2016
Endoplasmic reticulum‐mediated signalling in cellular microdomains
Biwer L, Isakson B. Endoplasmic reticulum‐mediated signalling in cellular microdomains. Acta Physiologica 2016, 219: 162-175. PMID: 26973141, PMCID: PMC5018912, DOI: 10.1111/apha.12675.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumER-mitochondria junctionsImportant cellular organellesSpecific membrane proteinsSynthesis of proteinsLocalized proteinsER membraneCellular physiologyLipid signalingCellular signalingER architectureMembrane proteinsPhospholipid synthasesCellular stressCellular organellesCellular microdomainsOrganism homeostasisCytoplasmic networkSignalingPhospholipid transferIon channelsLipid synthesisTransfer proteinProteinElement expression
2014
Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall
Billaud M, Lohman A, Johnstone S, Biwer L, Mutchler S, Isakson B. Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall. Pharmacological Reviews 2014, 66: 513-569. PMID: 24671377, PMCID: PMC3973613, DOI: 10.1124/pr.112.007351.Peer-Reviewed Original ResearchConceptsCellular communicationAccumulation of proteinsMechanism of exocytosisSignaling microdomainProper vascular functionPlasma membraneBlood vessel wallCell typesIon channelsMicrodomainsGap junctionsOxygen speciesPotassium channelsVon Willebrand factorPlethora of meansRegulationSpecific regionsEssential componentVessel wall functionWillebrand factorParacrine releaseImportant roleVessel wallExocytosisEndothelium-derived hyperpolarization