2017
Clinical Imaging Factors Associated With Infarct Progression in Patients With Ischemic Stroke During Transfer for Mechanical Thrombectomy
Boulouis G, Lauer A, Siddiqui A, Charidimou A, Regenhardt R, Viswanathan A, Rost N, Leslie-Mazwi T, Schwamm L. Clinical Imaging Factors Associated With Infarct Progression in Patients With Ischemic Stroke During Transfer for Mechanical Thrombectomy. JAMA Neurology 2017, 74: 1361-1367. PMID: 28973081, PMCID: PMC5710581, DOI: 10.1001/jamaneurol.2017.2149.Peer-Reviewed Original ResearchConceptsThrombectomy-capable stroke centersCollateral blood flowIschemic strokeInfarct progressionMechanical thrombectomyCT angiographyMAIN OUTCOMEVessel statusBlood flowImaging factorsHigher adjusted odds ratioVascular imagingFavorable imaging profileHealth Stroke ScoreAcute ischemic strokeHigher National InstitutesAdjusted odds ratioRegional stroke networkStroke care networksStroke centersStroke ScoreConsecutive patientsStroke NetworkClinical severityFutile transfers
2015
FLAIR Vascular Hyperintensity is a Surrogate of Collateral Flow and Leukoaraiosis in Patients With Acute Stroke Due to Proximal Artery Occlusion
Karadeli H, Giurgiutiu D, Cloonan L, Fitzpatrick K, Kanakis A, Ozcan M, Schwamm L, Rost N. FLAIR Vascular Hyperintensity is a Surrogate of Collateral Flow and Leukoaraiosis in Patients With Acute Stroke Due to Proximal Artery Occlusion. Journal Of Neuroimaging 2015, 26: 219-223. PMID: 26250448, PMCID: PMC4744593, DOI: 10.1111/jon.12274.Peer-Reviewed Original ResearchConceptsProximal artery occlusionCollateral flow gradeFlow gradeAIS patientsWhite matter hyperintensitiesWMH volumeCT angiographyFVH scoreVascular hyperintensityArtery occlusionIntravenous tissue plasminogen activator administrationInversion recovery vascular hyperintensityAcute ischemic stroke patientsTissue plasminogen activator administrationAdmission CT angiographyBaseline CT angiographyCollateral vessel statusFLAIR vascular hyperintensityLeptomeningeal collateral statusMedian WMH volumeSalvageable brain tissueConsecutive AIS patientsIschemic stroke patientsWorse clinical outcomesAcute MRI
2011
CT angiography predicts use of tertiary interventional services in acute ischemic stroke patients
Thomas L, Goldstein J, Hakimelahi R, Chang Y, Yoo A, Schwamm L, Gonzalez R. CT angiography predicts use of tertiary interventional services in acute ischemic stroke patients. International Journal Of Emergency Medicine 2011, 4: 62. PMID: 21967677, PMCID: PMC3203028, DOI: 10.1186/1865-1380-4-62.Peer-Reviewed Original ResearchCerebral artery occlusionProximal cerebral artery occlusionEmergent CT angiographyIschemic stroke patientsCT angiographyProximal occlusionArtery occlusionNegative predictive valuePositive predictive valueIndependent predictorsStroke patientsNeurointerventional servicesInitial NIH Stroke Scale scorePredictive valueConsecutive ischemic stroke patientsAcute ischemic stroke patientsNIH Stroke Scale scoreInterventional servicesMechanical clot retrievalTertiary care interventionsIntra-arterial thrombolysisStroke Scale scoreAcute ischemic strokeTertiary care centerHistorical cohort study
2009
False Positive CT Angiography in Brain Death
Greer DM, Strozyk D, Schwamm LH. False Positive CT Angiography in Brain Death. Neurocritical Care 2009, 11: 272-275. PMID: 19390993, DOI: 10.1007/s12028-009-9220-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain DeathBrain EdemaCerebral AngiographyCerebrovascular CirculationCircle of WillisDiagnosis, DifferentialElectroencephalographyFalse Positive ReactionsFemaleHeart ArrestHumansTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedUltrasonography, Doppler, TranscranialConceptsCerebral circulatory arrestBrain criteriaCirculatory arrestBrain deathPositive CT angiographyCerebral blood flowSingle photon emissionTranscranial DopplerNewer testsClinical examinationTomographic angiographyConventional angiographyCT angiographyBlood flowAncillary testsEase of performanceAngiographyDetermination of deathGold standardConfirmatory testDeathPhoton emissionAcceptable testArrestPatients
2005
The Evolving Role of Acute Stroke Imaging in Intravenous Thrombolytic Therapy: Patient Selection and Outcomes Assessment
Sims J, Schwamm L. The Evolving Role of Acute Stroke Imaging in Intravenous Thrombolytic Therapy: Patient Selection and Outcomes Assessment. Neuroimaging Clinics Of North America 2005, 15: 421-440. PMID: 16198950, DOI: 10.1016/j.nic.2005.06.001.Peer-Reviewed Original ResearchConceptsPatient selectionIntravenous thrombolytic therapyStroke pathophysiologyThrombolytic trialsPenumbral tissueAcute strokeLarge infarctionCerebral ischemiaRisk stratificationThrombolytic therapyCT perfusionStroke mechanismBrain hemorrhageTherapeutic successCT angiographyUnenhanced CTOutcome assessmentPotential future roleEarly signsEarly trialsMR imagingThrombolysisInfarctionTrialsEvolving roleArterial occlusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV tPA treatment.
Sims J, Rordorf G, Smith E, Koroshetz W, Lev M, Buonanno F, Schwamm L. Arterial occlusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV tPA treatment. American Journal Of Neuroradiology 2005, 26: 246-51. PMID: 15709120, PMCID: PMC7974096.Peer-Reviewed Original ResearchConceptsCT angiographyLocation of occlusionEarly improvementInitial NIHSSArterial occlusionIntravenous tissue-type plasminogen activatorNIH stroke scoreProspective stroke databaseHealth Stroke ScaleAcute stroke patientsMiddle cerebral arteryPatent vasculatureSite of occlusionTissue-type plasminogen activatorLower NIHSSStroke ScaleStroke ScoreSymptomatic hemorrhageRankin ScaleAcute outcomesHemorrhagic riskCerebral arteryClinical outcomesStroke databaseStroke patients
2001
CT Angiography Use in Acute Stroke Patients Undergoing i.v. TPA
Rordorf G, Koroshetz W, Buonanno F, McDonald C, Greer D, Ougorets I, Rosand J, Schwamm L. CT Angiography Use in Acute Stroke Patients Undergoing i.v. TPA. Stroke 2001, 32: 370-370. DOI: 10.1161/str.32.suppl_1.370-a.Peer-Reviewed Original ResearchRt-PACT angiographyInitial head CT scanAsymptomatic intracranial hemorrhageInitial NIHSS scoreMajor vessel occlusionStroke Study GroupAcute ischemic strokeAcute stroke patientsRisk of hemorrhageSubgroup of patientsHead CT scanChances of recanalizationMajor intracranial arteriesHelical CT angiographyNIHSS scoreNINDS criteriaLacunar strokeOcclusive lesionsStroke teamSystemic complicationsTOAST criteriaAnterior circulationDistal emboliIschemic stroke
1998
Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results.
Hunter G, Hamberg L, Ponzo J, Huang-Hellinger F, Morris P, Rabinov J, Farkas J, Lev M, Schaefer P, Ogilvy C, Schwamm L, Buonanno F, Koroshetz W, Wolf G, González R. Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results. American Journal Of Neuroradiology 1998, 19: 29-37. PMID: 9432154, PMCID: PMC8337333.Peer-Reviewed Original ResearchConceptsHyperacute strokeFunctional CTIschemic changesEarly clinical resultsCerebral blood volumeContrast-enhanced scansHelical CT techniqueOcclusion of vesselsHyperacute groupCerebral perfusionPBV mapsArterial anatomyPatient populationBrain stemClinical resultsCT angiogramContrast administrationRegional perfusionCT angiographyBlood volumePatientsPBV valuesWhite matterGray matterClinical feasibility