2015
Treatment patterns and short-term outcomes in ischemic stroke in pregnancy or postpartum period
Leffert LR, Clancy CR, Bateman BT, Cox M, Schulte PJ, Smith EE, Fonarow GC, Kuklina EV, George MG, Schwamm LH. Treatment patterns and short-term outcomes in ischemic stroke in pregnancy or postpartum period. American Journal Of Obstetrics And Gynecology 2015, 214: 723.e1-723.e11. PMID: 26709084, DOI: 10.1016/j.ajog.2015.12.016.Peer-Reviewed Original ResearchConceptsAcute stroke reperfusion therapyStroke reperfusion therapyShort-term outcomesTissue plasminogen activatorGuidelines-Stroke registryPregnancy-related strokeReperfusion therapyIschemic stroke patientsIschemic strokeNonpregnant womenPostpartum womenStroke patientsPlasminogen activatorPostpartum periodIntravenous tissue plasminogen activator useIntravenous tissue plasminogen activatorFavorable short-term outcomesTissue plasminogen activator useAcute reperfusion therapyCatheter-based thrombolysisGreater stroke severityMajor systemic bleedingNonpregnant women 18Symptomatic intracranial hemorrhageHistory of hypertension
2014
Intravenous Fibrinolysis Eligibility: A Survey of Stroke Clinicians' Practice Patterns and Review of the Literature
De Los Rios F, Kleindorfer D, Guzik A, Ortega-Gutierrez S, Sangha N, Kumar G, Grotta J, Lee J, Meyer B, Schwamm L, Khatri P, Investigators S. Intravenous Fibrinolysis Eligibility: A Survey of Stroke Clinicians' Practice Patterns and Review of the Literature. Journal Of Stroke And Cerebrovascular Diseases 2014, 23: 2130-2138. PMID: 25113084, PMCID: PMC4157964, DOI: 10.1016/j.jstrokecerebrovasdis.2014.03.024.Peer-Reviewed Original ResearchConceptsStroke cliniciansPractice patternsEligible patientsSymptom onsetEuropean Cooperative Acute Stroke Study-III criteriaIntravenous recombinant tissue plasminogen activator useCurrent American Heart Association guidelinesRecombinant tissue plasminogen activator useTissue plasminogen activator useAmerican Heart Association guidelinesHealth Stroke ScaleHeart Association guidelinesHour time frameClinician practice patternsNational InstituteSevere strokeStroke ScaleIschemic strokeMild strokeAssociation guidelinesMost cliniciansElderly individualsEligibility criteriaDrug AdministrationInvestigator meetingSeverity of leukoaraiosis, leptomeningeal collaterals, and clinical outcomes after intra-arterial therapy in patients with acute ischemic stroke
Giurgiutiu D, Yoo A, Fitzpatrick K, Chaudhry Z, Leslie-Mazwi T, Schwamm L, Rost N. Severity of leukoaraiosis, leptomeningeal collaterals, and clinical outcomes after intra-arterial therapy in patients with acute ischemic stroke. Journal Of NeuroInterventional Surgery 2014, 7: 326. PMID: 24721756, DOI: 10.1136/neurintsurg-2013-011083.Peer-Reviewed Original ResearchConceptsIntra-arterial therapyProximal artery occlusionAcute ischemic strokeSeverity of leukoaraiosisGood functional outcomeLA volumeCollateral gradeRecanalization statusArtery occlusionIschemic strokeFunctional outcomeIntravenous tissue plasminogen activator useHealth Stroke Scale scoreLarge cerebral artery occlusionPoor post-stroke outcomesIschemic white matter lesionsTissue plasminogen activator useGood collateral gradesGreater LA volumeGuidelines-Stroke databasePoor collateral gradeStroke Scale scoreSymptomatic intracranial hemorrhageCerebral artery occlusionCerebral small vessels
2013
Temporal Trends in Patient Characteristics and Treatment With Intravenous Thrombolysis Among Acute Ischemic Stroke Patients at Get With the Guidelines–Stroke Hospitals
Schwamm L, Ali S, Reeves M, Smith E, Saver J, Messe S, Bhatt D, Grau-Sepulveda M, Peterson E, Fonarow G. Temporal Trends in Patient Characteristics and Treatment With Intravenous Thrombolysis Among Acute Ischemic Stroke Patients at Get With the Guidelines–Stroke Hospitals. Circulation Cardiovascular Quality And Outcomes 2013, 6: 543-549. DOI: 10.1161/circoutcomes.111.000095.Peer-Reviewed Original ResearchAcute ischemic stroke patientsIschemic stroke patientsTPA useAIS patientsPatient characteristicsStroke patientsHospitalized acute ischemic stroke patientsIntravenous tissue plasminogen activator useTissue plasminogen activator useNonwhite race/ethnicityAdditional calendar yearGuidelines-Stroke hospitalsAmerican Heart AssociationRace/ethnicityAIS admissionsGuidelines-StrokeEligible patientsIntravenous thrombolysisIntravenous tPAMore patientsMultivariable analysisHeart AssociationMild strokeTPA timeUnivariate analysisTemporal trends in patient characteristics and treatment with intravenous thrombolysis among acute ischemic stroke patients at Get With The Guidelines-Stroke hospitals.
Schwamm L, Ali S, Reeves M, Smith E, Saver J, Messe S, Bhatt D, Grau-Sepulveda M, Peterson E, Fonarow G. Temporal trends in patient characteristics and treatment with intravenous thrombolysis among acute ischemic stroke patients at Get With The Guidelines-Stroke hospitals. Circulation Cardiovascular Quality And Outcomes 2013, 6: 543-9. PMID: 24046398, DOI: 10.1161/circoutcomes.111.000303.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAge FactorsAgedAged, 80 and overAmerican Heart AssociationBrain IschemiaChi-Square DistributionFemaleFibrinolytic AgentsHospitalsHumansMaleMiddle AgedMultivariate AnalysisOdds RatioQuality Indicators, Health CareRegistriesRisk FactorsStrokeThrombolytic TherapyTime FactorsTime-to-TreatmentTissue Plasminogen ActivatorTreatment OutcomeUnited StatesConceptsAcute ischemic stroke patientsIschemic stroke patientsTPA useAIS patientsPatient characteristicsStroke patientsHospitalized acute ischemic stroke patientsIntravenous tissue plasminogen activator useTissue plasminogen activator useNonwhite race/ethnicityAdditional calendar yearGuidelines-Stroke hospitalsAmerican Heart AssociationRace/ethnicityAIS admissionsGuidelines-StrokeEligible patientsIntravenous thrombolysisIntravenous tPAMore patientsMultivariable analysisHeart AssociationMild strokeTPA timeUnivariate analysis
2012
Predictors of Increased Intravenous Tissue Plasminogen Activator Use Among Hospitals Participating in the Massachusetts Primary Stroke Service Program
Rost N, Smith E, Pervez M, Mello P, Dreyer P, Schwamm L. Predictors of Increased Intravenous Tissue Plasminogen Activator Use Among Hospitals Participating in the Massachusetts Primary Stroke Service Program. Circulation Cardiovascular Quality And Outcomes 2012, 5: 314-320. PMID: 22534407, PMCID: PMC3361890, DOI: 10.1161/circoutcomes.111.962829.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overEmergency Service, HospitalFemaleFibrinolytic AgentsHealthcare DisparitiesHumansInfusions, IntravenousLinear ModelsLogistic ModelsMaleMassachusettsMiddle AgedMultivariate AnalysisOdds RatioPatient SelectionPractice Guidelines as TopicQuality ImprovementRegional Medical ProgramsRetrospective StudiesRisk AssessmentRisk FactorsStrokeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorTreatment OutcomeConceptsIntravenous tissue plasminogen activator useTissue plasminogen activator useAcute ischemic strokeTPA useIschemic strokeOlder acute ischemic stroke patientsAcute ischemic stroke patientsGuidelines-Stroke programStroke center designationIschemic stroke patientsRate of thrombolysisQuality improvement initiativesEmergency medical servicesStroke onsetSymptom onsetStroke patientsTreatment disparitiesCenter designationPatientsHospitalMassachusetts DepartmentImprovement initiativesMedical servicesOverall rateFurther studiesGet With The Guidelines Stroke Performance Indicators in a Brazilian Tertiary Hospital
de Carvalho F, Schwamm L, Kuster G, Alves M, Neto M, Silva G. Get With The Guidelines Stroke Performance Indicators in a Brazilian Tertiary Hospital. Cerebrovascular Diseases Extra 2012, 2: 26-35. PMID: 22811686, PMCID: PMC3398824, DOI: 10.1159/000339578.Peer-Reviewed Original ResearchDeep vein thrombosis prophylaxisGWTG-Stroke programEligible patientsBrazilian tertiary hospitalThrombosis prophylaxisAntithrombotic medicationStroke ProgramSymptom onsetTertiary hospitalAtrial fibrillationSmoking cessationDischarge useNational Cholesterol Education Program Adult Treatment Panel III guidelinesAmerican Heart Association/American Stroke AssociationAdult Treatment Panel III guidelinesAdult long-term disabilityTissue plasminogen activator useAntithrombotic medication useNCEP III guidelinesStroke quality improvementTransient ischemic attackAcute ischemic strokeAmerican Stroke AssociationClinical practice guidelinesLong-term disability
2011
Use of Telemedicine and Other Strategies to Increase the Number of Patients That May Be Treated with Intravenous Thrombolysis
Silva G, Schwamm L. Use of Telemedicine and Other Strategies to Increase the Number of Patients That May Be Treated with Intravenous Thrombolysis. Current Neurology And Neuroscience Reports 2011, 12: 10-16. PMID: 21997715, DOI: 10.1007/s11910-011-0235-6.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeUse of telemedicineIntravenous thrombolysisIschemic strokeIntravenous tissue plasminogen activator useAdult long-term disabilityTissue plasminogen activator useLong-term disabilityAmerican Heart AssociationNumber of patientsRecruitment of patientsRate of treatmentHelp of telemedicineThrombolysis trialsHeart AssociationStroke NetworkStroke systemsTelestroke networkTelestroke systemCurrent evidencePatientsThrombolysisStrokeCareTelemedicine