2017
Multiparametric Magnetic Resonance Imaging for Prediction of Parenchymal Hemorrhage in Acute Ischemic Stroke After Reperfusion Therapy
Nael K, Knitter J, Jahan R, Gornbein J, Ajani Z, Feng L, Meyer B, Schwamm L, Yoo A, Marshall R, Meyers P, Yavagal D, Wintermark M, Liebeskind D, Guzy J, Starkman S, Saver J, Kidwell C. Multiparametric Magnetic Resonance Imaging for Prediction of Parenchymal Hemorrhage in Acute Ischemic Stroke After Reperfusion Therapy. Stroke 2017, 48: 664-670. PMID: 28138001, PMCID: PMC5325250, DOI: 10.1161/strokeaha.116.014343.Peer-Reviewed Original ResearchConceptsCerebral blood volumeAcute ischemic strokeParenchymal hemorrhageReperfusion therapyIschemic strokeReceiver-operating characteristic curve analysisApparent diffusion coefficientMultiparametric magnetic resonance imagingPretreatment magnetic resonanceMagnetic resonance perfusionValues of CBVCharacteristic curve analysisApparent diffusion coefficient (ADC) valuesMagnetic resonance imagingIndependent predictorsIschemic coreRisk stratificationUnivariate analysisClinical trialsMicrovascular permeabilityBlood volumeInfarction corePatientsResonance imagingDiagnostic accuracy
2008
Quantitative Assessment of Core/Penumbra Mismatch in Acute Stroke
Schaefer P, Barak E, Kamalian S, Gharai L, Schwamm L, Gonzalez R, Lev M. Quantitative Assessment of Core/Penumbra Mismatch in Acute Stroke. Stroke 2008, 39: 2986-2992. PMID: 18723425, DOI: 10.1161/strokeaha.107.513358.Peer-Reviewed Original ResearchConceptsCT perfusionPatient selectionInfarct coreAcute middle cerebral artery strokeMiddle cerebral artery strokePreferred imaging methodStroke clinical trialsAcute strokeArtery strokeStroke trialsTrial enrollmentClinical trialsLesion volumeMR perfusionIschemic regionBlood volumeTime abnormalitiesVolume thresholdLesion sizeQuantitative CTPerfusionAdvanced MRCT coverageLesionsMR diffusion
2006
First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy.
Schaefer P, Roccatagliata L, Ledezma C, Hoh B, Schwamm L, Koroshetz W, Gonzalez R, Lev M. First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy. American Journal Of Neuroradiology 2006, 27: 20-5. PMID: 16418350, PMCID: PMC7976067.Peer-Reviewed Original ResearchConceptsCerebral blood volumeAcute stroke patientsCT perfusionStroke patientsCBF ratioGray matterWhite matterAbsolute cerebral blood volumeCBV ratioIntra-arterial therapyIschemic brain tissueQuantitative CT perfusionDynamic CT perfusionIA therapyRecanalization therapyStroke onsetSalvageable penumbraInfarct coreIschemic tissueUninvolved regionsIschemic regionBlood volumeCBF valuesPatientsBrain tissue
2003
Whole-Brain CT Perfusion Measurement of Perfused Cerebral Blood Volume in Acute Ischemic Stroke: Probability Curve for Regional Infarction
Hunter G, Silvennoinen H, Hamberg L, Koroshetz W, Buonanno F, Schwamm L, Rordorf G, Gonzalez R. Whole-Brain CT Perfusion Measurement of Perfused Cerebral Blood Volume in Acute Ischemic Stroke: Probability Curve for Regional Infarction. Radiology 2003, 227: 725-30. PMID: 12728181, DOI: 10.1148/radiol.2273012169.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeCerebral blood volumeIschemic strokeBlood volumeMajor arterial occlusionLikelihood of infarctionLogistic regression analysisPositive predictive valueCT perfusion measurementsAcute strokeCerebral infarctionArterial occlusionIntracranial hemorrhagePerfusion scanCore infarctionPCBVInfarctionPositive followProbability of survivalRegional infarctionPredictive valuePatientsStrokePerfusion measurementsRegression analysis
2001
CT Perfusion Imaging versus MR Diffusion Weighted Imaging: Prediction of Final Infarct Size in Hyperacute Stroke
Berzin T, Lev M, Goodman D, Koroshetz W, Hunter G, Hamberg L, Buonanno F, Putman C, Budzik R, Eskey C, Schwamm L, Gonzalez R. CT Perfusion Imaging versus MR Diffusion Weighted Imaging: Prediction of Final Infarct Size in Hyperacute Stroke. Stroke 2001, 32: 317-317. DOI: 10.1161/str.32.suppl_1.317.Peer-Reviewed Original ResearchFinal infarct sizeCT perfusion imagingInfarct sizeStroke onsetHyperacute strokeDWI volumePerfusion imagingFinal infarct volumeBrain CT scanningHyperacute stroke patientsSame patient populationMR-Diffusion Weighted ImagingSteady-state administrationCT angiographic imagesDiffusion-Weighted ImagingDWI imagingInfarct volumeConsecutive patientsIndependent predictorsIschemic volumeStroke patientsPatient populationCTP imagingBlood volumePatientsHeterogeneous spatial-temporal evolution of DWI/PWI in human cerebral ischemia
Wu O, Schwamm L, Koroshetz W, Gonzalez R, Pan V, Benner T, Copen W, Ostergaard L, Sorensen A. Heterogeneous spatial-temporal evolution of DWI/PWI in human cerebral ischemia. Stroke 2001, 32: 348-348. DOI: 10.1161/str.32.suppl_1.348-d.Peer-Reviewed Original ResearchCerebral blood flowHuman cerebral ischemiaDWI/PWICerebral blood volumeMean transit timeApparent diffusion coefficientFractional anisotropyCerebral ischemiaRim tissueHuman ischemic strokeElevated fractional anisotropyTwo-sample t-testDWI abnormalitiesInitial DWIIschemic strokeMCA territoryAcute stageIschemic coreSalvageable tissueIntralesional heterogeneityIschemic tissueBlood flowBlood volumeRisk tissuePatients
1999
Hyperacute Stroke: Simultaneous Measurement of Relative Cerebral Blood Volume, Relative Cerebral Blood Flow, and Mean Tissue Transit Time
Sorensen A, Copen W, Ostergaard L, Buonanno F, Gonzalez R, Rordorf G, Rosen B, Schwamm L, Weisskoff R, Koroshetz W. Hyperacute Stroke: Simultaneous Measurement of Relative Cerebral Blood Volume, Relative Cerebral Blood Flow, and Mean Tissue Transit Time. Radiology 1999, 210: 519-27. PMID: 10207439, DOI: 10.1148/radiology.210.2.r99fe06519.Peer-Reviewed Original ResearchConceptsRelative cerebral blood flowCerebral blood flowRelative cerebral blood volumeCerebral blood volumeBlood flowBlood volumeTissue transit timeLesion volumeMR imagingDiffusion findingsAcute lesion volumesCompensatory hemodynamic responseHemodynamic MR imagingCerebral ischemic strokeOnset of symptomsInitial blood flowAltered blood flowBlood volume mapsFunctional magnetic resonance imagingMagnetic resonance imagingTransit time mapsBlood flow mapsInitial blood volumeInfarct volumeHemodynamic abnormalities
1998
Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results.
Hunter G, Hamberg L, Ponzo J, Huang-Hellinger F, Morris P, Rabinov J, Farkas J, Lev M, Schaefer P, Ogilvy C, Schwamm L, Buonanno F, Koroshetz W, Wolf G, González R. Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results. American Journal Of Neuroradiology 1998, 19: 29-37. PMID: 9432154, PMCID: PMC8337333.Peer-Reviewed Original ResearchConceptsHyperacute strokeFunctional CTIschemic changesEarly clinical resultsCerebral blood volumeContrast-enhanced scansHelical CT techniqueOcclusion of vesselsHyperacute groupCerebral perfusionPBV mapsArterial anatomyPatient populationBrain stemClinical resultsCT angiogramContrast administrationRegional perfusionCT angiographyBlood volumePatientsPBV valuesWhite matterGray matterClinical feasibility