2023
Antithrombotic and Statin Prescription After Intracerebral Hemorrhage in the Get With The Guidelines-Stroke Registry
Murthy S, Zhang C, Shah S, Schwamm L, Fonarow G, Smith E, Bhatt D, Ziai W, Kamel H, Sheth K. Antithrombotic and Statin Prescription After Intracerebral Hemorrhage in the Get With The Guidelines-Stroke Registry. Stroke 2023, 54: 2972-2980. PMID: 37942641, PMCID: PMC10842167, DOI: 10.1161/strokeaha.123.043194.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsAtrial FibrillationCerebral HemorrhageCross-Sectional StudiesFibrinolytic AgentsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLipidsMaleRegistriesRisk FactorsStrokeConceptsIschemic vascular diseaseProportion of patientsGuidelines-Stroke registryLipid-lowering therapyIntracerebral hemorrhageVascular diseaseStatin therapyAnticoagulation therapyCardiovascular eventsAtrial fibrillationFuture major cardiovascular eventsLower admission National InstitutesPrevious lipid-lowering therapyAdmission National InstitutesFavorable discharge outcomeIschemic cardiovascular eventsHealth Stroke ScaleMajor cardiovascular eventsLipid-lowering medicationsCross-sectional studyMultiple logistic regressionLogistic regression analysisAntiplatelet medicationsAntiplatelet therapyStatin medication
2019
Comparison of Clinical Care and In-Hospital Outcomes of Asian American and White Patients With Acute Ischemic Stroke
Song S, Liang L, Fonarow G, Smith E, Bhatt D, Matsouaka R, Xian Y, Schwamm L, Saver J. Comparison of Clinical Care and In-Hospital Outcomes of Asian American and White Patients With Acute Ischemic Stroke. JAMA Neurology 2019, 76: 430-439. PMID: 30667466, PMCID: PMC6459126, DOI: 10.1001/jamaneurol.2018.4410.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAsianBrain IschemiaFemaleFibrinolytic AgentsHealthcare DisparitiesHospital MortalityHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIntracranial HemorrhagesLogistic ModelsMaleMiddle AgedMultivariate AnalysisPatient DischargeQuality of Health CareRetrospective StudiesSeverity of Illness IndexStrokeStroke RehabilitationThrombolytic TherapyTime-to-TreatmentTissue Plasminogen ActivatorTreatment OutcomeUnited StatesWhite PeopleConceptsAcute ischemic strokeAsian American patientsIschemic strokeWhite patientsAmerican patientsClinical outcomesHospital mortalityStroke severityAmerican Heart Association/American Stroke AssociationIntravenous tissue plasminogen activator administrationTissue plasminogen activator administrationMultivariable logistic regression modelGreater stroke severityGuidelines-Stroke programGWTG-Stroke hospitalsIntensive statin therapyOverall stroke incidenceIn-Hospital OutcomesSevere ischemic strokeWorse functional outcomeAmerican Stroke AssociationQuality improvement registryLogistic regression modelsRace/ethnicityStatin therapy
2015
Clinical Effectiveness of Statin Therapy After Ischemic Stroke: Primary Results From the Statin Therapeutic Area of the Patient‐Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study
O'Brien E, Greiner M, Xian Y, Fonarow G, Olson D, Schwamm L, Bhatt D, Smith E, Maisch L, Hannah D, Lindholm B, Peterson E, Pencina M, Hernandez A. Clinical Effectiveness of Statin Therapy After Ischemic Stroke: Primary Results From the Statin Therapeutic Area of the Patient‐Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study. Circulation 2015, 132: 1404-1413. PMID: 26246175, DOI: 10.1161/circulationaha.115.016183.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaCardiovascular DiseasesDose-Response Relationship, DrugFemaleFollow-Up StudiesHospitalizationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMedicaidMedical RecordsMedicarePatient DischargePatient Outcome AssessmentPatient ReadmissionRecurrenceRegistriesTreatment OutcomeUnited StatesConceptsMajor adverse cardiovascular eventsAdverse cardiovascular eventsStatin therapyTime of admissionCardiovascular eventsIschemic strokePatient prefersCause mortalityHemorrhagic strokeOlder ischemic stroke patientsGuidelines-Stroke registryHigh-intensity doseIschemic stroke patientsModerate-intensity statinsPatient-centered outcomesReal-world effectivenessYears of ageOutcomes Research InstituteEffectiveness researchCoprimary outcomesCardiovascular readmissionCause readmissionSecondary outcomesStroke patientsClinical effectivenessPatient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research: Implementing the patient-driven research paradigm to aid decision making in stroke care
Xian Y, O’Brien E, Fonarow G, Olson D, Schwamm L, Hannah D, Lindholm B, Maisch L, Lytle B, Greiner M, Wu J, Peterson E, Pencina M, Hernandez A. Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research: Implementing the patient-driven research paradigm to aid decision making in stroke care. American Heart Journal 2015, 170: 36-45.e11. PMID: 26093862, DOI: 10.1016/j.ahj.2015.04.008.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overAnticoagulantsAntidepressive AgentsCohort StudiesDecision MakingDepressionFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPatient Care PlanningPatient Outcome AssessmentPatient PreferencePatient SatisfactionProspective StudiesQuality of LifeRetrospective StudiesSecondary PreventionStrokeTreatment OutcomeConceptsComparative effectiveness researchPatient prefersStroke careStroke patientsTreatment optionsEffectiveness researchMajor adverse cardiovascular eventsAdverse cardiovascular eventsIndividual patient preferencesHealth care providersOutcomes Research InstitutePatient-centered comparative effectiveness researchOutcomes research studiesHealth care communityGuidelines-StrokeCardiovascular eventsOral anticoagulantsPatient-centered outcomes research studiesStatin therapyPatient characteristicsPrimary outcomeClinical effectivenessComparative safetyPatient preferencesClinical trials
2010
Patterns and Predictors of Discharge Statin Prescription Among Hospitalized Patients With Intracerebral Hemorrhage
Ovbiagele B, Schwamm L, Smith E, Hernandez A, Olson D, Pan W, Fonarow G, Saver J. Patterns and Predictors of Discharge Statin Prescription Among Hospitalized Patients With Intracerebral Hemorrhage. Stroke 2010, 41: 2271-2277. PMID: 20724709, DOI: 10.1161/strokeaha.110.593228.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCerebral HemorrhageDatabases, FactualDrug PrescriptionsFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedOdds RatioPatient DischargePractice Patterns, Physicians'Sex FactorsConceptsDischarge statin prescriptionStatin prescriptionIntracerebral hemorrhageStatin useStatin treatmentPrior stroke/transient ischemic attackStroke/transient ischemic attackCholesterol Levels (SPARCL) trialStatin treatment armsLogistic multivariable regression modelsTransient ischemic attackHemorrhagic stroke riskHigher future riskMultivariable regression modelsGuidelines-StrokeIschemic attackEligible patientsStroke preventionIschemic eventsStroke riskHospitalized patientsHemorrhagic strokeTreatment armsMean ageFemale sexRecent Nationwide Trends in Discharge Statin Treatment of Hospitalized Patients With Stroke
Ovbiagele B, Schwamm L, Smith E, Hernandez A, Olson D, Pan W, Fonarow G, Saver J. Recent Nationwide Trends in Discharge Statin Treatment of Hospitalized Patients With Stroke. Stroke 2010, 41: 1508-1513. PMID: 20508182, DOI: 10.1161/strokeaha.109.573618.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCohort StudiesFemaleHospitalizationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPatient DischargeStrokeTime FactorsTreatment OutcomeUnited StatesConceptsTransient ischemic attackDischarge statin prescriptionIschemic attackStatin treatmentStatin useStatin prescriptionRecent nationwide trendsNationwide trendsCholesterol Levels (SPARCL) trialEligible patientsGuidelines-StrokeStroke preventionAcute strokeIschemic strokeVascular riskHospitalized patientsAtherosclerotic strokeFemale sexNonsignificant increasePatientsClinical practiceStrokeStudy periodAggressive reductionTreatment
2009
Frequency and Determinants of Lipid Testing in Ischemic Stroke and Transient Ischemic Attack
Smith E, Pan W, Olson D, Reeves M, Ovbiagele B, Peterson E, Fonarow G, Schwamm L. Frequency and Determinants of Lipid Testing in Ischemic Stroke and Transient Ischemic Attack. Stroke 2009, 41: 232-238. PMID: 20035071, DOI: 10.1161/strokeaha.109.567693.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic attackLDL measurementIschemic strokeLipid testingLarger quality improvement programmesLow-density lipoprotein testingTransient ischemic attack admissionsAdditional calendar yearConsecutive ischemic strokeGuidelines-Stroke hospitalsNationwide stroke registryLipid-lowering therapyHistory of strokeQuality Improvement ProgramLogistic regression modelsStroke RegistryHospitalized patientsLipoprotein testingAtrial fibrillationLDL levelsClinical managementHospital characteristicsNational guidelinesPatients
2008
Update to the AHA/ASA Recommendations for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack
Adams R, Albers G, Alberts M, Benavente O, Furie K, Goldstein L, Gorelick P, Halperin J, Harbaugh R, Johnston S, Katzan I, Kelly-Hayes M, Kenton E, Marks M, Sacco R, Schwamm L. Update to the AHA/ASA Recommendations for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack. Stroke 2008, 39: 1647-1652. PMID: 18322260, PMCID: PMC4198335, DOI: 10.1161/strokeaha.107.189063.Peer-Reviewed Original ResearchMeSH KeywordsAspirinBrain IschemiaClinical Trials as TopicClopidogrelDipyridamoleDrug CombinationsDrug Therapy, CombinationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemiasIschemic Attack, TransientPlatelet Aggregation InhibitorsSecondary PreventionStrokeTiclopidine