2015
Time course of cardiac inflammation during nitric oxide synthase inhibition in SHR: impact of prior transient ACE inhibition
Biwer L, D'souza K, Abidali A, Tu D, Siniard A, DeBoth M, Huentelman M, Hale T. Time course of cardiac inflammation during nitric oxide synthase inhibition in SHR: impact of prior transient ACE inhibition. Hypertension Research 2015, 39: 8-18. PMID: 26490086, DOI: 10.1038/hr.2015.107.Peer-Reviewed Original ResearchConceptsTransient ACE inhibitionNAME treatmentPulse pressureNOS inhibitionACE inhibitionCardiac remodelingInterleukin-6Nitric oxide synthase inhibitionCytokine/chemokine levelsNitric oxide synthase inhibitorMonocyte chemoattractant protein-1Adult male SHRChemokine release profileOxide synthase inhibitionOxide synthase inhibitorChemoattractant protein-1Arginine methyl esterPathological cardiac remodelingChemokine levelsMale SHRCardiac inflammationArterial pressureBlood pressureHypertensive ratsIL-10
2012
Protection against L‐NAME‐induced reduction in cardiac output persists even after cessation of angiotensin‐converting enzyme inhibitor treatment
Biwer L, Broderick T, Xu H, Carroll C, Hale T. Protection against L‐NAME‐induced reduction in cardiac output persists even after cessation of angiotensin‐converting enzyme inhibitor treatment. Acta Physiologica 2012, 207: 156-165. PMID: 22834875, DOI: 10.1111/j.1748-1716.2012.02474.x.Peer-Reviewed Original ResearchConceptsL-NAMEMyocardial injuryCardiac functionEnalapril treatmentACE inhibitionCardiac outputL ratsL-NAME-induced reductionNitric oxide synthase inhibitorShort-term angiotensinTransient ACE inhibitionEnzyme inhibitor treatmentHeart failure treatmentCessation of treatmentOxide synthase inhibitorArginine methyl esterEosin-stained sectionsArterial pressureHypertensive ratsCardiac changesCardiac dysfunctionWashout periodCoronary flowMyocardial infarctionFailure treatment