2021
Exploring the Unmet Need in Acute Ischemic Stroke Patients Not Treated With Intravenous Alteplase: The Get With The Guidelines‐Stroke Registry
Mac Grory B, Xian Y, Solomon N, Matsouaka R, Decker‐Palmer M, Fonarow G, Smith E, Schwamm L. Exploring the Unmet Need in Acute Ischemic Stroke Patients Not Treated With Intravenous Alteplase: The Get With The Guidelines‐Stroke Registry. Stroke Vascular And Interventional Neurology 2021, 2 DOI: 10.1161/svin.121.000226.Peer-Reviewed Original ResearchGuidelines-Stroke registryAcute ischemic strokeIschemic strokePatient populationCommon reasonUnmet needAcute ischemic stroke patientsIntravenous tissue plasminogen activatorAcute ischemic stroke careGuidelines-Stroke hospitalsIschemic stroke patientsIschemic stroke careLong-term outcomesTissue plasminogen activatorAlteplase deliveryHospital mortalityIntravenous alteplaseClinical characteristicsConclusions PatientsReadmission ratesEarly administrationPostdischarge costsStroke careStroke patientsFunctional outcome
2020
Association Between Thrombolytic Door-to-Needle Time and 1-Year Mortality and Readmission in Patients With Acute Ischemic Stroke
Man S, Xian Y, Holmes D, Matsouaka R, Saver J, Smith E, Bhatt D, Schwamm L, Fonarow G. Association Between Thrombolytic Door-to-Needle Time and 1-Year Mortality and Readmission in Patients With Acute Ischemic Stroke. JAMA 2020, 323: 2170-2184. PMID: 32484532, PMCID: PMC7267850, DOI: 10.1001/jama.2020.5697.Peer-Reviewed Original ResearchConceptsIntravenous tissue plasminogen activatorAcute ischemic strokeTissue plasminogen activatorCause mortalityNeedle timeCause readmissionIschemic strokeLong-term outcomesShorter doorBetter long-term outcomesImproved long-term outcomesPlasminogen activatorRetrospective cohort studyGood functional outcomeGuidelines-StrokeCohort studyHospital arrivalHospital dischargeMedian doorEarly administrationMedian agePrimary outcomeThrombolytic therapyFunctional outcomeReadmission
2009
Unsuspected coagulopathy rarely prevents IV thrombolysis in acute ischemic strokeSYMBOL
Rost N, Masrur S, Pervez M, Viswanathan A, Schwamm L. Unsuspected coagulopathy rarely prevents IV thrombolysis in acute ischemic strokeSYMBOL. Neurology 2009, 73: 1957-1962. PMID: 19940272, PMCID: PMC4109188, DOI: 10.1212/wnl.0b013e3181c5b46d.Peer-Reviewed Original ResearchConceptsTissue plasminogen activatorEmergency departmentAbsolute contraindicationStroke patientsAmerican Heart Association/American Stroke Association guidelinesAcute ischemic stroke patientsAmerican Stroke Association guidelinesGuidelines-Stroke databaseIschemic stroke patientsCurrent practice guidelinesReferral centerRelative contraindicationThrombolysis patientsEarly administrationRetrospective reviewStroke databaseThrombolytic therapyTreatable factorsDiagnostic neuroimagingAssociation guidelinesClinical evaluationPractice guidelinesBleeding diathesisCoagulopathyPatients