2019
Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy
Inohara T, Liang L, Kosinski A, Smith E, Schwamm L, Hernandez A, Bhatt D, Fonarow G, Peterson E, Xian Y. Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy. Journal Of The American Heart Association 2019, 8: e012450. PMID: 31327296, PMCID: PMC6761665, DOI: 10.1161/jaha.119.012450.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorRecent myocardial infarctionAcute ischemic strokeHistory of MIRisk of mortalityMyocardial infarctionAIS patientsIschemic strokeIntravenous recombinant tissue-type plasminogen activatorST-segment elevation myocardial infarctionSegment elevation myocardial infarctionMultivariate logistic regression modelGuidelines-Stroke hospitalsOnly medical therapyElevation myocardial infarctionTissue-type plasminogen activatorLogistic regression modelsHospital mortalityHospital outcomesSevere strokeMedical therapyThrombolytic therapyHigh riskInfarctionPatients
2012
Predictors of Adherence to Performance Measures in Patients with Acute Myocardial Infarction
Kumbhani D, Fonarow G, Cannon C, Hernandez A, Peterson E, Peacock W, Laskey W, Pan W, Schwamm L, Bhatt D, Committee and Investigators G. Predictors of Adherence to Performance Measures in Patients with Acute Myocardial Infarction. The American Journal Of Medicine 2012, 126: 74.e1-74.e9. PMID: 22925314, DOI: 10.1016/j.amjmed.2012.02.025.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionGuidelines-Coronary Artery Disease registryAcute myocardial infarction treatmentAdherence modelCertain high-risk populationsGuideline-recommended therapiesLogistic multivariable regression modelsHigh-risk populationGuideline-based carePredictors of adherenceQuality improvement interventionsMultivariable regression modelsMyocardial infarction treatmentEligible patientsHospital characteristicsWorse adherenceSummary scoresDisease RegistryInfarction treatmentPatientsImprovement interventionsGreater adherenceInfarctionAdherence
2011
Regional differences in clinical profile, quality of care, and outcomes among Hispanic patients hospitalized with acute myocardial infarction in the Get with Guidelines–Coronary Artery Disease (GWTG-CAD) Registry
Krim S, Vivo R, Krim N, Cox M, Hernandez A, Peterson E, Fonarow G, Piña I, Schwamm L, Bhatt D. Regional differences in clinical profile, quality of care, and outcomes among Hispanic patients hospitalized with acute myocardial infarction in the Get with Guidelines–Coronary Artery Disease (GWTG-CAD) Registry. American Heart Journal 2011, 162: 988-995.e4. PMID: 22137071, DOI: 10.1016/j.ahj.2011.09.006.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionHispanic patientsQuality of careHospital mortalityClinical profileEnzyme inhibitors/angiotensin receptor blockersGuidelines-Coronary Artery Disease registryGuideline-recommended therapiesAngiotensin receptor blockersLipid-lowering therapyLonger hospital stayHigh rateHospital outcomesHospital stayReceptor blockersClinical characteristicsMale predominanceThrombolysis timeΒ-blockersRegional differencesDisease RegistryPatientsInfarctionHispanicsPrediction of Early Stroke Risk in Transient Symptoms With Infarction
Arsava E, Furie K, Schwamm L, Sorensen A, Ay H. Prediction of Early Stroke Risk in Transient Symptoms With Infarction. Stroke 2011, 42: 2186-2190. PMID: 21680907, PMCID: PMC3144273, DOI: 10.1161/strokeaha.110.604280.Peer-Reviewed Original ResearchConceptsTransient ischemic attackReceiver-operating characteristic curveIschemic attackStroke riskTransient symptomsDiffusion-weighted imagesStroke prevention strategiesHigh-risk patientsRisk of strokeEarly stroke riskCharacteristic curveNew infarctionRecurrent strokeClinical deteriorationConsecutive patientsIschemic strokeSymptom onsetIndex lesionRetrospective seriesPrevention strategiesPatientsEarly interventionInfarctionStrokeSubsequent strokeQUALITY OF CARE AND OUTCOMES AMONG PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND CHRONIC RENAL INSUFFICIENCY: REPORT FROM THE GET WITH THE GUIDELINES PROGRAM
Vasaiwala S, Cannon C, Fonarow G, Peacock F, Laskey W, Schwamm L, Liang L, Hernandez A, Peterson E, Bhatt D. QUALITY OF CARE AND OUTCOMES AMONG PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND CHRONIC RENAL INSUFFICIENCY: REPORT FROM THE GET WITH THE GUIDELINES PROGRAM. Journal Of The American College Of Cardiology 2011, 57: e1029. DOI: 10.1016/s0735-1097(11)61029-2.Peer-Reviewed Original ResearchREGIONAL DIFFERENCES IN CLINICAL PROFILE, QUALITY OF CARE AND OUTCOMES AMONG HISPANIC PATIENTS HOSPITALIZED WITH ACUTE MYOCARDIAL INFARCTION IN THE GET WITH GUIDELINES-CORONARY ARTERY DISEASE REGISTRY
Krim S, Vivo R, Krim N, Cox M, Hernandez A, Peterson E, Fonarow G, Piña I, Schwamm L, Bhatt D. REGIONAL DIFFERENCES IN CLINICAL PROFILE, QUALITY OF CARE AND OUTCOMES AMONG HISPANIC PATIENTS HOSPITALIZED WITH ACUTE MYOCARDIAL INFARCTION IN THE GET WITH GUIDELINES-CORONARY ARTERY DISEASE REGISTRY. Journal Of The American College Of Cardiology 2011, 57: e1162. DOI: 10.1016/s0735-1097(11)61162-5.Peer-Reviewed Original ResearchQUALITY OF CARE AND OUTCOMES IN 5,339 PATIENTS AGED 80 OR ABOVE PRESENTING WITH ST-ELEVATION MYOCARDIAL INFARCTION: ANALYSIS FROM AMERICAN HEART ASSOCIATION GET WITH THE GUIDELINES: CORONARY ARTERY DISEASE
Medina H, Cannon C, Fonarow G, Peacock F, Laskey W, Grau-Sepulveda M, Fernandez A, Peterson E, Schwamm L, Bhatt D. QUALITY OF CARE AND OUTCOMES IN 5,339 PATIENTS AGED 80 OR ABOVE PRESENTING WITH ST-ELEVATION MYOCARDIAL INFARCTION: ANALYSIS FROM AMERICAN HEART ASSOCIATION GET WITH THE GUIDELINES: CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2011, 57: e1285. DOI: 10.1016/s0735-1097(11)61285-0.Peer-Reviewed Original Research
2010
Causes of Ischemic Stroke
Silva G, Koroshetz W, González R, Schwamm L. Causes of Ischemic Stroke. 2010, 25-42. DOI: 10.1007/978-3-642-12751-9_2.Peer-Reviewed Original ResearchIschemic strokeCryptogenic strokeSmall infarctionClinical workupMajor disabilityClinical signsDefinite causeUnknown causeHeterogeneous diseaseLacunar mechanismPathologic processesLarge seriesStrokeOrgan systemsGroups of strokesReporting systemCauseBrainInfarctionIschemiaPatientsMajorityWorkupDisease
2009
Hospital performance recognition with the Get With The Guidelines Program and mortality for acute myocardial infarction and heart failure
Heidenreich P, Lewis W, LaBresh K, Schwamm L, Fonarow G. Hospital performance recognition with the Get With The Guidelines Program and mortality for acute myocardial infarction and heart failure. American Heart Journal 2009, 158: 546-553. PMID: 19781413, DOI: 10.1016/j.ahj.2009.07.031.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHeart failureMyocardial infarctionProcess of careAdditional adjustmentGuideline programHeart failure mortalityRisk-adjusted mortalityAmerican Heart AssociationAcute myocardial infractionMI mortalityHeart AssociationHospital characteristicsMyocardial infractionLower riskHospitalMortalityMedicaid ServicesCareHigh levelsInfarctionCardiac processesMedicareFailureGWTG
2006
Transient ischemic attack with infarction: A unique syndrome?
Ay H, Koroshetz W, Benner T, Vangel M, Wu O, Schwamm L, Sorensen A. Transient ischemic attack with infarction: A unique syndrome? International Congress Series 2006, 1290: 45-55. DOI: 10.1016/j.ics.2006.04.007.Peer-Reviewed Original ResearchTransient ischemic attackIschemic strokeIschemic attackSymptom durationDistinct prognostic featuresSeparate clinical syndromesRecurrent ischemic strokeMinor ischemic strokeUnderwent diffusion-weighted imagingDiffusion-weighted imagingInfarct volumeConsecutive patientsTIA ratePrognostic featuresTransient symptomsBrain syndromeClinical syndromeUnique syndromeInfarctionPatientsStrokeSyndromeSymptomsDurationInfarcts
2005
The Evolving Role of Acute Stroke Imaging in Intravenous Thrombolytic Therapy: Patient Selection and Outcomes Assessment
Sims J, Schwamm L. The Evolving Role of Acute Stroke Imaging in Intravenous Thrombolytic Therapy: Patient Selection and Outcomes Assessment. Neuroimaging Clinics Of North America 2005, 15: 421-440. PMID: 16198950, DOI: 10.1016/j.nic.2005.06.001.Peer-Reviewed Original ResearchConceptsPatient selectionIntravenous thrombolytic therapyStroke pathophysiologyThrombolytic trialsPenumbral tissueAcute strokeLarge infarctionCerebral ischemiaRisk stratificationThrombolytic therapyCT perfusionStroke mechanismBrain hemorrhageTherapeutic successCT angiographyUnenhanced CTOutcome assessmentPotential future roleEarly signsEarly trialsMR imagingThrombolysisInfarctionTrialsEvolving roleTransient ischemic attack with infarction: A unique syndrome?
Ay H, Koroshetz W, Benner T, Vangel M, Wu O, Schwamm L, Sorensen A. Transient ischemic attack with infarction: A unique syndrome? Annals Of Neurology 2005, 57: 679-686. PMID: 15852402, DOI: 10.1002/ana.20465.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic strokeIschemic attackSymptom durationDistinct prognostic featuresSeparate clinical syndromesRecurrent ischemic strokeMinor ischemic strokeUnderwent diffusion-weighted imagingDiffusion-weighted imagingInfarct volumeConsecutive patientsTIA ratePrognostic featuresTransient symptomsBrain syndromeClinical syndromeUnique syndromeInfarctionPatientsStrokeSyndromeSymptomsDurationInfarcts
2004
Characterization and evolution of diffusion MR imaging abnormalities in stroke patients undergoing intra-arterial thrombolysis.
Schaefer P, Hassankhani A, Putman C, Sorensen A, Schwamm L, Koroshetz W, Gonzalez R. Characterization and evolution of diffusion MR imaging abnormalities in stroke patients undergoing intra-arterial thrombolysis. American Journal Of Neuroradiology 2004, 25: 951-7. PMID: 15205129, PMCID: PMC7975652.Peer-Reviewed Original ResearchConceptsIntra-arterial thrombolysisDiffusion-weighted imagingDWI findingsDWI ratioADC ratioReperfusion therapyAcute strokeApparent diffusion coefficientInitial diffusion-weighted imagingPretreatment diffusion-weighted imagingADC valuesRespective mean changesEventual infarctionAcute occlusionAnterior circulationStroke patientsLesion volumeMean changePatientsThrombolysisLesion growthMR imagingTissue viabilityLesionsInfarction
2003
Whole-Brain CT Perfusion Measurement of Perfused Cerebral Blood Volume in Acute Ischemic Stroke: Probability Curve for Regional Infarction
Hunter G, Silvennoinen H, Hamberg L, Koroshetz W, Buonanno F, Schwamm L, Rordorf G, Gonzalez R. Whole-Brain CT Perfusion Measurement of Perfused Cerebral Blood Volume in Acute Ischemic Stroke: Probability Curve for Regional Infarction. Radiology 2003, 227: 725-30. PMID: 12728181, DOI: 10.1148/radiol.2273012169.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeCerebral blood volumeIschemic strokeBlood volumeMajor arterial occlusionLikelihood of infarctionLogistic regression analysisPositive predictive valueCT perfusion measurementsAcute strokeCerebral infarctionArterial occlusionIntracranial hemorrhagePerfusion scanCore infarctionPCBVInfarctionPositive followProbability of survivalRegional infarctionPredictive valuePatientsStrokePerfusion measurementsRegression analysis
2002
Anatomy of Stroke, Part I
Caviness V, Makris N, Montinaro E, Sahin N, Bates J, Schwamm L, Caplan D, Kennedy D. Anatomy of Stroke, Part I. Stroke 2002, 33: 2549-2556. PMID: 12411641, DOI: 10.1161/01.str.0000036083.90045.08.Peer-Reviewed Original ResearchConceptsMCA territoryVolumetric analysisDistribution of infarctsTopography of infarctionTreatment of strokePerfusion-weighted imagingCorrelation of outcomesEmbolic strokeAcute eventClinical correlatesUnderlying pathophysiologyVascular territoriesLesion volumeStroke lesionsClinical diagnosisStrokeTherapeutic agentsMRINeuroanatomic structuresInfarctsTopographic patternsInvolvementPotential benefitsPerfusion compartmentsInfarction‘Footprints’ of Transient Ischemic Attacks: A Diffusion-Weighted MRI Study
Ay H, Oliveira-Filho J, Buonanno F, Schaefer P, Furie K, Chang Y, Rordorf G, Schwamm L, Gonzalez R, Koroshetz W. ‘Footprints’ of Transient Ischemic Attacks: A Diffusion-Weighted MRI Study. Cerebrovascular Diseases 2002, 14: 177-186. PMID: 12403950, DOI: 10.1159/000065682.Peer-Reviewed Original ResearchConceptsTransient ischemic attackFast fluid attenuated inversion recoveryDiffusion-weighted imagingIschemic attackDWI lesionsFocal neurologic symptomsHalf of patientsDiffusion-weighted MRI studiesFluid attenuated inversion recoveryAttenuated inversion recoveryBrain infarctionClinical characteristicsNeurologic symptomsConsecutive patientsIndependent predictorsIschemic injuryMotor symptomsRecent infarctionCerebrovascular abnormalitiesClinical syndromeVascular territoriesStroke mechanismMRI studiesPatientsInfarction
1996
Hyperacute stroke: evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging.
Sorensen A, Buonanno F, Gonzalez R, Schwamm L, Lev M, Huang-Hellinger F, Reese T, Weisskoff R, Davis T, Suwanwela N, Can U, Moreira J, Copen W, Look R, Finklestein S, Rosen B, Koroshetz W. Hyperacute stroke: evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging. Radiology 1996, 199: 391-401. PMID: 8668784, DOI: 10.1148/radiology.199.2.8668784.Peer-Reviewed Original ResearchConceptsInfarct volumeNormal findingsHyperacute cerebral ischemiaMagnetic resonance imagingEcho-planar MR imagingAcute hemiparesisAcute strokeCerebral ischemiaInitial CTMR imaging techniquesStroke diagnosisPatientsResonance imagingSubsequent imagingMR imagingAbnormalitiesConventional MRCTImaging techniquesImagingMRHoursFindingsHemiparesisInfarction