Seizure Prophylaxis After Spontaneous Intracerebral Hemorrhage
Jones F, Sanches P, Smith J, Zafar S, Blacker D, Hsu J, Schwamm L, Newhouse J, Westover M, Moura L. Seizure Prophylaxis After Spontaneous Intracerebral Hemorrhage. JAMA Neurology 2021, 78: 1128-1136. PMID: 34309642, PMCID: PMC8314179, DOI: 10.1001/jamaneurol.2021.2249.Peer-Reviewed Original ResearchConceptsEarly seizure prophylaxisSpontaneous intracerebral hemorrhageAdverse drug reactionsRisk-guided strategyLate seizuresLong-term therapyHigh riskSeizure prophylaxisPrimary prophylaxisIntracerebral hemorrhageLower riskLong-term adverse drug reactionsLow-risk patientsShort-term prophylaxisDecision analytical modelSecondary therapyProphylaxis strategiesDrug reactionsProphylaxisMAIN OUTCOMESeizuresPatientsClinical decisionTherapyAverage riskAnticonvulsant Primary and Secondary Prophylaxis for Acute Ischemic Stroke Patients
Jones F, Sanches P, Smith J, Zafar S, Hernandez-Diaz S, Blacker D, Hsu J, Schwamm L, Westover M, Moura L. Anticonvulsant Primary and Secondary Prophylaxis for Acute Ischemic Stroke Patients. Stroke 2021, 52: 2782-2791. PMID: 34126758, PMCID: PMC8384723, DOI: 10.1161/strokeaha.120.033299.Peer-Reviewed Original ResearchConceptsQuality-adjusted life expectancySecondary prophylaxisAdverse drug reactionsADR riskLate seizuresPrimary prophylaxisMale patientsFemale patientsLifetime riskLS riskAcute ischemic stroke hospitalizationsLong-term secondary prophylaxisAcute ischemic stroke patientsHigher ADR risksAcute ischemic strokeIschemic stroke patientsIschemic stroke hospitalizationsCommon clinical scenariosShort-term therapyAnticonvulsant prophylaxisLifetime prophylaxisPersistent seizuresSeizure prophylaxisEarly seizuresIschemic stroke