2022
Development and validation of the age-associated dementia policy (AgeD-Pol) computer simulation model in the USA and Europe
Hyle E, Foote J, Shebl F, Qian Y, Reddy K, Mukerji S, Wattananimitgul N, Viswanathan A, Schwamm L, Pandya A, Freedberg K. Development and validation of the age-associated dementia policy (AgeD-Pol) computer simulation model in the USA and Europe. BMJ Open 2022, 12: e056546. PMID: 35793913, PMCID: PMC9260808, DOI: 10.1136/bmjopen-2021-056546.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesComputer SimulationDementiaEuropeFemaleHumansMalePolicyUnited StatesConceptsAge-associated dementiaKaiser Permanente Northern CaliforniaCumulative incidenceAAD incidenceInternal validationLifetime cumulative incidenceSex-stratified dataExternal validationFramingham Heart StudyCohort studyRotterdam StudyRotterdam cohortDisease burdenDisease progressionOutcome measuresHeart StudyDATA SOURCESACT cohortAdult ChangesCohort dataNatural historyCohortMortalityHealth systemIncidence
2011
Prestroke Dementia is Associated With Poor Outcomes After Reperfusion Therapy Among Elderly Stroke Patients
Busl K, Nogueira R, Yoo A, Hirsch J, Schwamm L, Rost N. Prestroke Dementia is Associated With Poor Outcomes After Reperfusion Therapy Among Elderly Stroke Patients. Journal Of Stroke And Cerebrovascular Diseases 2011, 22: 718-724. PMID: 22182760, PMCID: PMC3310930, DOI: 10.1016/j.jstrokecerebrovasdis.2011.11.005.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAged, 80 and overDementiaDisability EvaluationFemaleFibrinolytic AgentsHospicesHospital MortalityHumansInfusions, Intra-ArterialInfusions, IntravenousLogistic ModelsMaleMultivariate AnalysisOdds RatioPatient DischargeRehabilitation CentersRetrospective StudiesRisk FactorsSkilled Nursing FacilitiesStrokeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorTreatment OutcomeConceptsIntra-arterial reperfusion therapyTissue plasminogen activatorReperfusion therapyPrestroke dementiaHospital mortalityDischarge destinationPoor outcomeStroke patientsElderly acute stroke patientsMultivariate logistic regression modelAcute reperfusion therapyGuidelines-Stroke databaseSymptomatic intracranial hemorrhageHealth Stroke ScaleHospital mortality rateAcute stroke patientsPowerful independent predictorVascular risk factorsElderly stroke patientsPresence of dementiaLikelihood of deathYears of ageLogistic regression modelsStroke ScaleSecondary outcomes