2017
Clinical Imaging Factors Associated With Infarct Progression in Patients With Ischemic Stroke During Transfer for Mechanical Thrombectomy
Boulouis G, Lauer A, Siddiqui A, Charidimou A, Regenhardt R, Viswanathan A, Rost N, Leslie-Mazwi T, Schwamm L. Clinical Imaging Factors Associated With Infarct Progression in Patients With Ischemic Stroke During Transfer for Mechanical Thrombectomy. JAMA Neurology 2017, 74: 1361-1367. PMID: 28973081, PMCID: PMC5710581, DOI: 10.1001/jamaneurol.2017.2149.Peer-Reviewed Original ResearchConceptsThrombectomy-capable stroke centersCollateral blood flowIschemic strokeInfarct progressionMechanical thrombectomyCT angiographyMAIN OUTCOMEVessel statusBlood flowImaging factorsHigher adjusted odds ratioVascular imagingFavorable imaging profileHealth Stroke ScoreAcute ischemic strokeHigher National InstitutesAdjusted odds ratioRegional stroke networkStroke care networksStroke centersStroke ScoreConsecutive patientsStroke NetworkClinical severityFutile transfers
2014
Time and Diffusion Lesion Size in Major Anterior Circulation Ischemic Strokes
Hakimelahi R, Vachha B, Copen W, Papini G, He J, Higazi M, Lev M, Schaefer P, Yoo A, Schwamm L, González R. Time and Diffusion Lesion Size in Major Anterior Circulation Ischemic Strokes. Stroke 2014, 45: 2936-2941. PMID: 25190444, DOI: 10.1161/strokeaha.114.005644.Peer-Reviewed Original ResearchConceptsAnterior circulation ischemic strokeMiddle cerebral artery occlusionDiffusion-weighted imagingCerebral artery occlusionStroke onsetIschemic strokeInfarct sizeDWI lesionsInfarct volumeArtery occlusionIntravenous tissue-type plasminogen activatorProximal middle cerebral arteryDistal internal carotid arteryAcute infarct volumeDWI lesion volumeMajority of patientsMiddle cerebral arteryInternal carotid arteryAcute infarct sizeSame inclusion criteriaTraditional time windowTissue-type plasminogen activatorCerebral perfusionConsecutive patientsInfarct growth
2008
Clinical- and Imaging-Based Prediction of Stroke Risk After Transient Ischemic Attack
Ay H, Arsava E, Johnston S, Vangel M, Schwamm L, Furie K, Koroshetz W, Sorensen A. Clinical- and Imaging-Based Prediction of Stroke Risk After Transient Ischemic Attack. Stroke 2008, 40: 181-186. PMID: 18948609, DOI: 10.1161/strokeaha.108.521476.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrainComorbidityComputer SimulationDiffusion Magnetic Resonance ImagingDisease ProgressionEarly DiagnosisEmergency Medical ServicesFemaleHumansIncidenceIschemic Attack, TransientLogistic ModelsMaleMiddle AgedNeurologic ExaminationPredictive Value of TestsPrognosisReproducibility of ResultsRisk FactorsStrokeConceptsTransient ischemic attackIschemic attackStroke riskClinical featuresDiffusion-weighted imagingAcute infarctsClinical transient ischemic attackDiffusion-weighted imaging findingsEarly stroke riskRelevant clinical settingsCharacteristic curveLogistic regression modelsConsecutive patientsSymptom onsetIndependent predictorsRisk stratificationImaging findingsTherapeutic measuresHospital resourcesEarly riskClinical settingResponse criteriaPredictive instrumentStrokeSubsequent stroke
1999
Diffusion-Weighted Imaging Identifies a Subset of Lacunar Infarction Associated With Embolic Source
Ay H, Oliveira-Filho J, Buonanno F, Ezzeddine M, Schaefer P, Rordorf G, Schwamm L, Gonzalez R, Koroshetz W. Diffusion-Weighted Imaging Identifies a Subset of Lacunar Infarction Associated With Embolic Source. Stroke 1999, 30: 2644-2650. PMID: 10582991, DOI: 10.1161/01.str.30.12.2644.Peer-Reviewed Original ResearchConceptsLacunar syndromeSmall infarctsIdentifiable causeClinical syndromeCareful pathological studyClassic lacunar syndromeDWI hyperintense lesionsSingle lacunar infarctionBrain stem lesionsDay of admissionDistinct clinical syndromeDiffusion-weighted imagingMultiple infarctionsEmbolic mechanismEmbolic sourceArtery territoryClinical characteristicsLacunar infarctionSecondary preventionConsecutive patientsAcute lesionsIndex lesionSuch infarctsEmergency roomPathological studies
1998
Time Course of Lesion Development in Patients With Acute Stroke
Schwamm L, Koroshetz W, Sorensen A, Wang B, Copen W, Budzik R, Rordorf G, Buonanno F, Schaefer P, Gonzalez R. Time Course of Lesion Development in Patients With Acute Stroke. Stroke 1998, 29: 2268-2276. PMID: 9804633, DOI: 10.1161/01.str.29.11.2268.Peer-Reviewed Original ResearchConceptsApparent diffusion coefficient ratioDWI lesion volumeInitial DWI lesion volumeAcute ischemic strokeT2 lesion volumeLesion volumeNeurological outcomeIschemic strokeDiffusion-weighted imaging (DWI) lesion volumeHealth Stroke Scale scoreFinal lesion volumeImaging Lesion VolumeMaximum lesion volumePatients' neurological outcomeProgressive ischemic injurySecond scanStroke Scale scoreAcute stroke patientsSecondary pathophysiological processesAcute strokeStroke onsetSymptom onsetNeurological examinationInitial imagingIschemic injury