beneficiaries
Moura L, Smith J, Blacker D, Vogeli C, Schwamm L, Cole A, Hernandez-Diaz S, Hsu J. Epilepsy Among Elderly Medicare Beneficiaries. Medical Care 2019, 57: 318-324. PMID: 30762723, PMCID: PMC6417929, DOI: 10.1097/mlr.0000000000001072.Peer-Reviewed Original ResearchConceptsMedicare administrative dataEpilepsy statusMedicare beneficiariesMedicare dataEpilepsy diagnosisElectronic health record dataElderly Medicare beneficiariesHealth record dataHealth insurance claimsAdministrative dataElectronic health recordsIncident epilepsyPrevalent epilepsyDrug claimsEpilepsyDiagnostic thresholdStratified random sampleInverse probabilityHealth recordsMedicare claims can identify post-stroke epilepsy
Moura L, Smith J, Blacker D, Vogeli C, Schwamm L, Hsu J. Medicare claims can identify post-stroke epilepsy. Epilepsy Research 2019, 151: 40-47. PMID: 30780120, PMCID: PMC6640134, DOI: 10.1016/j.eplepsyres.2019.02.002.Peer-Reviewed Original ResearchConceptsElectronic health recordsAccountable care organizationsMedicare claimsCommunity-dwelling elderly individualsPost-stroke epilepsyElderly Medicare beneficiariesClaims-based algorithmPositive predictive valuePioneer Accountable Care OrganizationsDiscrete etiologyNeurologist visitOverall prevalenceMedicare patientsClaims diagnosesPSE diagnosisElderly individualsMedicare beneficiariesPatientsPredictive valueEpilepsyFuture epidemiological surveillanceEpidemiological surveillanceInverse probabilityHealth recordsDiagnosis