2021
Usefulness of Rhythm Monitoring Following Acute Ischemic Stroke
Khurshid S, Li X, Ashburner J, Lipsanopoulos A, Lee P, Lin A, Ko D, Ellinor P, Schwamm L, Benjamin E, Atlas S, Singer D, Anderson C, Trinquart L, Lubitz S. Usefulness of Rhythm Monitoring Following Acute Ischemic Stroke. The American Journal Of Cardiology 2021, 147: 44-51. PMID: 33617814, DOI: 10.1016/j.amjcard.2021.01.038.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeIschemic strokeCryptogenic strokeCause-specific hazards regressionCHARGE-AF scoreAtrial fibrillation riskRisk of deathFine-Gray modelCHARGE-AFIncident AFPrevalent AFDischarge dispositionStroke subtypesConsecutive patientsAF riskHazards regressionStroke survivorsAssessed associationsRhythm monitoringStrokeAF scorePatientsIncidenceOne-thirdRisk
2019
Intravenous Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients With History of Stroke Plus Diabetes Mellitus
Ehrlich M, Liang L, Xu H, Kosinski A, Hernandez A, Schwamm L, Smith E, Fonarow G, Bhatt D, Peterson E, Xian Y. Intravenous Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients With History of Stroke Plus Diabetes Mellitus. Stroke 2019, 50: 1497-1503. PMID: 31035901, PMCID: PMC6538420, DOI: 10.1161/strokeaha.118.024172.Peer-Reviewed Original ResearchConceptsIntravenous tissue-type plasminogen activatorSymptomatic intracerebral hemorrhageAcute ischemic strokeHistory of strokeTissue-type plasminogen activatorIschemic stroke patientsDiabetes mellitusIschemic strokeIntracerebral hemorrhagePlasminogen activatorStroke patientsUnadjusted ratesAcute ischemic stroke patientsBaseline clinical factorsConcomitant diabetes mellitusECASS III trialGuidelines-Stroke registryPrior ischemic strokeCardiovascular risk factorsHospital mortalityPrior strokeSevere strokeIII trialsClinical factorsRisk factorsRelation of Admission Blood Pressure to In-hospital and 90-Day Outcomes in Patients Presenting With Transient Ischemic Attack
Bangalore S, Schwamm L, Smith E, Hellkamp A, Xian Y, Schulte P, Saver J, Fonarow G, Bhatt D, Committee and Investigators F. Relation of Admission Blood Pressure to In-hospital and 90-Day Outcomes in Patients Presenting With Transient Ischemic Attack. The American Journal Of Cardiology 2019, 123: 1083-1095. PMID: 30685057, DOI: 10.1016/j.amjcard.2018.12.037.Peer-Reviewed Original ResearchConceptsTransient ischemic attackSystolic blood pressureAdmission blood pressureDiastolic blood pressureMean arterial pressureBlood pressureIschemic attackPulse pressureHospital outcomesPostdischarge outcomesArterial pressureLower admission systolic blood pressureAdmission systolic blood pressureHigher admission blood pressureLower systolic blood pressureGuidelines-Stroke registryMajor cardiovascular eventsAdmission systolicPostdischarge mortalityCardiovascular eventsCardiovascular readmissionHospital deathInverse associationHigh riskPatients
2018
Shock Index Predicts Patient‐Related Clinical Outcomes in Stroke
Myint P, Sheng S, Xian Y, Matsouaka R, Reeves M, Saver J, Bhatt D, Fonarow G, Schwamm L, Smith E. Shock Index Predicts Patient‐Related Clinical Outcomes in Stroke. Journal Of The American Heart Association 2018, 7: e007581. PMID: 30371191, PMCID: PMC6222962, DOI: 10.1161/jaha.117.007581.Peer-Reviewed Original ResearchConceptsShock indexClinical outcomesWorse outcomesPatient-related clinical outcomesHealth Stroke ScaleBlood pressure componentsAcute stroke casesRankin Scale scoreSystolic blood pressureUseful prognostic indicatorMortality prediction modelIndividual stroke subtypesLinear spline modelsHospital mortalityHospital outcomesHospital stayStroke ScaleAcute strokeDischarge destinationBlood pressureStroke subtypesPoint of carePoor outcomePrognostic valueStroke cases
2017
Ischemic Stroke Profile, Risk Factors, and Outcomes in India
Sylaja P, Pandian J, Kaul S, Srivastava M, Khurana D, Schwamm L, Kesav P, Arora D, Pannu A, Thankachan T, Singhal A. Ischemic Stroke Profile, Risk Factors, and Outcomes in India. Stroke 2017, 49: 219-222. PMID: 29167386, PMCID: PMC5742046, DOI: 10.1161/strokeaha.117.018700.Peer-Reviewed Original ResearchConceptsAdmission National InstitutesHealth Stroke ScaleStroke ScaleIschemic strokeDiabetes mellitusRisk factorsHealth Stroke Scale scoreLower admission National InstitutesMedian admission National InstitutesNational InstituteRankin Scale score 0Stroke etiologic subtypesIntra-arterial thrombolysisStroke Scale scoreAcademic tertiary hospitalCommon risk factorsMagnetic resonance imagingHospital mortalityEtiologic subtypesStroke careStroke ProjectTertiary hospitalAtrial fibrillationStroke guidelinesMean ageStroke of Known Cause and Underlying Atrial Fibrillation (STROKE-AF) randomized trial: Design and rationale
Bernstein R, Kamel H, Granger C, Kowal R, Ziegler P, Schwamm L. Stroke of Known Cause and Underlying Atrial Fibrillation (STROKE-AF) randomized trial: Design and rationale. American Heart Journal 2017, 190: 19-24. PMID: 28760209, DOI: 10.1016/j.ahj.2017.04.007.Peer-Reviewed Original ResearchConceptsApparent atrial fibrillationInsertable cardiac monitorSmall vessel diseaseLarge vessel atherosclerosisStandard of careVessel diseaseIschemic strokeAtrial fibrillationPost-market clinical trialArrhythmia monitoringSecondary stroke preventionOral anticoagulation therapyContinuous arrhythmia monitoringAntithrombotic treatmentOral anticoagulationAnticoagulation therapyStroke preventionIntracranial atherosclerosisStroke etiologyClinical trialsIncidence rateCardiac monitorPatientsCardiac monitoringStrokeHealthcare Resource Availability, Quality of Care, and Acute Ischemic Stroke Outcomes
O'Brien E, Wu J, Zhao X, Schulte P, Fonarow G, Hernandez A, Schwamm L, Peterson E, Bhatt D, Smith E. Healthcare Resource Availability, Quality of Care, and Acute Ischemic Stroke Outcomes. Journal Of The American Heart Association 2017, 6: e003813. PMID: 28159820, PMCID: PMC5523738, DOI: 10.1161/jaha.116.003813.Peer-Reviewed Original ResearchConceptsHealthcare resource availabilityHospital referral regionsQuality of careReferral regionsHealthcare resourcesAcute ischemic stroke outcomesAcute ischemic stroke treatmentGuidelines-Stroke hospitalsIschemic stroke outcomeIschemic stroke patientsIschemic stroke treatmentMultivariable logistic regressionLength of stayHospital-based resourcesGuidelines-StrokeHospital mortalityHospital outcomesStroke outcomeStroke careStroke treatmentStroke patientsCare resourcesHealth care dataHospital qualityStroke quality
2012
Care and Outcomes of Hispanic Patients Admitted With Heart Failure With Preserved or Reduced Ejection Fraction
Vivo R, Krim S, Krim N, Zhao X, Hernandez A, Peterson E, Piña I, Bhatt D, Schwamm L, Fonarow G. Care and Outcomes of Hispanic Patients Admitted With Heart Failure With Preserved or Reduced Ejection Fraction. Circulation Heart Failure 2012, 5: 167-175. PMID: 22414939, DOI: 10.1161/circheartfailure.111.963546.Peer-Reviewed Original ResearchConceptsNon-Hispanic whitesEjection fractionHeart failureQuality of careHF patientsNon-Hispanic white patientsLeft ventricular ejection fractionGuidelines-Heart FailureVentricular ejection fractionOverweight/obesityLower mortality riskPercent of HispanicsHospital survivalInpatient mortalityWhite patientsHispanic patientsHispanic ethnicityMortality riskHigh riskEquitable carePerformance improvement programMultivariate analysisPatientsStudy periodCareSex differences in in-hospital mortality in acute decompensated heart failure with reduced and preserved ejection fraction
Hsich E, Grau-Sepulveda M, Hernandez A, Peterson E, Schwamm L, Bhatt D, Fonarow G. Sex differences in in-hospital mortality in acute decompensated heart failure with reduced and preserved ejection fraction. American Heart Journal 2012, 163: 430-437.e3. PMID: 22424014, DOI: 10.1016/j.ahj.2011.12.013.Peer-Reviewed Original ResearchConceptsHospital mortalityHeart failureRisk factorsHF patientsEjection fractionAcute decompensated heart failureRenal failure/dialysisGuidelines-Heart FailureDecompensated heart failurePrimary end pointPeripheral vascular diseaseSystolic blood pressureCoronary artery diseaseValvular heart diseaseEquation logistic modelsSex differencesMulticenter registryBaseline characteristicsArtery diseaseBlood pressureHospital clusteringHospitalized patientsStudy cohortVascular diseaseHeart disease
2010
Cost-Effectiveness of CT Perfusion for Selecting Patients for Intravenous Thrombolysis: A US Hospital Perspective
Jackson D, Earnshaw S, Farkouh R, Schwamm L. Cost-Effectiveness of CT Perfusion for Selecting Patients for Intravenous Thrombolysis: A US Hospital Perspective. American Journal Of Neuroradiology 2010, 31: 1669-1674. PMID: 20538823, PMCID: PMC7965001, DOI: 10.3174/ajnr.a2138.Peer-Reviewed Original ResearchConceptsHospital perspectiveUnenhanced CTExtent of penumbraLife-year savedUS hospital perspectiveAcute stroke evaluationSelection of patientsCT-based methodClinical trial dataDecision analytic modelCTP selectionIntravenous thrombolysisIschemic strokeClinical outcomesStroke evaluationPatient populationCT perfusionFavorable outcomeRoutine CTClinical trialsPatientsTrial dataMultivariate sensitivity analysisHospitalTPA treatment
2008
CT Angiography-Source Image Hypoattenuation Predicts Clinical Outcome in Posterior Circulation Strokes Treated With Intra-Arterial Therapy
Schaefer P, Yoo A, Bell D, Barak E, Romero J, Nogueira R, Lev M, Schwamm L, Gonzalez R, Hirsch J. CT Angiography-Source Image Hypoattenuation Predicts Clinical Outcome in Posterior Circulation Strokes Treated With Intra-Arterial Therapy. Stroke 2008, 39: 3107-3109. PMID: 18703807, DOI: 10.1161/strokeaha.108.517680.Peer-Reviewed Original ResearchConceptsIntra-arterial thrombolysisVertebrobasilar occlusionClinical outcomesParenchymal hypoattenuationRankin scorePosterior circulation strokeHealth Stroke ScaleIntra-arterial therapyOnly independent predictorIndependent outcome predictorsMedial temporal lobeInferior parietal lobeStroke ScaleClot locationPatient ageCTA-SIIndependent predictorsOutcome predictorsOccipital lobeHypoattenuationTemporal lobeThrombolysisParietal lobePatientsMidbrain
2004
Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury.
Huisman T, Schwamm L, Schaefer P, Koroshetz W, Shetty-Alva N, Ozsunar Y, Wu O, Sorensen A. Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. American Journal Of Neuroradiology 2004, 25: 370-6. PMID: 15037457, PMCID: PMC8158566.Peer-Reviewed Original ResearchConceptsGlasgow Coma ScaleDiffusion tensor imagingTraumatic brain injuryRankin scoreInternal capsuleApparent diffusion coefficientADC valuesFA valuesWhite matter injuryHealthy control subjectsDiffuse axonal injuryCorresponding ADC valuesFractional anisotropy valuesNew MR imaging techniquesTBI correlatesComa ScaleClinical scoresAxonal injuryControl subjectsBrain injuryClinical markersMR imaging techniquesTissue injuryBrain ultrastructureWhite matter