2015
Human Adult Retinal Pigment Epithelial Stem Cell–Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native TissuePhysiology of Cultured Adult Human RPE
Blenkinsop TA, Saini JS, Maminishkis A, Bharti K, Wan Q, Banzon T, Lotfi M, Davis J, Singh D, Rizzolo LJ, Miller S, Temple S, Stern JH. Human Adult Retinal Pigment Epithelial Stem Cell–Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native TissuePhysiology of Cultured Adult Human RPE. Investigative Ophthalmology & Visual Science 2015, 56: 7085-7099. PMID: 26540654, PMCID: PMC4640474, DOI: 10.1167/iovs.14-16246.Peer-Reviewed Original Research
2001
Defects in the MITFmi / miApical Surface are Associated with a Failure of Outer Segment Elongation
Bumsted K, Rizzolo L, Barnstable C. Defects in the MITFmi / miApical Surface are Associated with a Failure of Outer Segment Elongation. Experimental Eye Research 2001, 73: 383-392. PMID: 11520113, DOI: 10.1006/exer.2001.1048.Peer-Reviewed Original Research
1997
Remodeling of junctional complexes during the development of the outer blood‐retinal barrier
Williams C, Rizzolo L. Remodeling of junctional complexes during the development of the outer blood‐retinal barrier. The Anatomical Record 1997, 249: 380-388. PMID: 9372172, DOI: 10.1002/(sici)1097-0185(199711)249:3<380::aid-ar9>3.0.co;2-y.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumApical junctional complexOuter blood-retinal barrierBlood-retinal barrierNeural retinaZO-1Junctional complexesOccludin expressionRPE developmentMature retinal pigment epitheliumRPE/choroidZO-1 expressionTight junction proteinsEmbryonic day 3Same molecular massEmbryonic day 10Adherens junctionsPigment epitheliumDay 3Day 10Homologous complexesMolecular massRetinaJunction proteinsJunction permeability
1993
Apical Orientation of the Microtubule Organizing Center and Associated γ-Tubulin during the Polarization of the Retinal Pigment Epithelium in Vivo
Rizzolo L, Joshi H. Apical Orientation of the Microtubule Organizing Center and Associated γ-Tubulin during the Polarization of the Retinal Pigment Epithelium in Vivo. Developmental Biology 1993, 157: 147-156. PMID: 8482407, DOI: 10.1006/dbio.1993.1119.Peer-Reviewed Original ResearchConceptsMicrotubule arraysCell polarityEmbryonic day 3Apical membraneGamma-tubulin fociJunctional complexesSimple epithelial cellsMicrotubule organizing centerDevelopment of epitheliaCentrosomal proteinsJuxtanuclear regionΓ-tubulinUnique reorganizationBasal axisGamma-tubulinCell-basement membrane interactionsFunctional polarityMicrotubule growthMembrane interactionsOrganizing centerPrimary cell culturesCultured cellsEpithelial cellsRetinal pigment epitheliumCell cultures
1991
Basement membrane stimulates the polarized distribution of integrins but not the Na,K-ATPase in the retinal pigment epithelium.
Rizzolo L. Basement membrane stimulates the polarized distribution of integrins but not the Na,K-ATPase in the retinal pigment epithelium. Molecular Biology Of The Cell 1991, 2: 939-949. PMID: 1667092, PMCID: PMC361892, DOI: 10.1091/mbc.2.11.939.Peer-Reviewed Original Research
1990
The distribution of Na+,K+-ATPase in the retinal pigmented epithelium from chicken embryo is polarized in vivo but not in primary cell culture
Rizzolo L. The distribution of Na+,K+-ATPase in the retinal pigmented epithelium from chicken embryo is polarized in vivo but not in primary cell culture. Experimental Eye Research 1990, 51: 435-446. PMID: 2170160, DOI: 10.1016/0014-4835(90)90156-o.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneCells, CulturedChick EmbryoIntercellular JunctionsMicroscopy, ElectronPigment Epithelium of EyeSodium-Potassium-Exchanging ATPaseConceptsBasolateral plasma membranePlasma membranePrimary cell culturesPlasma membrane proteinsFunctional tight junctionsCultured RPEChicken embryosMatrix-coated filtersExtracellular matrix coatingCell culturesMembrane proteinsVesicular stomatitis virusMorphological polarityApical poleCultured cellsApical membraneEngelbreth-HolmJunctional complexesSwarm tumorEmbryonic eyeStomatitis virusATPaseBasolateral membraneSerum-free mediumTight junctions