2017
Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks‐Kayal A, Engel J, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W. Commonalities in epileptogenic processes from different acute brain insults: Do they translate? Epilepsia 2017, 59: 37-66. PMID: 29247482, PMCID: PMC5993212, DOI: 10.1111/epi.13965.Peer-Reviewed Original ResearchConceptsAcute brain insultsAnimal modelsPrevention therapyBrain insultsBrain injuryInjury etiologyHuman epilepsyClinical testingCentral nervous system infectionFluid percussion injury modelTemporal lobe epilepsy patientsPost-status epilepticus modelDisease modification strategiesNervous system infectionMolecular targetsBetter patient selectionInflammatory cellular infiltrateLoss of neuronsWeeks of injuryBlood-brain barrierTraumatic brain injuryPreclinical animal modelsGap junction couplingCommon histopathologicEpilepsy prevention
2015
The enigma of the latent period in the development of symptomatic acquired epilepsy — Traditional view versus new concepts
Löscher W, Hirsch LJ, Schmidt D. The enigma of the latent period in the development of symptomatic acquired epilepsy — Traditional view versus new concepts. Epilepsy & Behavior 2015, 52: 78-92. PMID: 26409135, DOI: 10.1016/j.yebeh.2015.08.037.Peer-Reviewed Original ResearchConceptsBrain injuryLatent periodBrain insultsAnimal modelsMajor unmet clinical needPre-epileptic stateProcess of epileptogenesisUnderstanding of epileptogenesisTraumatic brain injuryUnmet clinical needAntiepileptogenic agentsAntiepileptogenic treatmentsSymptomatic epilepsyHuman epilepsyTrial designFunctional alterationsEpileptogenesisEpilepsySubclinical epilepsyClinical needInjuryPatientsRecent dataInsultPeriod