2022
Sex Differences in Endovascular Therapy for Ischemic Stroke: Results From the Get With The Guidelines–Stroke Registry
Demel S, Reeves M, Xu H, Xian Y, Mac Grory B, Fonarow G, Matsouaka R, Smith E, Saver J, Schwamm L. Sex Differences in Endovascular Therapy for Ischemic Stroke: Results From the Get With The Guidelines–Stroke Registry. Stroke 2022, 53: 3099-3106. PMID: 35880521, DOI: 10.1161/strokeaha.122.038491.Peer-Reviewed Original ResearchConceptsEndovascular therapyIschemic strokeHealth Stroke Scale scoreTreatment ratesGuidelines-Stroke hospitalsGuidelines-Stroke registryStroke Scale scoreAcute ischemic strokeSex differencesLarge vessel occlusionMultivariable regression analysisIschemic stroke dischargesEVT useHospital deathHospital mortalityASA guidelinesVessel occlusionOdds ratioScale scoreStroke dischargesSignificant sex differencesWomenNational InstituteMenStatistical adjustmentSystematic Review of Sex Differences in Ischemic Strokes Among Young Adults: Are Young Women Disproportionately at Risk?
Leppert M, Burke J, Lisabeth L, Madsen T, Kleindorfer D, Sillau S, Schwamm L, Daugherty S, Bradley C, Ho P, Poisson S. Systematic Review of Sex Differences in Ischemic Strokes Among Young Adults: Are Young Women Disproportionately at Risk? Stroke 2022, 53: 319-327. PMID: 35073188, PMCID: PMC8852306, DOI: 10.1161/strokeaha.121.037117.Peer-Reviewed Original ResearchConceptsIschemic strokeIncidence rate ratiosYoung adultsStroke incidenceSex-specific incidence rate ratiosSystematic reviewAge groupsSex differencesYoung womenMore womenRate ratioAdults 35Incidence rateStroke typeHigh riskAge adjustmentStrokeSignificant sex differencesRelevant articlesMore menWomenNonsignificant sex differencesAdultsRecent evidenceMen
2016
Sex and Age Interactions and Differences in Outcomes After Intracerebral Hemorrhage
James M, Cox M, Xian Y, Smith E, Bhatt D, Schulte P, Hernandez A, Fonarow G, Schwamm L. Sex and Age Interactions and Differences in Outcomes After Intracerebral Hemorrhage. Journal Of Women's Health 2016, 26: 380-388. PMID: 27754758, DOI: 10.1089/jwh.2016.5849.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageSex-based interactionsTotal study populationWorse neurological deficitsAge/sexSex differencesAntiplatelet therapyHospital mortalityIschemic strokeNeurological deficitsPatient ageIndependent ambulationICH patientsStroke databaseAtrial fibrillationEarly outcomesPoor outcomeStudy populationCholesterol reducersLogistic regressionWomenTreatment differencesAgeMenHemorrhage
2015
Racial/Ethnic and Sex Differences in Emergency Medical Services Transport Among Hospitalized US Stroke Patients: Analysis of the National Get With The Guidelines–Stroke Registry
Mochari-Greenberger H, Xian Y, Hellkamp A, Schulte P, Bhatt D, Fonarow G, Saver J, Reeves M, Schwamm L, Smith E. Racial/Ethnic and Sex Differences in Emergency Medical Services Transport Among Hospitalized US Stroke Patients: Analysis of the National Get With The Guidelines–Stroke Registry. Journal Of The American Heart Association 2015, 4: e002099. PMID: 26268882, PMCID: PMC4599467, DOI: 10.1161/jaha.115.002099.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsianBlack or African AmericanChi-Square DistributionEmergency Medical ServicesFemaleHealth Knowledge, Attitudes, PracticeHispanic or LatinoHospitalizationHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPatient Acceptance of Health CareRegistriesSex FactorsStrokeTransportation of PatientsUnited StatesWhite PeopleConceptsEmergency medical servicesStroke patientsStroke symptomsEMS useRace/ethnicityHospitalized acute stroke patientsEmergency medical services transportWhite womenGuidelines-Stroke registryAcute stroke patientsMultivariable logistic regressionLevel of consciousnessSex differencesGuidelines-StrokeNational GetIschemic strokeStroke outcomePatient characteristicsPotential confoundersMedical historyEMS transportSex disparitiesPatientsHispanic menLogistic regression
2012
Sex differences in in-hospital mortality in acute decompensated heart failure with reduced and preserved ejection fraction
Hsich E, Grau-Sepulveda M, Hernandez A, Peterson E, Schwamm L, Bhatt D, Fonarow G. Sex differences in in-hospital mortality in acute decompensated heart failure with reduced and preserved ejection fraction. American Heart Journal 2012, 163: 430-437.e3. PMID: 22424014, DOI: 10.1016/j.ahj.2011.12.013.Peer-Reviewed Original ResearchConceptsHospital mortalityHeart failureRisk factorsHF patientsEjection fractionAcute decompensated heart failureRenal failure/dialysisGuidelines-Heart FailureDecompensated heart failurePrimary end pointPeripheral vascular diseaseSystolic blood pressureCoronary artery diseaseValvular heart diseaseEquation logistic modelsSex differencesMulticenter registryBaseline characteristicsArtery diseaseBlood pressureHospital clusteringHospitalized patientsStudy cohortVascular diseaseHeart disease
2011
Thrombolysis Treatment for Acute Stroke: Issues of Efficacy and Utilization in Women
Reeves M, Wilkins T, Lisabeth L, Schwamm L. Thrombolysis Treatment for Acute Stroke: Issues of Efficacy and Utilization in Women. Women's Health 2011, 7: 383-390. PMID: 21612358, DOI: 10.2217/whe.11.31.Peer-Reviewed Original ResearchConceptsThrombolysis treatmentIschemic strokeObservational studyTPA treatmentSex differencesAcute ischemic strokeComparable control groupImportant sex differencesIssues of efficacyThrombolysis trialsAcute strokeStroke communityTreatment efficacyControl groupGreater efficacyTrial dataStrokeWomenEfficacyLow utilizationGood evidenceMore studiesTreatmentMenWide variability
2009
Quality of Care in Women With Ischemic Stroke in the GWTG Program
Reeves M, Fonarow G, Zhao X, Smith E, Schwamm L. Quality of Care in Women With Ischemic Stroke in the GWTG Program. Stroke 2009, 40: 1127-1133. PMID: 19211482, DOI: 10.1161/strokeaha.108.543157.Peer-Reviewed Original ResearchConceptsQuality of careIschemic strokeAcute ischemic stroke admissionsMultivariable logistic regression modelDefect-free careGuidelines-Stroke programGWTG-Stroke programWorse poststroke outcomesIschemic stroke admissionsPast medical historySex differencesLogistic regression modelsSex-based differencesStroke admissionsCrude mortalityAtrial fibrillationMedical historyPoststroke outcomesHeart diseaseRisk adjustmentCareWomenFurther studiesMenStroke