2022
Decision-making about gene therapy in transfusion dependent thalassemia
Quarmyne M, Ross D, Sinha C, Bakshi N, Boudreaux J, Krishnamurti L. Decision-making about gene therapy in transfusion dependent thalassemia. BMC Pediatrics 2022, 22: 536. PMID: 36085025, PMCID: PMC9461218, DOI: 10.1186/s12887-022-03598-3.Peer-Reviewed Original ResearchConceptsTransfusion-dependent thalassemiaPatient/family knowledgeDependent thalassemiaTransfusion independenceTreatment optionsStudy participantsGene therapyFamily knowledgeElimination of transfusionsFrequency of transfusionMorbidity/mortalityStem cell transplantationLong-term outcomesPreferred treatment modalityPromising treatment optionBackgroundHematopoietic stem cell transplantationPatients/familiesMethodsParents of childrenCurative intentTransfusion reductionHost diseaseDonor HSCTParents of childrenCell transplantationMean age
2020
Risk Factors and Cardiovascular Disease (CVD) Related Outcomes in Hospitalized Patients with Hemophilia 10 Year Follow up
Day J, Gupta A, Abro C, Jung K, Krishnamurti L, Takemoto C, Goel R. Risk Factors and Cardiovascular Disease (CVD) Related Outcomes in Hospitalized Patients with Hemophilia 10 Year Follow up. Blood 2020, 136: 30-31. DOI: 10.1182/blood-2020-136486.Peer-Reviewed Original ResearchCVD risk factorsAcute myocardial infarctionAtherosclerotic coronary artery diseaseCVD outcomesCoronary artery diseaseNationwide Inpatient SamplePrevalent risk factorsRisk factorsCardiovascular diseaseHaemophilia populationOrder of frequencyHemophilia AArtery diseaseHeart failureHospitalized patientsHaemophilia patientsMean agePrevalence ratesJohns Hopkins Institutional Review BoardUtilization Project Nationwide Inpatient SampleUnadjusted prevalence ratesCardiovascular risk factorsSignificant riskCrude prevalence rateICD-9 codes
2010
Platelet Transfusions In Patients with Immune Thrombocytopenic Purpura (ITP) – Evaluation of the Current Nationwide Inpatient Hospital Practices.
Tran L, Goel R, Krishnamurti L. Platelet Transfusions In Patients with Immune Thrombocytopenic Purpura (ITP) – Evaluation of the Current Nationwide Inpatient Hospital Practices. Blood 2010, 116: 3809. DOI: 10.1182/blood.v116.21.3809.3809.Peer-Reviewed Original ResearchImmune thrombocytopenic purpuraManagement of ITPMajor bleedsPlatelet transfusionsHospital dischargeMortality rateGastrointestinal bleedITP patientsIntracranial hemorrhageNationwide Inpatient Sample 2007Payer inpatient databasePlatelet transfusion practicesInternational consensus guidelinesImproved mortality ratesStratified probability sampleU.S. community hospitalsThrombocytopenic purpuraPlatelet countTransfusion practiceConsensus guidelinesInpatient DatabaseMean ageSevere hemorrhageCommunity hospitalPediatric discharges