Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition
Biwer L, Taddeo E, Kenwood B, Hoehn K, Straub A, Isakson B. Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition. Biochimica Et Biophysica Acta 2016, 1861: 671-679. PMID: 27106139, PMCID: PMC4869716, DOI: 10.1016/j.bbalip.2016.04.014.Peer-Reviewed Original ResearchMeSH KeywordsBiological TransportBradykininCalciumCalcium SignalingCell CommunicationCoculture TechniquesCyclic GMPDiglyceridesEgtazic AcidEndoplasmic ReticulumEndothelial CellsGap JunctionsGene Expression RegulationHumansInositol 1,4,5-TrisphosphateMacrocyclic CompoundsMyocytes, Smooth MuscleNitric Oxide Synthase Type IIIOxazolesPhenylephrinePhosphatidylserinesPhosphorylationPrimary Cell CultureProtein Kinase CProtein Kinase InhibitorsThapsigarginEndoplasmic reticulum‐mediated signalling in cellular microdomains
Biwer L, Isakson B. Endoplasmic reticulum‐mediated signalling in cellular microdomains. Acta Physiologica 2016, 219: 162-175. PMID: 26973141, PMCID: PMC5018912, DOI: 10.1111/apha.12675.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumER-mitochondria junctionsImportant cellular organellesSpecific membrane proteinsSynthesis of proteinsLocalized proteinsER membraneCellular physiologyLipid signalingCellular signalingER architectureMembrane proteinsPhospholipid synthasesCellular stressCellular organellesCellular microdomainsOrganism homeostasisCytoplasmic networkSignalingPhospholipid transferIon channelsLipid synthesisTransfer proteinProteinElement expression