2018
Evaluation of a score for the prehospital distinction between cerebrovascular disease and stroke mimic patients
Geisler F, Ali S, Ebinger M, Kunz A, Rozanski M, Waldschmidt C, Weber J, Wendt M, Winter B, Schwamm L, Audebert H. Evaluation of a score for the prehospital distinction between cerebrovascular disease and stroke mimic patients. International Journal Of Stroke 2018, 14: 400-408. PMID: 30303808, DOI: 10.1177/1747493018806194.Peer-Reviewed Original ResearchConceptsStroke mimic patientsIndividual patient characteristicsMimic patientsCerebrovascular diseaseStroke mimicsPatient characteristicsFocal neurological deficitsCerebrovascular disease patientsCertain patient characteristicsMobile stroke unitPre-hospital settingSevere strokeArterial hypertensionNeurological deficitsStroke unitAtrial fibrillationDisease patientsSudden onsetEmergency physiciansHospital destinationPatientsDiscriminative valueFinal analysisDiseaseStroke
2015
Increased Risk of Cerebrovascular Disease Among Patients With Neurofibromatosis Type 1
Terry A, Jordan J, Schwamm L, Plotkin S. Increased Risk of Cerebrovascular Disease Among Patients With Neurofibromatosis Type 1. Stroke 2015, 47: 60-65. PMID: 26645253, DOI: 10.1161/strokeaha.115.011406.Peer-Reviewed Original ResearchConceptsNeurofibromatosis type 1Ischemic strokeIntracerebral hemorrhageGeneral populationCases of NF1US Nationwide Inpatient SampleType 1Hemorrhagic stroke typesNew neurological symptomsStroke risk factorsRisk of strokeOdds of strokeTime of strokeNationwide Inpatient SampleMultivariable logistic regressionCase-control studyType of strokeYounger mean ageAdult patientsPediatric patientsHemorrhagic strokeNeurological symptomsCerebrovascular diseaseMean ageInpatient Sample
2010
LICORICE-ASSOCIATED REVERSIBLE CEREBRAL VASOCONSTRICTION WITH PRES(CME)
Chatterjee N, Domoto-Reilly K, Fecci P, Schwamm L, Singhal A. LICORICE-ASSOCIATED REVERSIBLE CEREBRAL VASOCONSTRICTION WITH PRES(CME). Neurology 2010, 75: 1939-1941. PMID: 21098410, PMCID: PMC2995386, DOI: 10.1212/wnl.0b013e3181feb299.Peer-Reviewed Original ResearchAdministration, OralBrainCerebral AngiographyCerebrovascular CirculationCerebrovascular DisordersFemaleGlycyrrhizaHeadache Disorders, PrimaryHumansHydrocortisoneHypertensionMagnetic Resonance ImagingMiddle AgedNimodipinePosterior Leukoencephalopathy SyndromeSeizuresTomography, X-Ray ComputedTreatment OutcomeVasoconstrictionVasodilator AgentsVerapamilVision Disorders
2001
Diagnostic Value of Apparent Diffusion Coefficient Hyperintensity in Selected Patients With Acute Neurologic Deficits
Schaefer P, Gonzalez R, Hunter G, Wang B, Koroshetz W, Schwamm L. Diagnostic Value of Apparent Diffusion Coefficient Hyperintensity in Selected Patients With Acute Neurologic Deficits. Journal Of Neuroimaging 2001, 11: 369-380. PMID: 11677876, DOI: 10.1111/j.1552-6569.2001.tb00065.x.Peer-Reviewed Original ResearchConceptsAcute neurologic deficitsMagnetic resonance imagingDiffusion-weighted imagingNeurologic deficitsMRI abnormalitiesClinical syndromeMRI T2 hyperintensityVenous sinus thrombosisIschemic brain injuryEvaluation of patientsSubset of patientsConventional magnetic resonance imagingApparent diffusion coefficient (ADC) mapsDiffusion coefficient mapsHIV encephalopathyHypertensive encephalopathyNonischemic etiologyPosterior leukoencephalopathySinus thrombosisCarotid endarterectomyT2 hyperintensityNeurologic conditionsVasogenic edemaBrain injuryDiffusion magnetic resonance imaging
1999
Normal diffusion-weighted MRI during stroke-like deficits
Ay H, Buonanno F, Rordorf G, Schaefer P, Schwamm L, Wu O, Gonzalez R, Yamada K, Sorensen G, Koroshetz W. Normal diffusion-weighted MRI during stroke-like deficits. Neurology 1999, 52: 1784-1792. PMID: 10371524, DOI: 10.1212/wnl.52.9.1784.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrainCerebrovascular DisordersFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedConceptsDiffusion-weighted MRICerebral ischemic eventsDWI abnormalitiesStroke mimicsIschemic eventsAcute ischemic strokeIschemic brain injuryTransient global amnesiaIschemic causePathophysiologic diagnosisLacunar syndromeNonischemic causesIschemic strokeLacunar infarctionNeurologic deficitsBrain ischemiaConsecutive patientsSuch patientsRadiologic dataFinal diagnosisBrain injuryCortical syndromesFunctional disordersEarly diagnosisGlobal amnesiaDiffusion-weighted MR Imaging: Diagnostic Accuracy in Patients Imaged within 6 Hours of Stroke Symptom Onset
González R, Schaefer P, Buonanno F, Schwamm L, Budzik R, Rordorf G, Wang B, Sorensen A, Koroshetz W. Diffusion-weighted MR Imaging: Diagnostic Accuracy in Patients Imaged within 6 Hours of Stroke Symptom Onset. Radiology 1999, 210: 155-62. PMID: 9885601, DOI: 10.1148/radiology.210.1.r99ja02155.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrainCerebrovascular DisordersFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSensitivity and SpecificityTime FactorsTomography, X-Ray ComputedConceptsFinal clinical diagnosisDiffusion-weighted imagesDiffusion-weighted MR imagingDiffusion-weighted imagingConventional MR imagingMR imagingSymptom onsetBlinded reviewClinical diagnosisDiagnostic accuracyStroke symptom onsetDiffusion-weighted magnetic resonance imagingMagnetic resonance imagingT2-weighted MR imagingAcute strokeStroke symptomsFinal diagnosisTomographic scanStrokelike symptomsPatientsPatient recordsResonance imagingStrokeDiagnosisCT
1998
Time Course of Lesion Development in Patients With Acute Stroke
Schwamm L, Koroshetz W, Sorensen A, Wang B, Copen W, Budzik R, Rordorf G, Buonanno F, Schaefer P, Gonzalez R. Time Course of Lesion Development in Patients With Acute Stroke. Stroke 1998, 29: 2268-2276. PMID: 9804633, DOI: 10.1161/01.str.29.11.2268.Peer-Reviewed Original ResearchConceptsApparent diffusion coefficient ratioDWI lesion volumeInitial DWI lesion volumeAcute ischemic strokeT2 lesion volumeLesion volumeNeurological outcomeIschemic strokeDiffusion-weighted imaging (DWI) lesion volumeHealth Stroke Scale scoreFinal lesion volumeImaging Lesion VolumeMaximum lesion volumePatients' neurological outcomeProgressive ischemic injurySecond scanStroke Scale scoreAcute stroke patientsSecondary pathophysiological processesAcute strokeStroke onsetSymptom onsetNeurological examinationInitial imagingIschemic injuryIncreased plasma levels of lipid hydroperoxides in patients with ischemic stroke
Polidori M, Frei B, Cherubini A, Nelles G, Rordorf G, Keaney J, Schwamm L, Mecocci P, Koroshetz W, Beal M. Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke. Free Radical Biology And Medicine 1998, 25: 561-567. PMID: 9741593, DOI: 10.1016/s0891-5849(98)00085-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedAscorbic AcidBrain IschemiaCerebrovascular DisordersCholesterol EstersFemaleHumansLipid PeroxidesMagnetic Resonance ImagingMaleTomography, X-Ray ComputedConceptsIschemic brain injuryCerebral syndromeCortical strokePlasma levelsBrain injuryOxidative stressGlasgow Coma ScaleNIH Stroke ScaleLipid hydroperoxidesStroke ScaleIschemic strokeComa ScaleLacunar infarctsStroke volumeMRI scansPatientsTherapeutic interventionsDay 5Significant negative correlationSignificant positive correlationSyndromeStrokeAscorbic acid concentrationInjuryPositive correlationClinically occult pelvic-vein thrombosis in cryptogenic stroke
Cramer S, Rordorf G, Kaufman J, Buonanno F, Koroshetz W, Schwamm L. Clinically occult pelvic-vein thrombosis in cryptogenic stroke. The Lancet 1998, 351: 1927-1928. PMID: 9654263, DOI: 10.1016/s0140-6736(05)78611-6.Peer-Reviewed Original ResearchRegional Ischemia and Ischemic Injury in Patients With Acute Middle Cerebral Artery Stroke as Defined by Early Diffusion-Weighted and Perfusion-Weighted MRI
Rordorf G, Koroshetz W, Copen W, Cramer S, Schaefer P, Budzik R, Schwamm L, Buonanno F, Sorensen A, Gonzalez G. Regional Ischemia and Ischemic Injury in Patients With Acute Middle Cerebral Artery Stroke as Defined by Early Diffusion-Weighted and Perfusion-Weighted MRI. Stroke 1998, 29: 939-943. PMID: 9596239, DOI: 10.1161/01.str.29.5.939.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAgedAged, 80 and overArterial Occlusive DiseasesBrain IschemiaCerebral ArteriesCerebral InfarctionCerebrovascular CirculationCerebrovascular DisordersDiffusionFemaleHumansMagnetic Resonance AngiographyMagnetic Resonance ImagingMaleMiddle AgedPerfusionReperfusion InjuryConceptsPerfusion-weighted imagingMiddle cerebral artery strokeDiffusion-weighted imagingCerebral blood volumeMCA strokeArtery strokeMR angiographyCBV abnormalityRegional ischemiaAcute middle cerebral artery strokeInitial diffusion-weighted imagingAcute stroke syndromeDistal branch occlusionDWI lesion volumeInitial DWI lesionMCA stem occlusionGroup 2 patientsMRI techniquesFinal infarct sizeFinal infarct volumeHours of onsetIntravenous contrast bolusAbnormal tissue perfusionProgression of infarctionPerfusion-Weighted MRIAssessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results.
Hunter G, Hamberg L, Ponzo J, Huang-Hellinger F, Morris P, Rabinov J, Farkas J, Lev M, Schaefer P, Ogilvy C, Schwamm L, Buonanno F, Koroshetz W, Wolf G, González R. Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results. American Journal Of Neuroradiology 1998, 19: 29-37. PMID: 9432154, PMCID: PMC8337333.Peer-Reviewed Original ResearchConceptsHyperacute strokeFunctional CTIschemic changesEarly clinical resultsCerebral blood volumeContrast-enhanced scansHelical CT techniqueOcclusion of vesselsHyperacute groupCerebral perfusionPBV mapsArterial anatomyPatient populationBrain stemClinical resultsCT angiogramContrast administrationRegional perfusionCT angiographyBlood volumePatientsPBV valuesWhite matterGray matterClinical feasibility
1997
Pharmacological elevation of blood pressure in acute stroke. Clinical effects and safety.
Rordorf G, Cramer S, Efird J, Schwamm L, Buonanno F, Koroshetz W. Pharmacological elevation of blood pressure in acute stroke. Clinical effects and safety. Stroke 1997, 28: 2133-8. PMID: 9368553, DOI: 10.1161/01.str.28.11.2133.Peer-Reviewed Original ResearchConceptsBlood pressure thresholdAcute strokeBlood pressureInduced hypertensionCerebral arterySystolic blood pressure thresholdNeurological intensive care unitPhenylephrine-Induced HypertensionAcute cerebral ischemiaSubset of patientsIntensive care unitPressure thresholdCardiac morbidityIschemic deficitsIschemic symptomsPressor agentsBaseline characteristicsIschemic strokeNeurological deficitsCerebral ischemiaCerebral perfusionBrain edemaCare unitClinical effectsIntracerebral hemorrhage