2020
Assessment of Patient and Caregiver Attitudes and Approaches to Decision-Making Regarding Bone Marrow Transplant for Sickle Cell Disease
Bakshi N, Katoch D, Sinha C, Ross D, Quarmyne M, Loewenstein G, Krishnamurti L. Assessment of Patient and Caregiver Attitudes and Approaches to Decision-Making Regarding Bone Marrow Transplant for Sickle Cell Disease. JAMA Network Open 2020, 3: e206742. PMID: 32469414, PMCID: PMC7260617, DOI: 10.1001/jamanetworkopen.2020.6742.Peer-Reviewed Original ResearchConceptsBone marrow transplantCaregivers of patientsSickle cell diseasePatient decision aidMarrow transplantMedian ageCurative treatmentCell diseaseGroup 2Group 1Caregiver attitudesNovel disease-modifying therapiesDisease-modifying therapiesSickle cell clinicAssessment of patientsFuture prospective studiesRandomized clinical trialsParent trialProspective studyTreatment optionsClinical trialsNeeds assessment phaseMAIN OUTCOMECell clinicPatients
2018
Presence of pain on three or more days of the week is associated with worse patient reported outcomes in adults with sickle cell disease
Bakshi N, Ross D, Krishnamurti L. Presence of pain on three or more days of the week is associated with worse patient reported outcomes in adults with sickle cell disease. Journal Of Pain Research 2018, 11: 313-318. PMID: 29445298, PMCID: PMC5810514, DOI: 10.2147/jpr.s150065.Peer-Reviewed Original ResearchPresence of painSickle cell diseaseChronic SCD painPatient-reported outcomesPain interferenceSCD painMore daysPROMIS scoresChronic painUnadjusted analysesCell diseaseAddiction Clinical Trial Translations Innovations OpportunitiesWorse pain interferenceCore diagnostic criteriaShort-form instrumentEpisodic painPain scoresChronic migraineMajority of daysImpaired qualityProspective studyPhysical functionWorse patientPhysical functioningClinical definitionQuantitative sensory testing is feasible and is well-tolerated in patients with sickle cell disease following a vaso-occlusive episode
Bakshi N, Lukombo I, Belfer I, Krishnamurti L. Quantitative sensory testing is feasible and is well-tolerated in patients with sickle cell disease following a vaso-occlusive episode. Journal Of Pain Research 2018, 11: 435-443. PMID: 29503580, PMCID: PMC5827673, DOI: 10.2147/jpr.s150066.Peer-Reviewed Original ResearchVaso-occlusive episodesQuantitative sensory testingSickle cell diseaseChronic painPain sensitivityCell diseaseSensory testingPainful vaso-occlusive episodesExperience chronic painFeasibility of recruitmentLarge prospective studiesEmergency room visitsExperimental pain sensitivityInherited blood disorderAltered painMedian agePain intensityPediatric patientsRoom visitsProspective studyInpatient hospitalizationSubset of individualsPainPatientsBlood disorders
2010
Prolonged QTc Interval Is Common In Patients with Sickle Cell Disease and Has An Inverse Relationship to Hemoglobin and Hematocrit: Results From CSSCD
Goel R, Rajderkar S, Padman R, Krishnamurti L. Prolonged QTc Interval Is Common In Patients with Sickle Cell Disease and Has An Inverse Relationship to Hemoglobin and Hematocrit: Results From CSSCD. Blood 2010, 116: 2675. DOI: 10.1182/blood.v116.21.2675.2675.Peer-Reviewed Original ResearchSickle cell diseaseProlonged QTcCardiac deathSCD patientsCell diseaseProlonged QTc intervalPremature cardiac deathSudden cardiac deathMultivariate logistic regressionYears of ageLead EKGEchocardiographic characteristicsHbSS patientsClinical courseQTc intervalProspective studyClinical centersHigh riskPatientsQTcStudy subjectsEstablished markerCooperative StudyLogistic regressionNational Institute