2023
Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open-label, controlled trial
Xiong Y, Campbell B, Fisher M, Schwamm L, Parsons M, Li H, Pan Y, Meng X, Zhao X, Wang Y. Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open-label, controlled trial. Stroke And Vascular Neurology 2023, 9: 82-89. PMID: 37247876, PMCID: PMC10956103, DOI: 10.1136/svn-2023-002310.Peer-Reviewed Original ResearchLarge vessel occlusionAnterior circulation large vessel occlusionIschemic strokePerfusion-weighted imagingEfficacy outcomesReperfusion therapyMajor neurological improvementSecondary efficacy outcomesStandard medical therapyHealth Stroke ScalePrimary efficacy outcomeSymptomatic intracerebral hemorrhageRankin Scale scoreTissue-type plasminogen activatorDirect thrombectomyNeurological improvementStroke ScaleAnterior circulationMedical therapyMRS scoreIntracerebral hemorrhageSalvageable tissueVessel occlusionCT perfusionClinical trials
2019
Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy
Inohara T, Liang L, Kosinski A, Smith E, Schwamm L, Hernandez A, Bhatt D, Fonarow G, Peterson E, Xian Y. Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy. Journal Of The American Heart Association 2019, 8: e012450. PMID: 31327296, PMCID: PMC6761665, DOI: 10.1161/jaha.119.012450.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorRecent myocardial infarctionAcute ischemic strokeHistory of MIRisk of mortalityMyocardial infarctionAIS patientsIschemic strokeIntravenous recombinant tissue-type plasminogen activatorST-segment elevation myocardial infarctionSegment elevation myocardial infarctionMultivariate logistic regression modelGuidelines-Stroke hospitalsOnly medical therapyElevation myocardial infarctionTissue-type plasminogen activatorLogistic regression modelsHospital mortalityHospital outcomesSevere strokeMedical therapyThrombolytic therapyHigh riskInfarctionPatients
2016
Patient-reported financial barriers to adherence to treatment in neurology
Moura L, Schwamm E, Moura V, Seitz M, Hoch D, Hsu J, Schwamm L. Patient-reported financial barriers to adherence to treatment in neurology. ClinicoEconomics And Outcomes Research 2016, Volume 8: 685-694. PMID: 27895506, PMCID: PMC5117903, DOI: 10.2147/ceor.s119971.Peer-Reviewed Original ResearchMedication adherenceFinancial barriersPatient-reported failuresEffective medical therapyRoutine outpatient carePatient-reported dataCross-sectional surveyNeurology appointmentPatient characteristicsMedical therapyNeurology clinicMean agePrescription medicationsOutpatient careNeurological conditionsClinical informationNeurological diseasesNeurological disordersPatientsDemographic characteristicsAdherenceNonadherenceTherapyPreferred languageMedications
2012
Guideline Adherence After ST-Segment Elevation Versus Non-ST Segment Elevation Myocardial Infarction
Somma K, Bhatt D, Fonarow G, Cannon C, Cox M, Laskey W, Peacock W, Hernandez A, Peterson E, Schwamm L, Saxon L. Guideline Adherence After ST-Segment Elevation Versus Non-ST Segment Elevation Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2012, 5: 654-661. PMID: 22949493, DOI: 10.1161/circoutcomes.111.963959.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overCardiovascular AgentsChi-Square DistributionComorbidityCoronary Artery DiseaseDrug Administration ScheduleFemaleGuideline AdherenceHospitalsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioPractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRegistriesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionSTEMI patientsMedical therapyNSTEMI patientsMyocardial infarctionGuidelines-Coronary Artery Disease registryNon-ST segment elevation myocardial infarctionGuideline-based medical therapyPrior coronary artery diseaseSegment elevation myocardial infarctionLow-density lipoprotein levelsSegment elevation MISimilar medical therapyLipid-lowering medicationsCoronary artery diseaseST-segment elevationGWTG-CADMedical comorbiditiesDischarge medicationsGuideline adherenceArtery diseaseHeart failureAngiotensin receptorsElevation MI