2009
Feasibility of NIRS in the Neurointensive Care Unit: A Pilot Study in Stroke Using Physiological Oscillations
Muehlschlegel S, Selb J, Patel M, Diamond S, Franceschini M, Sorensen A, Boas D, Schwamm L. Feasibility of NIRS in the Neurointensive Care Unit: A Pilot Study in Stroke Using Physiological Oscillations. Neurocritical Care 2009, 11: 288. PMID: 19649749, PMCID: PMC2782535, DOI: 10.1007/s12028-009-9254-4.Peer-Reviewed Original ResearchConceptsCare unitStroke patientsPhysiological oscillationsHemoglobin concentrationMicrovascular hemodynamicsPilot studyIschemic brain injuryNeurointensive care unitNeurocritical care unitPre-hospital settingRespiratory oscillationsWarrants further validationAbsolute hemoglobin concentrationResultsNine patientsCerebral perfusionHemispheric strokeBrain injuryHealthy controlsFuture clinical applicationsPatientsOwn controlClinical feasibilityBedside modalityContinuous-wave NIRSClinical application
2001
Diagnostic Value of Apparent Diffusion Coefficient Hyperintensity in Selected Patients With Acute Neurologic Deficits
Schaefer P, Gonzalez R, Hunter G, Wang B, Koroshetz W, Schwamm L. Diagnostic Value of Apparent Diffusion Coefficient Hyperintensity in Selected Patients With Acute Neurologic Deficits. Journal Of Neuroimaging 2001, 11: 369-380. PMID: 11677876, DOI: 10.1111/j.1552-6569.2001.tb00065.x.Peer-Reviewed Original ResearchConceptsAcute neurologic deficitsMagnetic resonance imagingDiffusion-weighted imagingNeurologic deficitsMRI abnormalitiesClinical syndromeMRI T2 hyperintensityVenous sinus thrombosisIschemic brain injuryEvaluation of patientsSubset of patientsConventional magnetic resonance imagingApparent diffusion coefficient (ADC) mapsDiffusion coefficient mapsHIV encephalopathyHypertensive encephalopathyNonischemic etiologyPosterior leukoencephalopathySinus thrombosisCarotid endarterectomyT2 hyperintensityNeurologic conditionsVasogenic edemaBrain injuryDiffusion magnetic resonance imaging
1999
Normal diffusion-weighted MRI during stroke-like deficits
Ay H, Buonanno F, Rordorf G, Schaefer P, Schwamm L, Wu O, Gonzalez R, Yamada K, Sorensen G, Koroshetz W. Normal diffusion-weighted MRI during stroke-like deficits. Neurology 1999, 52: 1784-1792. PMID: 10371524, DOI: 10.1212/wnl.52.9.1784.Peer-Reviewed Original ResearchConceptsDiffusion-weighted MRICerebral ischemic eventsDWI abnormalitiesStroke mimicsIschemic eventsAcute ischemic strokeIschemic brain injuryTransient global amnesiaIschemic causePathophysiologic diagnosisLacunar syndromeNonischemic causesIschemic strokeLacunar infarctionNeurologic deficitsBrain ischemiaConsecutive patientsSuch patientsRadiologic dataFinal diagnosisBrain injuryCortical syndromesFunctional disordersEarly diagnosisGlobal amnesia
1998
Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke
Polidori M, Frei B, Cherubini A, Nelles G, Rordorf G, Keaney J, Schwamm L, Mecocci P, Koroshetz W, Beal M. Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke. Free Radical Biology And Medicine 1998, 25: 561-567. PMID: 9741593, DOI: 10.1016/s0891-5849(98)00085-9.Peer-Reviewed Original ResearchConceptsIschemic brain injuryCerebral syndromeCortical strokePlasma levelsBrain injuryOxidative stressGlasgow Coma ScaleNIH Stroke ScaleLipid hydroperoxidesStroke ScaleIschemic strokeComa ScaleLacunar infarctsStroke volumeMRI scansPatientsTherapeutic interventionsDay 5Significant negative correlationSignificant positive correlationSyndromeStrokeAscorbic acid concentrationInjuryPositive correlation