2020
Cerebral Small Vessel Diseases and Sleep Related Strokes
Lauer A, Ay H, Bianchi M, Charidimou A, Boulouis G, Ayres A, Vashkevich A, Schwab K, Singhal A, Viswanathan A, Rost N, Goldstein J, Rosand J, Schwamm L, Greenberg S, Gurol M. Cerebral Small Vessel Diseases and Sleep Related Strokes. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 104606. PMID: 31937490, DOI: 10.1016/j.jstrokecerebrovasdis.2019.104606.Peer-Reviewed Original ResearchConceptsSmall vessel diseaseCerebral small vessel diseaseSmall artery occlusionIntracerebral hemorrhageIschemic strokeHemorrhagic strokeICH patientsVessel diseasePresence of SVDCerebral amyloid angiopathyLobar intracerebral hemorrhageICH cohortArtery occlusionSymptom onsetAmyloid angiopathyHemodynamic changesIS cohortRisk factorsStroke systemsCausative ClassificationStrokePatientsCohortDeep locationDisease
2017
Multiparametric Magnetic Resonance Imaging for Prediction of Parenchymal Hemorrhage in Acute Ischemic Stroke After Reperfusion Therapy
Nael K, Knitter J, Jahan R, Gornbein J, Ajani Z, Feng L, Meyer B, Schwamm L, Yoo A, Marshall R, Meyers P, Yavagal D, Wintermark M, Liebeskind D, Guzy J, Starkman S, Saver J, Kidwell C. Multiparametric Magnetic Resonance Imaging for Prediction of Parenchymal Hemorrhage in Acute Ischemic Stroke After Reperfusion Therapy. Stroke 2017, 48: 664-670. PMID: 28138001, PMCID: PMC5325250, DOI: 10.1161/strokeaha.116.014343.Peer-Reviewed Original ResearchConceptsCerebral blood volumeAcute ischemic strokeParenchymal hemorrhageReperfusion therapyIschemic strokeReceiver-operating characteristic curve analysisApparent diffusion coefficientMultiparametric magnetic resonance imagingPretreatment magnetic resonanceMagnetic resonance perfusionValues of CBVCharacteristic curve analysisApparent diffusion coefficient (ADC) valuesMagnetic resonance imagingIndependent predictorsIschemic coreRisk stratificationUnivariate analysisClinical trialsMicrovascular permeabilityBlood volumeInfarction corePatientsResonance imagingDiagnostic accuracy
2016
Chapter 16 Imaging acute ischemic stroke
González R, Schwamm L. Chapter 16 Imaging acute ischemic stroke. Handbook Of Clinical Neurology 2016, 135: 293-315. PMID: 27432672, DOI: 10.1016/b978-0-444-53485-9.00016-7.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeIschemic strokeCurrent evidence-based approachesSevere stroke syndromesIschemic stroke patientsPresence of hemorrhageMassachusetts General HospitalEvidence-based approachStroke syndromeAcute strokeAnterior circulationMajor strokeMore patientsArterial occlusionStroke patientsBrain parenchymaGeneral HospitalStroke typeCommon causeClinical valueComputed tomographyModern neuroimagingMagnetic resonance imaging methodLarge arteriesStroke evolution
2015
In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core?
Copen W, Morais L, Wu O, Schwamm L, Schaefer P, González R, Yoo A. In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core? PLOS ONE 2015, 10: e0133566. PMID: 26193486, PMCID: PMC4508041, DOI: 10.1371/journal.pone.0133566.Peer-Reviewed Original ResearchConceptsComputed tomography perfusion imagingDiffusion-weighted magnetic resonance imagingCerebral blood volumeInfarct volumeSensitivity/specificityCBV mapsDWI lesionsIschemic coreCore lesionsDWI-positive patientsRegional cerebral blood volumeAcute ischemic strokeFinal infarct volumeTreatment of patientsTomography perfusion imagingPresence of infarctionMagnetic resonance imagingDiffusion-weighted imagingAcute strokeIschemic strokeSymptom onsetLesion volumeIndividual patientsInter-rater agreementPatients
2014
Exposing Hidden Truncation-Related Errors in Acute Stroke Perfusion Imaging
Copen W, Deipolyi A, Schaefer P, Schwamm L, González R, Wu O. Exposing Hidden Truncation-Related Errors in Acute Stroke Perfusion Imaging. American Journal Of Neuroradiology 2014, 36: 638-645. PMID: 25500309, PMCID: PMC7964314, DOI: 10.3174/ajnr.a4186.Peer-Reviewed Original ResearchConceptsPerfusion scanVolume of lesionsScan durationSymptom onsetAcute infarctsHemodynamic measurementsLesion reversalClinical trialsLesion volumePatient managementPerfusion MRPerfusion imagingInjected contrast agentPerfusion imagesPatient CTLesionsDurationMTTCTLong scan durationScansContrast agentsShort scan durationTmaxPerfusion estimatesTime and Diffusion Lesion Size in Major Anterior Circulation Ischemic Strokes
Hakimelahi R, Vachha B, Copen W, Papini G, He J, Higazi M, Lev M, Schaefer P, Yoo A, Schwamm L, González R. Time and Diffusion Lesion Size in Major Anterior Circulation Ischemic Strokes. Stroke 2014, 45: 2936-2941. PMID: 25190444, DOI: 10.1161/strokeaha.114.005644.Peer-Reviewed Original ResearchConceptsAnterior circulation ischemic strokeMiddle cerebral artery occlusionDiffusion-weighted imagingCerebral artery occlusionStroke onsetIschemic strokeInfarct sizeDWI lesionsInfarct volumeArtery occlusionIntravenous tissue-type plasminogen activatorProximal middle cerebral arteryDistal internal carotid arteryAcute infarct volumeDWI lesion volumeMajority of patientsMiddle cerebral arteryInternal carotid arteryAcute infarct sizeSame inclusion criteriaTraditional time windowTissue-type plasminogen activatorCerebral perfusionConsecutive patientsInfarct growthSeverity of leukoaraiosis, leptomeningeal collaterals, and clinical outcomes after intra-arterial therapy in patients with acute ischemic stroke
Giurgiutiu D, Yoo A, Fitzpatrick K, Chaudhry Z, Leslie-Mazwi T, Schwamm L, Rost N. Severity of leukoaraiosis, leptomeningeal collaterals, and clinical outcomes after intra-arterial therapy in patients with acute ischemic stroke. Journal Of NeuroInterventional Surgery 2014, 7: 326. PMID: 24721756, DOI: 10.1136/neurintsurg-2013-011083.Peer-Reviewed Original ResearchConceptsIntra-arterial therapyProximal artery occlusionAcute ischemic strokeSeverity of leukoaraiosisGood functional outcomeLA volumeCollateral gradeRecanalization statusArtery occlusionIschemic strokeFunctional outcomeIntravenous tissue plasminogen activator useHealth Stroke Scale scoreLarge cerebral artery occlusionPoor post-stroke outcomesIschemic white matter lesionsTissue plasminogen activator useGood collateral gradesGreater LA volumeGuidelines-Stroke databasePoor collateral gradeStroke Scale scoreSymptomatic intracranial hemorrhageCerebral artery occlusionCerebral small vessels
2013
Neuraxial Anesthesia in Parturients with Intracranial Pathology
Leffert LR, Schwamm LH. Neuraxial Anesthesia in Parturients with Intracranial Pathology. Anesthesiology 2013, 119: 703-718. PMID: 23584382, DOI: 10.1097/aln.0b013e31829374c2.Peer-Reviewed Original Research
2012
M. D. Hammer et al.
Hammer M, Schwamm L, Starkman S, Schellinger P, Jovin T, Nogueira R, Burgin W, Sen S, Diener H, Watson T, Michel P, Shuaib A, Dillon W, Liebeskind D. M. D. Hammer et al. International Journal Of Stroke 2012, 7: 655-661. PMID: 22264202, PMCID: PMC4157918, DOI: 10.1111/j.1747-4949.2011.00719.x.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsSymptom onsetPartial aortic occlusionStroke patientsAortic occlusionIntracranial hemorrhageEight hoursInternational academic medical centersAsymptomatic intracranial hemorrhageLower baseline NIHSSSymptomatic intracranial hemorrhageFavorable neurological outcomeHealth Stroke ScalePerfusion-diffusion mismatchSingle-arm trialAcademic medical centerMagnetic resonance imagingBaseline NIHSSNeurological outcomeParenchymal hematomaStroke ScaleAdverse eventsSecondary outcomesStroke severityAcute treatment
2010
LICORICE-ASSOCIATED REVERSIBLE CEREBRAL VASOCONSTRICTION WITH PRES(CME)
Chatterjee N, Domoto-Reilly K, Fecci P, Schwamm L, Singhal A. LICORICE-ASSOCIATED REVERSIBLE CEREBRAL VASOCONSTRICTION WITH PRES(CME). Neurology 2010, 75: 1939-1941. PMID: 21098410, PMCID: PMC2995386, DOI: 10.1212/wnl.0b013e3181feb299.Peer-Reviewed Original ResearchAdministration, OralBrainCerebral AngiographyCerebrovascular CirculationCerebrovascular DisordersFemaleGlycyrrhizaHeadache Disorders, PrimaryHumansHydrocortisoneHypertensionMagnetic Resonance ImagingMiddle AgedNimodipinePosterior Leukoencephalopathy SyndromeSeizuresTomography, X-Ray ComputedTreatment OutcomeVasoconstrictionVasodilator AgentsVerapamilVision Disorders
2009
ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes
Sims J, Gharai L, Schaefer P, Vangel M, Rosenthal E, Lev M, Schwamm L. ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes. Neurology 2009, 72: 2104-2110. PMID: 19528517, PMCID: PMC2697964, DOI: 10.1212/wnl.0b013e3181aa5329.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrainBrain InfarctionCerebral ArteriesCerebral HemorrhageCerebrovascular CirculationComputer SimulationDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedNerve Fibers, MyelinatedPredictive Value of TestsRetrospective StudiesSeverity of Illness IndexTime FactorsFalse Positive CT Angiography in Brain Death
Greer DM, Strozyk D, Schwamm LH. False Positive CT Angiography in Brain Death. Neurocritical Care 2009, 11: 272-275. PMID: 19390993, DOI: 10.1007/s12028-009-9220-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain DeathBrain EdemaCerebral AngiographyCerebrovascular CirculationCircle of WillisDiagnosis, DifferentialElectroencephalographyFalse Positive ReactionsFemaleHeart ArrestHumansTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedUltrasonography, Doppler, TranscranialConceptsCerebral circulatory arrestBrain criteriaCirculatory arrestBrain deathPositive CT angiographyCerebral blood flowSingle photon emissionTranscranial DopplerNewer testsClinical examinationTomographic angiographyConventional angiographyCT angiographyBlood flowAncillary testsEase of performanceAngiographyDetermination of deathGold standardConfirmatory testDeathPhoton emissionAcceptable testArrestPatients
2008
Quantitative Assessment of Core/Penumbra Mismatch in Acute Stroke
Schaefer P, Barak E, Kamalian S, Gharai L, Schwamm L, Gonzalez R, Lev M. Quantitative Assessment of Core/Penumbra Mismatch in Acute Stroke. Stroke 2008, 39: 2986-2992. PMID: 18723425, DOI: 10.1161/strokeaha.107.513358.Peer-Reviewed Original ResearchConceptsCT perfusionPatient selectionInfarct coreAcute middle cerebral artery strokeMiddle cerebral artery strokePreferred imaging methodStroke clinical trialsAcute strokeArtery strokeStroke trialsTrial enrollmentClinical trialsLesion volumeMR perfusionIschemic regionBlood volumeTime abnormalitiesVolume thresholdLesion sizeQuantitative CTPerfusionAdvanced MRCT coverageLesionsMR diffusion
2006
First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy.
Schaefer P, Roccatagliata L, Ledezma C, Hoh B, Schwamm L, Koroshetz W, Gonzalez R, Lev M. First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy. American Journal Of Neuroradiology 2006, 27: 20-5. PMID: 16418350, PMCID: PMC7976067.Peer-Reviewed Original ResearchConceptsCerebral blood volumeAcute stroke patientsCT perfusionStroke patientsCBF ratioGray matterWhite matterAbsolute cerebral blood volumeCBV ratioIntra-arterial therapyIschemic brain tissueQuantitative CT perfusionDynamic CT perfusionIA therapyRecanalization therapyStroke onsetSalvageable penumbraInfarct coreIschemic tissueUninvolved regionsIschemic regionBlood volumeCBF valuesPatientsBrain tissue
2003
Effects of tracer arrival time on flow estimates in MR perfusion‐weighted imaging
Wu O, Østergaard L, Koroshetz W, Schwamm L, O'Donnell J, Schaefer P, Rosen B, Weisskoff R, Sorensen A. Effects of tracer arrival time on flow estimates in MR perfusion‐weighted imaging. Magnetic Resonance In Medicine 2003, 50: 856-864. PMID: 14523973, DOI: 10.1002/mrm.10610.Peer-Reviewed Original ResearchAgedBrainBrain IschemiaCerebrovascular CirculationContrast MediaFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedTime FactorsWhole-Brain CT Perfusion Measurement of Perfused Cerebral Blood Volume in Acute Ischemic Stroke: Probability Curve for Regional Infarction
Hunter G, Silvennoinen H, Hamberg L, Koroshetz W, Buonanno F, Schwamm L, Rordorf G, Gonzalez R. Whole-Brain CT Perfusion Measurement of Perfused Cerebral Blood Volume in Acute Ischemic Stroke: Probability Curve for Regional Infarction. Radiology 2003, 227: 725-30. PMID: 12728181, DOI: 10.1148/radiol.2273012169.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeCerebral blood volumeIschemic strokeBlood volumeMajor arterial occlusionLikelihood of infarctionLogistic regression analysisPositive predictive valueCT perfusion measurementsAcute strokeCerebral infarctionArterial occlusionIntracranial hemorrhagePerfusion scanCore infarctionPCBVInfarctionPositive followProbability of survivalRegional infarctionPredictive valuePatientsStrokePerfusion measurementsRegression analysis
2002
CT or MRI for Imaging Patients with Acute Stroke: Visualization of “Tissue at Risk”?
Lev M, Koroshetz W, Schwamm L, Gonzalez R. CT or MRI for Imaging Patients with Acute Stroke: Visualization of “Tissue at Risk”? Stroke 2002, 33: 2736-2737. PMID: 12468762, DOI: 10.1161/01.str.0000041999.64363.b2.Peer-Reviewed Original ResearchAnatomy of Stroke, Part II
Caviness V, Makris N, Montinaro E, Sahin N, Bates J, Schwamm L, Caplan D, Kennedy D. Anatomy of Stroke, Part II. Stroke 2002, 33: 2557-2564. PMID: 12411642, DOI: 10.1161/01.str.0000036084.82955.c7.Peer-Reviewed Original ResearchAnatomy of Stroke, Part I
Caviness V, Makris N, Montinaro E, Sahin N, Bates J, Schwamm L, Caplan D, Kennedy D. Anatomy of Stroke, Part I. Stroke 2002, 33: 2549-2556. PMID: 12411641, DOI: 10.1161/01.str.0000036083.90045.08.Peer-Reviewed Original ResearchConceptsMCA territoryVolumetric analysisDistribution of infarctsTopography of infarctionTreatment of strokePerfusion-weighted imagingCorrelation of outcomesEmbolic strokeAcute eventClinical correlatesUnderlying pathophysiologyVascular territoriesLesion volumeStroke lesionsClinical diagnosisStrokeTherapeutic agentsMRINeuroanatomic structuresInfarctsTopographic patternsInvolvementPotential benefitsPerfusion compartmentsInfarctionPredicting cerebral ischemic infarct volume with diffusion and perfusion MR imaging.
Schaefer P, Hunter G, He J, Hamberg L, Sorensen A, Schwamm L, Koroshetz W, Gonzalez R. Predicting cerebral ischemic infarct volume with diffusion and perfusion MR imaging. American Journal Of Neuroradiology 2002, 23: 1785-94. PMID: 12427640, PMCID: PMC8185825.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBlood Flow VelocityBrain IschemiaCerebral InfarctionCerebrovascular CirculationDiffusion Magnetic Resonance ImagingFalse Positive ReactionsFemaleFollow-Up StudiesHumansIschemic Attack, TransientMagnetic Resonance AngiographyMaleMiddle AgedObserver VariationPredictive Value of TestsSensitivity and SpecificityTime FactorsConceptsCerebral blood flowCerebral blood volumeFinal infarct volumeInfarct volumeDW imagingLesion growthAcute ischemic stroke symptomsHemodynamic imagesAcute ischemic infarctionIschemic infarct volumeInitial clinical assessmentFinal discharge diagnosisFinal infarct sizeHours of onsetIschemic stroke symptomsPerfusion MR imagingPerfusion-weighted imagesAcute strokeIschemic infarctionStroke symptomsAcute infarctionAcute lesionsDischarge diagnosisInfarct sizeAltered perfusion