2024
Combined neuromodulation and resection for functional cortex epilepsy: a case series.
Merenzon M, Sivaraju A, Herlopian A, Gerrard J, Quraishi I, Hirsch L, Spencer D, Damisah E. Combined neuromodulation and resection for functional cortex epilepsy: a case series. Journal Of Neurosurgery 2024, 1-9. PMID: 38848588, DOI: 10.3171/2024.3.jns24122.Peer-Reviewed Original ResearchMedically refractory epilepsySeizure onset zoneFunctional cortexSeizure outcomeRefractory epilepsyMonths of follow-up dataMaximal safe resectionMedian follow-upTreated with resectionImprove seizure outcomeFocal neuromodulationFollow-up dataPreservation of functionRetrospective analysis of individualsSafe resectionPartial resectionMedian intervalCase seriesPreoperative assessmentSurgical interventionRNS deviceNeurological deficitsNo significant changesResectionRetrospective analysisSystematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regions
2021
Brief potentially ictal rhythmic discharges and paroxysmal fast activity as scalp electroencephalographic biomarkers of seizure activity and seizure onset zone
Yoo JY, Jetté N, Kwon C, Young J, Marcuse LV, Fields MC, Gaspard N, Hirsch LJ. Brief potentially ictal rhythmic discharges and paroxysmal fast activity as scalp electroencephalographic biomarkers of seizure activity and seizure onset zone. Epilepsia 2021, 62: 742-751. PMID: 33576500, DOI: 10.1111/epi.16822.Peer-Reviewed Original ResearchConceptsParoxysmal fast activitySeizure onset zoneIctal rhythmic dischargesClinical significanceElectrographic seizuresSeizure activityRhythmic dischargesFast activityOnset zoneUncontrolled seizure activityPosterior dominant rhythmSimilar clinical significancePatient demographicsElectroencephalographic biomarkerLocalizing signFocal slowingClinical historySeizure riskEEG backgroundPatientsAdult cohortDominant rhythmSeizuresDistinct entityEEG biomarkers
2019
The connectivity index: an effective metric for grading epileptogenicity.
Yan Q, Gaspard N, Zaveri HP, Blumenfeld H, Hirsch LJ, Spencer DD, Alkawadri R. The connectivity index: an effective metric for grading epileptogenicity. Journal Of Neurosurgery 2019, 133: 971-978. PMID: 31561212, DOI: 10.3171/2019.4.jns195.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationSeizure onset zoneSite of stimulationSOZ contactsIrritative zoneComprehensive Epilepsy CenterControl contactsStimulation current intensityHabitual aurasHabitual seizuresEpilepsy centersSeizure generationBrain sitesFrequency stimulationEpileptic activityElectrical stimulationOnset zonePatientsRecording contactsStimulation sessionsBrain regionsFunctional connectivityStimulationOutcome casesSeizures
2013
7T MR spectroscopic imaging in the localization of surgical epilepsy
Pan JW, Duckrow RB, Gerrard J, Ong C, Hirsch LJ, Resor SR, Zhang Y, Petroff O, Spencer S, Hetherington HP, Spencer DD. 7T MR spectroscopic imaging in the localization of surgical epilepsy. Epilepsia 2013, 54: 1668-1678. PMID: 23895497, PMCID: PMC3938332, DOI: 10.1111/epi.12322.Peer-Reviewed Original ResearchConceptsSevere metabolic abnormalitiesLocalization-related epilepsyMR spectroscopic imagingN-acetyl aspartateComplete resectionMetabolic abnormalitiesBetter outcomesMedial temporal lobe epilepsyResection regionTemporal lobe epilepsyNAA/CrSeizure onset zoneSurgical resectionLobe epilepsySurgical approachSeizure localizationMetabolic dysfunctionInternational LeagueSurgical epilepsyGray matterEpilepsyResectionAbnormalitiesMRSI abnormalitiesOutcome prediction