2022
Comparative Effectiveness and Safety of Seizure Prophylaxis Among Adults After Acute Ischemic Stroke
Moura L, Donahue M, Yan Z, Smith L, Hsu J, Newhouse J, Schwamm L, Haneuse S, Hernandez-Diaz S, Blacker D. Comparative Effectiveness and Safety of Seizure Prophylaxis Among Adults After Acute Ischemic Stroke. Stroke 2022, 54: 527-536. PMID: 36544249, PMCID: PMC9870933, DOI: 10.1161/strokeaha.122.039946.Peer-Reviewed Original ResearchConceptsSeizure prophylaxisRisk differenceAntiseizure drugsEarly seizure prophylaxisSevere AIS patientsAcute ischemic strokePrespecified subgroup analysisHealth care factorsInverse probability weightsElectronic health recordsAIS admissionsPoststroke mortalityStroke RegistryIschemic strokeAIS patientsStroke settingsCare factorsSubgroup analysisProphylaxisMortality riskHigh riskPatientsComparative effectivenessExcess deathsTrial dataIschemic Stroke Systems of Care in California: Evolution in the Organization During the Mechanical Thrombectomy Era
Zachrison K, Hsia R, Li S, Reeves M, Camargo C, Yan Z, Onnela J, Schwamm L. Ischemic Stroke Systems of Care in California: Evolution in the Organization During the Mechanical Thrombectomy Era. Stroke Vascular And Interventional Neurology 2022, 2 DOI: 10.1161/svin.121.000206.Peer-Reviewed Original ResearchEndovascular thrombectomyStroke systemsHospital-level factorsOdds of transferLogistic regression modelsAlteplase useEVT proceduresStroke NetworkObservational studyTimely careRural hospitalsTrial dataHospitalPatientsHospital postsHospital pairsCarePatient transfer networksRegression modelsNumber of encountersLinear regressionThrombectomyAlteplaseRegressionGreater POST
2017
Visual Aids for Patient, Family, and Physician Decision Making About Endovascular Thrombectomy for Acute Ischemic Stroke
Tokunboh I, Vales Montero M, Zopelaro Almeida M, Sharma L, Starkman S, Szeder V, Jahan R, Liebeskind D, Gonzalez N, Demchuk A, Froehler M, Goyal M, Lansberg M, Lutsep H, Schwamm L, Saver J. Visual Aids for Patient, Family, and Physician Decision Making About Endovascular Thrombectomy for Acute Ischemic Stroke. Stroke 2017, 49: 90-97. PMID: 29222229, DOI: 10.1161/strokeaha.117.018715.Peer-Reviewed Original ResearchConceptsAcute cerebral ischemiaEndovascular thrombectomyBetter disability outcomesCerebral ischemiaDisability outcomesTPA-eligible patientsAcute ischemic strokeLarge vessel occlusionReperfusion treatmentTerritory infarctsIschemic strokeRankin ScaleVessel occlusionThrombectomyPatientsPhysician's decisionHealthcare providersTrial dataAdverse effectsOutcomesTreatment effectsIschemiaVisual decision aidsTPADecision aid
2011
Thrombolysis Treatment for Acute Stroke: Issues of Efficacy and Utilization in Women
Reeves M, Wilkins T, Lisabeth L, Schwamm L. Thrombolysis Treatment for Acute Stroke: Issues of Efficacy and Utilization in Women. Women's Health 2011, 7: 383-390. PMID: 21612358, DOI: 10.2217/whe.11.31.Peer-Reviewed Original ResearchConceptsThrombolysis treatmentIschemic strokeObservational studyTPA treatmentSex differencesAcute ischemic strokeComparable control groupImportant sex differencesIssues of efficacyThrombolysis trialsAcute strokeStroke communityTreatment efficacyControl groupGreater efficacyTrial dataStrokeWomenEfficacyLow utilizationGood evidenceMore studiesTreatmentMenWide variability
2010
Cost-Effectiveness of CT Perfusion for Selecting Patients for Intravenous Thrombolysis: A US Hospital Perspective
Jackson D, Earnshaw S, Farkouh R, Schwamm L. Cost-Effectiveness of CT Perfusion for Selecting Patients for Intravenous Thrombolysis: A US Hospital Perspective. American Journal Of Neuroradiology 2010, 31: 1669-1674. PMID: 20538823, PMCID: PMC7965001, DOI: 10.3174/ajnr.a2138.Peer-Reviewed Original ResearchConceptsHospital perspectiveUnenhanced CTExtent of penumbraLife-year savedUS hospital perspectiveAcute stroke evaluationSelection of patientsCT-based methodClinical trial dataDecision analytic modelCTP selectionIntravenous thrombolysisIschemic strokeClinical outcomesStroke evaluationPatient populationCT perfusionFavorable outcomeRoutine CTClinical trialsPatientsTrial dataMultivariate sensitivity analysisHospitalTPA treatment