Time course of cardiac inflammation during nitric oxide synthase inhibition in SHR: impact of prior transient ACE inhibition
Biwer L, D'souza K, Abidali A, Tu D, Siniard A, DeBoth M, Huentelman M, Hale T. Time course of cardiac inflammation during nitric oxide synthase inhibition in SHR: impact of prior transient ACE inhibition. Hypertension Research 2015, 39: 8-18. PMID: 26490086, DOI: 10.1038/hr.2015.107.Peer-Reviewed Original ResearchConceptsTransient ACE inhibitionNAME treatmentPulse pressureNOS inhibitionACE inhibitionCardiac remodelingInterleukin-6Nitric oxide synthase inhibitionCytokine/chemokine levelsNitric oxide synthase inhibitorMonocyte chemoattractant protein-1Adult male SHRChemokine release profileOxide synthase inhibitionOxide synthase inhibitorChemoattractant protein-1Arginine methyl esterPathological cardiac remodelingChemokine levelsMale SHRCardiac inflammationArterial pressureBlood pressureHypertensive ratsIL-10Persistent change in cardiac fibroblast physiology after transient ACE inhibition
D'Souza K, Biwer L, Madhavpeddi L, Ramaiah P, Shahid W, Hale T. Persistent change in cardiac fibroblast physiology after transient ACE inhibition. AJP Heart And Circulatory Physiology 2015, 309: h1346-h1353. PMID: 26371174, DOI: 10.1152/ajpheart.00615.2015.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme InhibitorsAnimalsCardiomyopathiesCell ProliferationCells, CulturedChemokine CCL2Collagen Type IDisease Models, AnimalEnalaprilFibroblastsFibrosisGranulocyte-Macrophage Colony-Stimulating FactorHeart VentriclesHypertensionInflammation MediatorsMaleNG-Nitroarginine Methyl EsterNitric Oxide SynthasePhenotypeRats, Inbred SHRTime FactorsConceptsTransient ACE inhibitionACE inhibitionFibroblast physiologyArginine methyl ester treatmentCardiac fibroblastsAngiotensin-converting enzyme inhibitionPersistent changesMethyl ester treatmentChemoattractant protein-1Granulocyte macrophage-colony stimulating factorArginine methyl esterMacrophage-colony stimulating factorMacrophage-recruiting chemokinesCardiac fibroblast phenotypeRole of fibroblastsUntreated SHRHypertensive ratsNOS inhibitionWashout periodACE inhibitorsCardioprotective effectsChemokine releaseMyocardial injuryCardiac fibrosisNOS inhibitor