2020
Evaluating the Clinical Impact of Rapid Response Electroencephalography: The DECIDE Multicenter Prospective Observational Clinical Study.
Vespa PM, Olson DM, John S, Hobbs KS, Gururangan K, Nie K, Desai MJ, Markert M, Parvizi J, Bleck TP, Hirsch LJ, Westover MB. Evaluating the Clinical Impact of Rapid Response Electroencephalography: The DECIDE Multicenter Prospective Observational Clinical Study. Critical Care Medicine 2020, 48: 1249-1257. PMID: 32618687, PMCID: PMC7735649, DOI: 10.1097/ccm.0000000000004428.Peer-Reviewed Original ResearchConceptsNonconvulsive seizuresSeizure diagnosisTreatment planProspective observational clinical studyDiagnostic assessmentObservational clinical studyAssessment of patientsCritical care settingSerious adverse effectsTherapeutic decision makingProspective multicenterSecondary outcomesICU patientsPrimary outcomeStatus epilepticusHigh suspicionElectroencephalography assessmentAcademic hospitalBedside assessmentClinical impactClinical studiesObservational studyCare settingsPhysician confidencePatients
2019
Generalized Periodic Discharges With and Without Triphasic Morphology
Fong MWK, Gaspard N, Hirsch LJ. Generalized Periodic Discharges With and Without Triphasic Morphology. Journal Of Clinical Neurophysiology 2019, 36: 173-174. PMID: 30550491, DOI: 10.1097/wnp.0000000000000549.Peer-Reviewed Original Research
2018
Prevalence and predictors of seizure clusters: A prospective observational study of adult patients with epilepsy
Detyniecki K, O'Bryan J, Choezom T, Rak G, Ma C, Zhang S, Bonito J, Hirsch LJ. Prevalence and predictors of seizure clusters: A prospective observational study of adult patients with epilepsy. Epilepsy & Behavior 2018, 88: 349-356. PMID: 30344026, DOI: 10.1016/j.yebeh.2018.09.035.Peer-Reviewed Original ResearchConceptsRescue medication useProspective observational studyEmergency department visitsHigh seizure frequencySeizure clustersAdult patientsRescue medicationClinical characteristicsSeizure frequencyActive epilepsyDepartment visitsMedication useObservational studyExact testSeizure-related outcomesFisher's exact testLogistic regression modelsSeizure clusteringAdverse outcomesEpilepsy severitySeizure diariesIndividual patientsPatientsEpilepsyFinal analysis
2011
Abbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy(e–Pub ahead of print)
Hirsch LJ, Donner EJ, So EL, Jacobs M, Nashef L, Noebels JL, Buchhalter JR. Abbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy(e–Pub ahead of print). Neurology 2011, 76: 1932-1938. PMID: 21543734, PMCID: PMC3115809, DOI: 10.1212/wnl.0b013e31821de7de.Peer-Reviewed Original ResearchConceptsSudden infant death syndromeSudden unexpected deathSudden cardiac deathCardiac deathUnexpected deathAwareness of SUDEPPrevention of SUDEPRisk of SUDEPImproved seizure controlInfant death syndromeUnderstanding of SUDEPHealth care practitionersBasic science researchSUDEP incidenceDevastating complicationSeizure controlMulticenter collaborative researchSUDEPDeath syndromeAnimal modelsCare practitionersNeurological disordersEpilepsyPhysiologic featuresGenetic factors
2009
Report of the American Epilepsy Society and the Epilepsy Foundation Joint Task Force on Sudden Unexplained Death in Epilepsy
So EL, Bainbridge J, Buchhalter JR, Donalty J, Donner EJ, Finucane A, Graves NM, Hirsch LJ, Montouris GD, Temkin NR, Wiebe S, Sierzant TL. Report of the American Epilepsy Society and the Epilepsy Foundation Joint Task Force on Sudden Unexplained Death in Epilepsy. Epilepsia 2009, 50: 917-922. PMID: 19054406, DOI: 10.1111/j.1528-1167.2008.01906.x.Peer-Reviewed Original ResearchConceptsSudden unexplained deathAmerican Epilepsy SocietyRisk factorsUnexplained deathEpilepsy SocietyRisk of SUDEPPreventable risk factorsPossible preventive strategiesSurvey of patientsComplete autopsy examinationTask ForceTask Force recommendationsConsortium of centersConvulsive seizuresProspective studyBasic research studiesAutopsy examinationSUDEPSUDEP researchPreventive strategiesPatientsEpilepsy FoundationPosition statementCaregiversMedical examiners
2007
Generalized convulsive status epilepticus after nontraumatic subarachnoid hemorrhage: the nationwide inpatient sample.
Claassen J, Bateman BT, Willey JZ, Inati S, Hirsch LJ, Mayer SA, Sacco RL, Schumacher HC. Generalized convulsive status epilepticus after nontraumatic subarachnoid hemorrhage: the nationwide inpatient sample. Neurosurgery 2007, 61: 60-4; discussion 64-5. PMID: 17621019, DOI: 10.1227/01.neu.0000279724.05898.e7.Peer-Reviewed Original ResearchConceptsNontraumatic subarachnoid hemorrhageConvulsive status epilepticusNationwide Inpatient SampleSubarachnoid hemorrhageRenal diseaseStatus epilepticusInpatient SampleNonfederal United States hospitalsGeneralized convulsive status epilepticusDatabase of admissionsDuration of hospitalizationMultivariate logistic regressionUnited States hospitalsHospital mortalityHospital stayAdult patientsYounger patientsIndependent predictorsPatient mortalityEmergency departmentPatientsLinear regression analysisState HospitalNeurosurgical proceduresLogistic regressionConvulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: frequency, predictors, and impact on outcome in a large administrative dataset
Bateman BT, Claassen J, Willey JZ, Hirsch LJ, Mayer SA, Sacco RL, Schumacher HC. Convulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: frequency, predictors, and impact on outcome in a large administrative dataset. Neurocritical Care 2007, 7: 187-193. PMID: 17503112, DOI: 10.1007/s12028-007-0056-2.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeConvulsive status epilepticusIntracerebral hemorrhageIschemic strokeICH cohortRenal diseaseStatus epilepticusSodium imbalanceAlcohol abuseAIS cohortDiagnosis of AISAppropriate ICD-9-CM codesICD-9-CM codesHigh rateNationwide Inpatient SampleAfrican American raceMultivariate logistic regressionLower ratesResultsThe cohortHemorrhagic transformationDiabetes mellitusHemorrhagic strokeIndependent predictorsSerious complicationsHispanic race
2004
Brain monitoring: the next frontier of ICU monitoring.
Hirsch LJ. Brain monitoring: the next frontier of ICU monitoring. Journal Of Clinical Neurophysiology 2004, 21: 305-6. PMID: 15592004.Peer-Reviewed Original ResearchContinuous EEG Monitoring in the Intensive Care Unit: An Overview
Hirsch LJ. Continuous EEG Monitoring in the Intensive Care Unit: An Overview. Journal Of Clinical Neurophysiology 2004, 21: 332-340. PMID: 15592007, DOI: 10.1097/01.wnp.0000147129.80917.0e.Peer-Reviewed Original ResearchConceptsPeriodic epileptiform dischargesComatose patientsEpileptiform dischargesEEG patternsIntensive care unitLevel of sedationContinuous EEG monitoringMajority of seizuresHospital infarctionNoncomatose patientsRecent neurosurgeryClinical seizuresCNS infectionICU patientsIll patientsNonconvulsive seizuresCare unitWorse outcomesAutonomic changesParoxysmal spellsBrain tumorsPatientsEEG monitoringEEG trendsSeizures