2019
Intravenous Tissue Plasminogen Activator in Stroke Mimics
Ali-Ahmed F, Federspiel J, Liang L, Xu H, Sevilis T, Hernandez A, Kosinski A, Prvu Bettger J, Smith E, Bhatt D, Schwamm L, Fonarow G, Peterson E, Xian Y. Intravenous Tissue Plasminogen Activator in Stroke Mimics. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005609. PMID: 31412730, PMCID: PMC6699639, DOI: 10.1161/circoutcomes.119.005609.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAdultAgedAged, 80 and overBrain IschemiaDiagnosis, DifferentialFemaleFibrinolytic AgentsHumansIntracranial HemorrhagesMaleMiddle AgedPredictive Value of TestsRegistriesRisk AssessmentRisk FactorsStrokeThrombolytic TherapyTissue Plasminogen ActivatorTreatment OutcomeUnited StatesUnnecessary ProceduresConceptsTransient ischemic attackStroke mimicsIschemic strokeIschemic attackPrior stroke/transient ischemic attackStroke/transient ischemic attackIntravenous tissue plasminogen activatorGuidelines-Stroke registrySymptomatic intracranial hemorrhageCardiovascular risk factorsHealth Stroke ScaleHospital mortality rateAcute ischemic strokeStroke-like symptomsTissue plasminogen activatorUse of tPANonstroke diagnosisThrombolysis safetyIntravenous tPAStroke ScaleComplication rateIntracranial hemorrhagePresumed strokeRisk factorsFunctional disorders
2018
Evaluation of a score for the prehospital distinction between cerebrovascular disease and stroke mimic patients
Geisler F, Ali S, Ebinger M, Kunz A, Rozanski M, Waldschmidt C, Weber J, Wendt M, Winter B, Schwamm L, Audebert H. Evaluation of a score for the prehospital distinction between cerebrovascular disease and stroke mimic patients. International Journal Of Stroke 2018, 14: 400-408. PMID: 30303808, DOI: 10.1177/1747493018806194.Peer-Reviewed Original ResearchConceptsStroke mimic patientsIndividual patient characteristicsMimic patientsCerebrovascular diseaseStroke mimicsPatient characteristicsFocal neurological deficitsCerebrovascular disease patientsCertain patient characteristicsMobile stroke unitPre-hospital settingSevere strokeArterial hypertensionNeurological deficitsStroke unitAtrial fibrillationDisease patientsSudden onsetEmergency physiciansHospital destinationPatientsDiscriminative valueFinal analysisDiseaseStroke
2016
Case 13-2016 — A 49-Year-Old Woman with Sudden Hemiplegia and Aphasia during a Transatlantic Flight
Schwamm L, Jaff M, Dyer K, Gonzalez R, Huck A. Case 13-2016 — A 49-Year-Old Woman with Sudden Hemiplegia and Aphasia during a Transatlantic Flight. New England Journal Of Medicine 2016, 374: 1671-1680. PMID: 27119240, DOI: 10.1056/nejmcpc1501151.Peer-Reviewed Original Research
2012
Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke
Hakimelahi R, Yoo A, He J, Schwamm L, Lev M, Schaefer P, González R. Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke. BMC Neurology 2012, 12: 132. PMID: 23121836, PMCID: PMC3519648, DOI: 10.1186/1471-2377-12-132.Peer-Reviewed Original ResearchConceptsDiffusion/perfusion mismatchDWI lesion volumeInternal carotid arteryLesion volumePerfusion mismatchConsecutive patientsCarotid arteryMiddle cerebral artery ischemic strokeDiffusion/perfusion MRITerminal internal carotid arteryProximal middle cerebral arteryDistal internal carotid arteryLarger mismatch volumeProximal MCA occlusionMiddle cerebral arteryDiffusion lesion volumeSame inclusion criteriaTerminal ICAArtery occlusionIschemic strokeMCA occlusionStroke onsetCerebral arteryStroke patientsPatient assessment
2009
ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes
Sims J, Gharai L, Schaefer P, Vangel M, Rosenthal E, Lev M, Schwamm L. ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes. Neurology 2009, 72: 2104-2110. PMID: 19528517, PMCID: PMC2697964, DOI: 10.1212/wnl.0b013e3181aa5329.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrainBrain InfarctionCerebral ArteriesCerebral HemorrhageCerebrovascular CirculationComputer SimulationDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedNerve Fibers, MyelinatedPredictive Value of TestsRetrospective StudiesSeverity of Illness IndexTime FactorsFalse Positive CT Angiography in Brain Death
Greer DM, Strozyk D, Schwamm LH. False Positive CT Angiography in Brain Death. Neurocritical Care 2009, 11: 272-275. PMID: 19390993, DOI: 10.1007/s12028-009-9220-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain DeathBrain EdemaCerebral AngiographyCerebrovascular CirculationCircle of WillisDiagnosis, DifferentialElectroencephalographyFalse Positive ReactionsFemaleHeart ArrestHumansTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedUltrasonography, Doppler, TranscranialConceptsCerebral circulatory arrestBrain criteriaCirculatory arrestBrain deathPositive CT angiographyCerebral blood flowSingle photon emissionTranscranial DopplerNewer testsClinical examinationTomographic angiographyConventional angiographyCT angiographyBlood flowAncillary testsEase of performanceAngiographyDetermination of deathGold standardConfirmatory testDeathPhoton emissionAcceptable testArrestPatients
2006
MRI contrast extravasation with enlarging hyperacute thrombolysis-related hemorrhage
Nguyen T, Rordorf G, Schwamm L, Smith E. MRI contrast extravasation with enlarging hyperacute thrombolysis-related hemorrhage. Neurology 2006, 66: e30. PMID: 16636225, DOI: 10.1212/01.wnl.0000208439.31635.96.Peer-Reviewed Original Research
2001
Diagnostic Value of Apparent Diffusion Coefficient Hyperintensity in Selected Patients With Acute Neurologic Deficits
Schaefer P, Gonzalez R, Hunter G, Wang B, Koroshetz W, Schwamm L. Diagnostic Value of Apparent Diffusion Coefficient Hyperintensity in Selected Patients With Acute Neurologic Deficits. Journal Of Neuroimaging 2001, 11: 369-380. PMID: 11677876, DOI: 10.1111/j.1552-6569.2001.tb00065.x.Peer-Reviewed Original ResearchConceptsAcute neurologic deficitsMagnetic resonance imagingDiffusion-weighted imagingNeurologic deficitsMRI abnormalitiesClinical syndromeMRI T2 hyperintensityVenous sinus thrombosisIschemic brain injuryEvaluation of patientsSubset of patientsConventional magnetic resonance imagingApparent diffusion coefficient (ADC) mapsDiffusion coefficient mapsHIV encephalopathyHypertensive encephalopathyNonischemic etiologyPosterior leukoencephalopathySinus thrombosisCarotid endarterectomyT2 hyperintensityNeurologic conditionsVasogenic edemaBrain injuryDiffusion magnetic resonance imaging
1997
Diffusion-weighted imaging discriminates between cytotoxic and vasogenic edema in a patient with eclampsia.
Schaefer P, Buonanno F, Gonzalez R, Schwamm L. Diffusion-weighted imaging discriminates between cytotoxic and vasogenic edema in a patient with eclampsia. Stroke 1997, 28: 1082-5. PMID: 9158653, DOI: 10.1161/01.str.28.5.1082.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain EdemaCerebral InfarctionDiagnosis, DifferentialDiffusionEclampsiaFemaleHumansHypertensionMagnetic Resonance ImagingPregnancyVascular DiseasesVasodilationConceptsT2 hyperintense signal abnormalityDiffusion-weighted imagingHyperintense signal abnormalitiesVasogenic edemaSignal abnormalitiesRoutine MRIMajority of patientsPermanent neurological impairmentReversible neurological deficitsSubcortical white matterAdjacent gray matterDifferent treatment protocolsPathophysiology of eclampsiaEcho-planar diffusion-weighted imagingEclamptic patientsIschemic encephalopathyNeurological deficitsPosterior predominancePatient groupDiffusion-weighted imagesCytotoxic edemaNeurological impairmentPremature twinsTreatment protocolEdema