Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall
Billaud M, Lohman A, Johnstone S, Biwer L, Mutchler S, Isakson B. Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall. Pharmacological Reviews 2014, 66: 513-569. PMID: 24671377, PMCID: PMC3973613, DOI: 10.1124/pr.112.007351.Peer-Reviewed Original ResearchConceptsCellular communicationAccumulation of proteinsMechanism of exocytosisSignaling microdomainProper vascular functionPlasma membraneBlood vessel wallCell typesIon channelsMicrodomainsGap junctionsOxygen speciesPotassium channelsVon Willebrand factorPlethora of meansRegulationSpecific regionsEssential componentVessel wall functionWillebrand factorParacrine releaseImportant roleVessel wallExocytosisEndothelium-derived hyperpolarization