2024
COVID‐19 Infection Is Associated With Poor Outcomes in Patients With Intracerebral Hemorrhage
Renedo D, Leasure A, Young R, Rivier C, Alhanti B, Mac Grory B, Messe S, Reeves M, Hassan A, Schwamm L, de Havenon A, Matouk C, Sheth K, Falcone G. COVID‐19 Infection Is Associated With Poor Outcomes in Patients With Intracerebral Hemorrhage. Journal Of The American Heart Association 2024, 13: e030999. PMID: 38293940, PMCID: PMC11056169, DOI: 10.1161/jaha.123.030999.Peer-Reviewed Original ResearchConceptsOdds of poor outcomeIntracerebral hemorrhageCOVID-19 infectionPoor outcomeHealth care deliverySkilled nursing facilityMultivariate analysisOdds of mortalityConcomitant COVID-19 infectionAssociated with poor outcomesCare deliveryNursing facilitiesPoor functional outcomeCOVID-19OddsICH outcomeImpact of COVID-19No significant differenceObservational studyHemorrhagic strokeWorsen outcomesPatient populationFunctional outcomesStroke dataPatients
2020
Cerebral Small Vessel Diseases and Sleep Related Strokes
Lauer A, Ay H, Bianchi M, Charidimou A, Boulouis G, Ayres A, Vashkevich A, Schwab K, Singhal A, Viswanathan A, Rost N, Goldstein J, Rosand J, Schwamm L, Greenberg S, Gurol M. Cerebral Small Vessel Diseases and Sleep Related Strokes. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 104606. PMID: 31937490, DOI: 10.1016/j.jstrokecerebrovasdis.2019.104606.Peer-Reviewed Original ResearchConceptsSmall vessel diseaseCerebral small vessel diseaseSmall artery occlusionIntracerebral hemorrhageIschemic strokeHemorrhagic strokeICH patientsVessel diseasePresence of SVDCerebral amyloid angiopathyLobar intracerebral hemorrhageICH cohortArtery occlusionSymptom onsetAmyloid angiopathyHemodynamic changesIS cohortRisk factorsStroke systemsCausative ClassificationStrokePatientsCohortDeep locationDisease
2018
Incidence of Atrial Fibrillation in Patients With Recent Ischemic Stroke Versus Matched Controls
Witsch J, Merkler AE, Chen ML, Navi BB, Sheth KN, Freedman B, Schwamm LH, Kamel H. Incidence of Atrial Fibrillation in Patients With Recent Ischemic Stroke Versus Matched Controls. Stroke 2018, 49: 2529-2531. PMID: 30355110, PMCID: PMC6205716, DOI: 10.1161/strokeaha.118.022826.Peer-Reviewed Original ResearchConceptsAtrial fibrillation/flutterIschemic strokeHemorrhagic strokeAF incidenceAF diagnosisRisk factorsAF-free patientsNew AF diagnosisVascular risk factorsNonstroke diagnosisAutonomic dysfunctionCharlson comorbidityStroke cohortAtrial fibrillationCox regressionNinth RevisionOutpatient claimsIncidental findingClinical ModificationHigh riskInternational ClassificationMedicare beneficiariesSurvival statisticsMatched ControlsPatients
2017
American Telemedicine Association: Telestroke Guidelines
Demaerschalk BM, Berg J, Chong BW, Gross H, Nystrom K, Adeoye O, Schwamm L, Wechsler L, Whitchurch S. American Telemedicine Association: Telestroke Guidelines. Telemedicine Journal And E-Health 2017, 23: 376-389. PMID: 28384077, PMCID: PMC5802246, DOI: 10.1089/tmj.2017.0006.Peer-Reviewed Original ResearchConceptsAcute stroke syndromeStroke patient careAcute care facilitiesTelestroke modelStroke syndromeHemorrhagic strokeNeurologic emergencyAcute phaseHospital encountersNeurological emergencyStroke careTelestroke servicesCare facilitiesClinical practiceClinical protocolsPatient careClinical servicesRemote careHealthcare practitionersCarePatientsStrokeQuality outcomesEntire continuumGuidelines
2015
Increased Risk of Cerebrovascular Disease Among Patients With Neurofibromatosis Type 1
Terry A, Jordan J, Schwamm L, Plotkin S. Increased Risk of Cerebrovascular Disease Among Patients With Neurofibromatosis Type 1. Stroke 2015, 47: 60-65. PMID: 26645253, DOI: 10.1161/strokeaha.115.011406.Peer-Reviewed Original ResearchConceptsNeurofibromatosis type 1Ischemic strokeIntracerebral hemorrhageGeneral populationCases of NF1US Nationwide Inpatient SampleType 1Hemorrhagic stroke typesNew neurological symptomsStroke risk factorsRisk of strokeOdds of strokeTime of strokeNationwide Inpatient SampleMultivariable logistic regressionCase-control studyType of strokeYounger mean ageAdult patientsPediatric patientsHemorrhagic strokeNeurological symptomsCerebrovascular diseaseMean ageInpatient SamplePatient Characteristics and Outcomes After Hemorrhagic Stroke in Pregnancy
Leffert LR, Clancy CR, Bateman BT, Cox M, Schulte PJ, Smith EE, Fonarow GC, Schwamm LH, Kuklina EV, George MG. Patient Characteristics and Outcomes After Hemorrhagic Stroke in Pregnancy. Circulation Cardiovascular Quality And Outcomes 2015, 8: s170-s178. PMID: 26515206, DOI: 10.1161/circoutcomes.115.002242.Peer-Reviewed Original ResearchConceptsStroke risk factorsSubarachnoid hemorrhage patientsHemorrhagic strokeRisk factorsHS patientsHospital mortalityHemorrhage patientsDiseases-Ninth Revision codesBlood pressure criteriaGuidelines-Stroke registryPregnancy-related strokeAssociation of pregnancyNonpregnant female patientsConditional logistic regressionFisher's exact testWilcoxon rank sum testRank sum testGuidelines-StrokeSevere preeclampsiaHome dischargeIschemic strokeNonpregnant womenPatient characteristicsRisk patientsIndependent ambulationClinical Effectiveness of Statin Therapy After Ischemic Stroke: Primary Results From the Statin Therapeutic Area of the Patient‐Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study
O'Brien E, Greiner M, Xian Y, Fonarow G, Olson D, Schwamm L, Bhatt D, Smith E, Maisch L, Hannah D, Lindholm B, Peterson E, Pencina M, Hernandez A. Clinical Effectiveness of Statin Therapy After Ischemic Stroke: Primary Results From the Statin Therapeutic Area of the Patient‐Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study. Circulation 2015, 132: 1404-1413. PMID: 26246175, DOI: 10.1161/circulationaha.115.016183.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaCardiovascular DiseasesDose-Response Relationship, DrugFemaleFollow-Up StudiesHospitalizationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMedicaidMedical RecordsMedicarePatient DischargePatient Outcome AssessmentPatient ReadmissionRecurrenceRegistriesTreatment OutcomeUnited StatesConceptsMajor adverse cardiovascular eventsAdverse cardiovascular eventsStatin therapyTime of admissionCardiovascular eventsIschemic strokePatient prefersCause mortalityHemorrhagic strokeOlder ischemic stroke patientsGuidelines-Stroke registryHigh-intensity doseIschemic stroke patientsModerate-intensity statinsPatient-centered outcomesReal-world effectivenessYears of ageOutcomes Research InstituteEffectiveness researchCoprimary outcomesCardiovascular readmissionCause readmissionSecondary outcomesStroke patientsClinical effectivenessContemporary Trends and Predictors of Postacute Service Use and Routine Discharge Home After Stroke
Bettger J, McCoy L, Smith E, Fonarow G, Schwamm L, Peterson E. Contemporary Trends and Predictors of Postacute Service Use and Routine Discharge Home After Stroke. Journal Of The American Heart Association 2015, 4: e001038. PMID: 25713291, PMCID: PMC4345857, DOI: 10.1161/jaha.114.001038.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrain IschemiaFemaleHome Health NursingHospitalizationHumansIntracranial HemorrhagesLength of StayMaleMiddle AgedMultivariate AnalysisPatient DischargeRecovery of FunctionRehabilitation CentersRisk FactorsSelf CareSkilled Nursing FacilitiesStrokeStroke RehabilitationTreatment OutcomeWalkingConceptsInpatient rehabilitation facilityPAC useSkilled nursing facilitiesHome healthStroke patientsService useHealth insurance typeHospital discharge dispositionStrongest clinical predictorsYears of agePostacute care servicesGuidelines-StrokeDischarge homeHospital stayDischarge dispositionClinical predictorsHemorrhagic strokeOral intakeDysphagia screenMultivariable analysisAcute careStroke hospitalizationsInsurance typeSNF useNursing facilities
2013
Patterns of Emergency Medical Services Use and Its Association With Timely Stroke Treatment
Ekundayo O, Saver J, Fonarow G, Schwamm L, Xian Y, Zhao X, Hernandez A, Peterson E, Cheng E. Patterns of Emergency Medical Services Use and Its Association With Timely Stroke Treatment. Circulation Cardiovascular Quality And Outcomes 2013, 6: 262-269. PMID: 23633218, DOI: 10.1161/circoutcomes.113.000089.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overChi-Square DistributionEmergency Medical ServicesEmergency Service, HospitalEthnicityFemaleGuideline AdherenceHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedMinority GroupsOdds RatioOutcome and Process Assessment, Health CarePatient Acceptance of Health CarePatient Education as TopicPractice Guidelines as TopicRegistriesRisk FactorsStrokeTime FactorsTime-to-TreatmentTransportation of PatientsTreatment OutcomeUnited StatesConceptsEmergency medical servicesStroke patientsEMS useEmergency medical services useMinority raceHealth Stroke ScoreMedical service useTreatment of strokeTissue-type plasminogen activatorEligible patientsGuidelines-StrokeSevere strokeStroke ScoreHospital arrivalOlder patientsYounger patientsHemorrhagic strokeStroke treatmentMedicare insuranceInsurance statusEMS activationDecreased oddsEMS transportService usePatientsA Risk Score for In‐Hospital Death in Patients Admitted With Ischemic or Hemorrhagic Stroke
Smith E, Shobha N, Dai D, Olson D, Reeves M, Saver J, Hernandez A, Peterson E, Fonarow G, Schwamm L. A Risk Score for In‐Hospital Death in Patients Admitted With Ischemic or Hemorrhagic Stroke. Journal Of The American Heart Association 2013, 2: e005207. PMID: 23525444, PMCID: PMC3603253, DOI: 10.1161/jaha.112.005207.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaCerebral HemorrhageChi-Square DistributionDecision Support TechniquesFemaleHospital MortalityHumansInpatientsLogistic ModelsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsRegistriesReproducibility of ResultsRisk AssessmentRisk FactorsSeverity of Illness IndexStrokeSubarachnoid HemorrhageUnited StatesConceptsStroke typeIschemic strokeIntracerebral hemorrhageRisk scoreGuidelines-Stroke databaseHealth Stroke ScaleIn-Hospital DeathRisk of deathHospital mortalityHospital deathStroke ScaleStroke admissionsIndependent predictorsHemorrhagic strokeStroke patientsC-statisticSingle risk scoreOverall populationLogistic regressionPatientsValidation sampleMortalityDeathPoint scorePrediction score
2010
Patterns and Predictors of Discharge Statin Prescription Among Hospitalized Patients With Intracerebral Hemorrhage
Ovbiagele B, Schwamm L, Smith E, Hernandez A, Olson D, Pan W, Fonarow G, Saver J. Patterns and Predictors of Discharge Statin Prescription Among Hospitalized Patients With Intracerebral Hemorrhage. Stroke 2010, 41: 2271-2277. PMID: 20724709, DOI: 10.1161/strokeaha.110.593228.Peer-Reviewed Original ResearchConceptsDischarge statin prescriptionStatin prescriptionIntracerebral hemorrhageStatin useStatin treatmentPrior stroke/transient ischemic attackStroke/transient ischemic attackCholesterol Levels (SPARCL) trialStatin treatment armsLogistic multivariable regression modelsTransient ischemic attackHemorrhagic stroke riskHigher future riskMultivariable regression modelsGuidelines-StrokeIschemic attackEligible patientsStroke preventionIschemic eventsStroke riskHospitalized patientsHemorrhagic strokeTreatment armsMean ageFemale sex
2009
Influence of stroke subtype on quality of care in the Get With The Guidelines–Stroke Program
Smith E, Liang L, Hernandez A, Reeves M, Cannon C, Fonarow G, Schwamm L. Influence of stroke subtype on quality of care in the Get With The Guidelines–Stroke Program. Neurology 2009, 73: 709-716. PMID: 19720978, PMCID: PMC2734292, DOI: 10.1212/wnl.0b013e3181b59a6e.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCerebral HemorrhageEmergency Medical ServicesFemaleGuideline AdherenceHospitalsHumansMaleMiddle AgedOutcome Assessment, Health CarePractice Guidelines as TopicQuality Assurance, Health CareQuality of Health CareRisk Reduction BehaviorSmoking CessationStrokeSubarachnoid HemorrhageUnited StatesVenous ThrombosisConceptsQuality of careIS/TIAIntracerebral hemorrhageIschemic strokeStroke subtypesTIA admissionsHemorrhagic strokeCare measuresDeep venous thrombosis preventionHospital-based acute careGuidelines-Stroke databaseGuidelines-Stroke programGWTG-Stroke programVenous thrombosis preventionSmoking cessation therapyMeasures of careLogistic regression modelsDVT preventionIneligible patientsNational GetDysphagia screeningCessation therapySAH patientsAcute careICH patients
2008
Off-Hour Admission and In-Hospital Stroke Case Fatality in the Get With The Guidelines-Stroke Program
Reeves M, Smith E, Fonarow G, Hernandez A, Pan W, Schwamm L. Off-Hour Admission and In-Hospital Stroke Case Fatality in the Get With The Guidelines-Stroke Program. Stroke 2008, 40: 569-576. PMID: 18988914, DOI: 10.1161/strokeaha.108.519355.Peer-Reviewed Original ResearchConceptsHemorrhagic stroke admissionsOff-hour presentationIschemic stroke admissionsQuality of careHospital case fatalityStroke admissionsHospital mortalityHours presentationCase fatalityIschemic strokeHospital case fatality rateGuidelines-Stroke programGWTG-Stroke programHospital-based outcomesAcute ischemic strokeHospital-level factorsStroke case fatalityTime of presentationCase fatality rateEquation logistic regressionQuality improvement effortsStroke ProgramAcute strokeHemorrhagic strokeHours admission