2019
Teleneurology Consultations for Prognostication and Brain Death Diagnosis
Girkar U, Palacios R, Gupta A, Schwamm L, Singla P, May H, Estrada J, Whitney C, Matiello M. Teleneurology Consultations for Prognostication and Brain Death Diagnosis. Telemedicine Journal And E-Health 2019, 26: 482-486. PMID: 31503539, DOI: 10.1089/tmj.2019.0033.Peer-Reviewed Original ResearchConceptsBrain deathNeurology consultationIntensive care unitBrain death diagnosisPresence of apneaGood inter-rater reliabilityNeurologic prognosisTeleneurology consultationsApnea testingBrainstem reflexesCare unitNeurologic examinationBedside teamCardiac arrestBrain injuryComatose stateInter-rater reliabilityDeath diagnosisConsensus criteriaAmerican AcademyRemote neurologistDiagnosisDeathStandardized scalesConsultation
2010
Clinical Management of Acute Stroke
Rost N, Koroshetz W, González R, Schwamm L. Clinical Management of Acute Stroke. 2010, 211-220. DOI: 10.1007/978-3-642-12751-9_10.Peer-Reviewed Original ResearchAcute strokeStroke patientsPermanent brain injurySerious permanent disabilityAcute stroke managementAcute stroke treatmentMin of presentationLocal clinical pathwayNeurologic dysfunctionStroke treatmentBlood testsStroke managementConsensus guidelinesPhysical examinationClinical managementBrain injuryPermanent disabilityClinical pathwayTreatment decisionsMedical attentionCT interpretationStrokeFirst hourPatientsScan completion
2009
Feasibility of NIRS in the Neurointensive Care Unit: A Pilot Study in Stroke Using Physiological Oscillations
Muehlschlegel S, Selb J, Patel M, Diamond S, Franceschini M, Sorensen A, Boas D, Schwamm L. Feasibility of NIRS in the Neurointensive Care Unit: A Pilot Study in Stroke Using Physiological Oscillations. Neurocritical Care 2009, 11: 288. PMID: 19649749, PMCID: PMC2782535, DOI: 10.1007/s12028-009-9254-4.Peer-Reviewed Original ResearchConceptsCare unitStroke patientsPhysiological oscillationsHemoglobin concentrationMicrovascular hemodynamicsPilot studyIschemic brain injuryNeurointensive care unitNeurocritical care unitPre-hospital settingRespiratory oscillationsWarrants further validationAbsolute hemoglobin concentrationResultsNine patientsCerebral perfusionHemispheric strokeBrain injuryHealthy controlsFuture clinical applicationsPatientsOwn controlClinical feasibilityBedside modalityContinuous-wave NIRSClinical application
2004
Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury.
Huisman T, Schwamm L, Schaefer P, Koroshetz W, Shetty-Alva N, Ozsunar Y, Wu O, Sorensen A. Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. American Journal Of Neuroradiology 2004, 25: 370-6. PMID: 15037457, PMCID: PMC8158566.Peer-Reviewed Original ResearchConceptsGlasgow Coma ScaleDiffusion tensor imagingTraumatic brain injuryRankin scoreInternal capsuleApparent diffusion coefficientADC valuesFA valuesWhite matter injuryHealthy control subjectsDiffuse axonal injuryCorresponding ADC valuesFractional anisotropy valuesNew MR imaging techniquesTBI correlatesComa ScaleClinical scoresAxonal injuryControl subjectsBrain injuryClinical markersMR imaging techniquesTissue injuryBrain ultrastructureWhite matter
2001
Diagnostic Value of Apparent Diffusion Coefficient Hyperintensity in Selected Patients With Acute Neurologic Deficits
Schaefer P, Gonzalez R, Hunter G, Wang B, Koroshetz W, Schwamm L. Diagnostic Value of Apparent Diffusion Coefficient Hyperintensity in Selected Patients With Acute Neurologic Deficits. Journal Of Neuroimaging 2001, 11: 369-380. PMID: 11677876, DOI: 10.1111/j.1552-6569.2001.tb00065.x.Peer-Reviewed Original ResearchConceptsAcute neurologic deficitsMagnetic resonance imagingDiffusion-weighted imagingNeurologic deficitsMRI abnormalitiesClinical syndromeMRI T2 hyperintensityVenous sinus thrombosisIschemic brain injuryEvaluation of patientsSubset of patientsConventional magnetic resonance imagingApparent diffusion coefficient (ADC) mapsDiffusion coefficient mapsHIV encephalopathyHypertensive encephalopathyNonischemic etiologyPosterior leukoencephalopathySinus thrombosisCarotid endarterectomyT2 hyperintensityNeurologic conditionsVasogenic edemaBrain injuryDiffusion magnetic resonance imagingFever in subarachnoid hemorrhage
Oliveira–Filho J, Ezzeddine M, Segal A, Buonanno F, Chang Y, Ogilvy C, Rordorf G, Schwamm L, Koroshetz W, McDonald C. Fever in subarachnoid hemorrhage. Neurology 2001, 56: 1299-1304. PMID: 11376177, DOI: 10.1212/wnl.56.10.1299.Peer-Reviewed Original ResearchConceptsSubarachnoid hemorrhagePoor outcomeTranscranial DopplerNeurologic intensive care unitOlder ageDaily transcranial DopplerGlasgow Coma ScoreHunt-Hess gradeRankin Scale scoreCause of feverIntensive care unitPresence of infectionNontraumatic subarachnoid hemorrhageSymptomatic vasospasmCerebral ischemiaComa ScoreConsecutive patientsAngiographic criteriaCare unitBrain injuryHemorrhage severityVasospasmPatientsFeverScale scoreManagement of Brain Edema Complicating Stroke
Rosand J, Schwamm L. Management of Brain Edema Complicating Stroke. Journal Of Intensive Care Medicine 2001, 16: 128-141. DOI: 10.1046/j.1525-1489.2001.00128.x.Peer-Reviewed Original ResearchCerebral blood flowSecondary brain injuryBrain edemaMagnetic resonance imagingBrain parenchymaVasogenic edemaBrain injuryBlood-brain barrier integrityGlobal cerebral blood flowIschemic brain swellingLocal tissue dysfunctionSerial Neurologic AssessmentIschemic brain edemaOnset of symptomsIntracranial blood volumeIschemic cell injuryResult of injurySpecific MRI sequencesAccumulation of fluidDiffusion-weighted imagingRheologic agentsNeurologic deteriorationBrain swellingDecompressive surgeryIschemic strokeManagement of Brain Edema Complicating Stroke
Rosand J, Schwamm L. Management of Brain Edema Complicating Stroke. Journal Of Intensive Care Medicine 2001, 16: 128-141. DOI: 10.1177/088506660101600303.Peer-Reviewed Original ResearchCerebral blood flowSecondary brain injuryBrain edemaMagnetic resonance imagingBrain parenchymaVasogenic edemaBrain injuryBlood-brain barrier integrityGlobal cerebral blood flowIschemic brain swellingLocal tissue dysfunctionSerial Neurologic AssessmentIschemic brain edemaOnset of symptomsIntracranial blood volumeIschemic cell injuryResult of injurySpecific MRI sequencesAccumulation of fluidDiffusion-weighted imagingRheologic agentsNeurologic deteriorationBrain swellingDecompressive surgeryIschemic stroke
1999
Normal diffusion-weighted MRI during stroke-like deficits
Ay H, Buonanno F, Rordorf G, Schaefer P, Schwamm L, Wu O, Gonzalez R, Yamada K, Sorensen G, Koroshetz W. Normal diffusion-weighted MRI during stroke-like deficits. Neurology 1999, 52: 1784-1792. PMID: 10371524, DOI: 10.1212/wnl.52.9.1784.Peer-Reviewed Original ResearchConceptsDiffusion-weighted MRICerebral ischemic eventsDWI abnormalitiesStroke mimicsIschemic eventsAcute ischemic strokeIschemic brain injuryTransient global amnesiaIschemic causePathophysiologic diagnosisLacunar syndromeNonischemic causesIschemic strokeLacunar infarctionNeurologic deficitsBrain ischemiaConsecutive patientsSuch patientsRadiologic dataFinal diagnosisBrain injuryCortical syndromesFunctional disordersEarly diagnosisGlobal amnesia
1998
Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke
Polidori M, Frei B, Cherubini A, Nelles G, Rordorf G, Keaney J, Schwamm L, Mecocci P, Koroshetz W, Beal M. Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke. Free Radical Biology And Medicine 1998, 25: 561-567. PMID: 9741593, DOI: 10.1016/s0891-5849(98)00085-9.Peer-Reviewed Original ResearchConceptsIschemic brain injuryCerebral syndromeCortical strokePlasma levelsBrain injuryOxidative stressGlasgow Coma ScaleNIH Stroke ScaleLipid hydroperoxidesStroke ScaleIschemic strokeComa ScaleLacunar infarctsStroke volumeMRI scansPatientsTherapeutic interventionsDay 5Significant negative correlationSignificant positive correlationSyndromeStrokeAscorbic acid concentrationInjuryPositive correlation