2018
Prevalence and predictors of seizure clusters: A prospective observational study of adult patients with epilepsy
Detyniecki K, O'Bryan J, Choezom T, Rak G, Ma C, Zhang S, Bonito J, Hirsch LJ. Prevalence and predictors of seizure clusters: A prospective observational study of adult patients with epilepsy. Epilepsy & Behavior 2018, 88: 349-356. PMID: 30344026, DOI: 10.1016/j.yebeh.2018.09.035.Peer-Reviewed Original ResearchConceptsRescue medication useProspective observational studyEmergency department visitsHigh seizure frequencySeizure clustersAdult patientsRescue medicationClinical characteristicsSeizure frequencyActive epilepsyDepartment visitsMedication useObservational studyExact testSeizure-related outcomesFisher's exact testLogistic regression modelsSeizure clusteringAdverse outcomesEpilepsy severitySeizure diariesIndividual patientsPatientsEpilepsyFinal analysis
2015
Cross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug use
Chen B, Detyniecki K, Hirsch LJ, Moeller J, Javed A, Kato K, Legge A, Buchsbaum R, Choi H. Cross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug use. Epilepsy & Behavior 2015, 46: 151-157. PMID: 25935515, DOI: 10.1016/j.yebeh.2015.03.020.Peer-Reviewed Original ResearchConceptsAdverse cognitive effectsMore antiepileptic drugsAntiepileptic drugsAbsence seizure typesSpecific antiepileptic drugsAntiepileptic drug useMultiple antiepileptic drugsCertain antiepileptic drugsCognitive effectsHigh rateAED selectionClinical characteristicsIndependent predictorsSeizure typesSingle centerAED loadIndividual patientsPatientsDrug usePhenytoinIntolerabilityAED mechanismsLamotrigineVPAZNS
2009
Cortical and subcortical networks in human secondarily generalized tonic–clonic seizures
Blumenfeld H, Varghese GI, Purcaro MJ, Motelow JE, Enev M, McNally KA, Levin AR, Hirsch LJ, Tikofsky R, Zubal IG, Paige AL, Spencer SS. Cortical and subcortical networks in human secondarily generalized tonic–clonic seizures. Brain 2009, 132: 999-1012. PMID: 19339252, PMCID: PMC2724910, DOI: 10.1093/brain/awp028.Peer-Reviewed Original ResearchConceptsGeneralized tonic-clonic seizuresTonic-clonic seizuresFocal CBF increasesCBF increaseAssociation cortexImpaired consciousnessBasal gangliaSubcortical structuresCerebral blood flow changesBlood flow changesPartial seizure onsetLateral cerebellar hemispheresSingle photon emissionStatistical parametric mappingSecondary generalizationCBF decreasePartial seizuresCerebral cortexMotor manifestationsUpper brainstemSeizure onsetCerebellar hemisphereIndividual patientsTemporal lobeSeizure phase
2008
Cross-sensitivity of skin rashes with antiepileptic drug use
Hirsch LJ, Arif H, Nahm EA, Buchsbaum R, Resor SR, Bazil CW. Cross-sensitivity of skin rashes with antiepileptic drug use. Neurology 2008, 71: 1527-1534. PMID: 18981374, DOI: 10.1212/01.wnl.0000334295.50403.4c.Peer-Reviewed Original ResearchConceptsRate of rashAntiepileptic drugsValproic acidSpecific antiepileptic drugsAntiepileptic drug useMore antiepileptic drugsCertain antiepileptic drugsAED selectionSkin rashIndividual patientsRashPatientsLamotrigineOxcarbazepineDrug usePhenytoinCarbamazepineLevetiracetamZonisamideGabapentinTiagabineVigabatrinClobazamDrugsMedications